DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1494 and abca1b

DIOPT Version :9

Sequence 1:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster
Sequence 2:	XP_005173137.1	Gene:	abca1b / 100136868	ZFINID:	ZDB-GENE-030131-9826	Length:	2282	Species:	Danio rerio

Alignment Length:	1912	Identity:	388/1912 - (20%)
Similarity:	718/1912 - (37%)	Gaps:	507/1912 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 QIEPMTSVGFEDCEEMRESVIENGLF-AGLCFDGSPFVEDQVFEEDTLESYSNIQPMLNYTILLP 181
            ::||:::.  |.......|:::|..| ||:.|...|            .:.|.:.|.:||.|.:.
Zfish   512 KLEPVSTE--EKLVNESMSLLDNRKFWAGIVFLDIP------------SNSSELPPNVNYKIRMD 562

  Fly   182 SELRMLDGDFRMANWMTLYNDDPNTFVLTRLNQPYEGGFVGYVREGFIRLQKSVSESFL-VLTSH 245
            .:........:...|      ||....     .|:|.  :.|:..||..||..|..|.: .:|..
Zfish   563 IDNVERTNKIKDGYW------DPGPRA-----DPFED--LRYIWGGFSYLQDVVEHSIIRAVTGS 614

  Fly   246 KSLPTIQIRRFPITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNI 310
            |....:.|::.|......|..:..::..||..:.:.:::...:.:..||.||::::::.:..|.:
Zfish   615 KEKTGVYIQQMPYPCYVDDIFLRIMSRSMPLFMTLAWMYSVAIIIKGVVYEKEARLKETMRIMGL 679

  Fly   311 GNLIHFVSWYLKGLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMV 375
            .|.|.:.||::..||..:||:.::..|||:     ..:|..:...::.|.|..:....:....::
Zfish   680 DNGILWFSWFISSLIPLLISAGLLVLLLKM-----GNLLPYSDPGVVFLFLGSFAVVTIMQCFLI 739

  Fly   376 AAFFRNALNAVRVLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIE--------- 431
            :..|..|..|.....|::...|:| ::|.      :....||.:| ..|:|:|:..
Zfish   740 STAFARANLAAACGGIIYFTLYLP-YVLC------VAWQDYVGFA-AKVIASLLSPVAFGFGCEY 796

  Fly   432 FLIERESIVHITW--------EDSGYRLNYDGGHITVTASSWIFMLNALVYCAIGLYVD------ 482
            |.:..|..|.|.|        |:..|.|         |....:...:|.:|..:..|::
Zfish   797 FALFEEQGVGIQWNNLFSSPVEEDDYNL---------TTCLILMYFDAFLYGVMTWYIETVFPGQ 852

  Fly   483 --------------MWRGGDRSGKKM---KKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIY 530
                          .|.|.:.:....   ||.|..|...|:
Zfish   853 YGIPRPWYFPFTKSYWFGENSTNNTAIHGKKSNAGAVCIEE------------------------ 893

  Fly   531 EVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPS 595
              ||:|.:..:.|:.|.|.:....:.|::..:...:|.::|..:||||.||:|.:.||.||..|:
Zfish   894 --EPTHLKLGVYIENLVKVYRHGKKLAVDGLTLGFHEGQITSFLGHNGAGKTTTMSILTGLFPPT 956

  Fly   596 RGTVMISSHNIQTERKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLN 660
            .||..|...:|::|..:....||:...|::|.:..||.:::.|..|:|||... |:..:....|:
Zfish   957 SGTAYIMGKDIRSELSSIRQSLGVCPQHNVLFSMLTVEEHIWFYARLKGLSEE-EVKAEMEQILS 1020

  Fly   661 VLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRT 725
            ...:...:..|...|:......:|:..||||.|.::::|:..:.:|...:..:|:|:.:.::.||
Zfish  1021 DTGLPHKRKSRTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLKYRAGRT 1085

  Fly   726 IILVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKN------------- 777
            |:|.::....|:.:.||:||:|:|:|.|.|:..|||...|.||.||.|| ||
Zfish  1086 ILLSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTLVK-KNTEPSLSSCRNSSS 1149

  Fly   778 ----YKRDE---------------------------------------LFGMMNSYMPNMSIERD 799
                .|:|:                                       :..::..::|...:..|
Zfish  1150 TVSFVKKDDNASESSSDAGLGSDQESEAATAIGTSWPESPVVPVDVTIISRLILKHVPAARMVED 1214

  Fly   800 IGYKVTFVL--ENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLR-------------- 848
            .|:::|:||  |:.....|..|..||::.:..||:.|:.:.||::|||||:
Zfish  1215 QGHEITYVLPYESAKNGAFVELFHDLDDRLADLGISSYGVSDTTLEEIFLKVAEDSGVDTEMLSD 1279

  Fly   849 ------------FGC----------ED-----NDQSGAFQSHENAQVLLEEYYSTLAEANEKG-- 884
                        ||.          ||     |:..|..:|.|.      :|   |:.::.||
Zfish  1280 GTLPVRRQRRHAFGADHQSCLKPLTEDDSFDCNESEGDPESKET------DY---LSGSDGKGSY 1335

  Fly   885 RRTGWKLFFLHGRAVIYKRWIAAHRH------WIVLIFEVLAMALVAVCTFSSIF-IYGK----- 937
            :..||.|......|:::||.:.|.|.      .|||....:.:|||    ||.|. .:||
Zfish  1336 QVKGWSLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAVFVCIALV----FSLIVPPFGKYPSLA 1396

  Fly   938 ----NYELEPLTFNLSQLHTV--------------------------DAFVELFSEEEDVKDMHA 972
                .||.:.:.|:....:.|                          ||...:..||....::..
Zfish  1397 LNPWMYEEQFMFFSEDAPYDVSTHKLLRALFDDPGFGTRCMKGESIPDAPCTMGDEEWSTPEVPE 1461

  Fly   973 YYTELL---YW--YDAHVA------------------------------------TLTKNRHNAY 996
            ...|:|   .|  .|...|                                    .||....:.|
Zfish  1462 SIIEILTTRNWTMNDPSPACECSCNGKKKMLPECPAGAGGLPPPQIKISETETLQNLTGRNISDY 1526

  Fly   997 ALLTQNQ-------------------FTAHVNS-----------------RYIF------GATFD 1019
            .:.|..|                   |:....|                 |.||      |:..|
Zfish  1527 LVKTYAQIIGKSLKNKIWVNEFRYGGFSLGARSTQVLPPAEEIDDAISRVREIFQLGKDSGSAAD 1591

  Fly  1020 QKI---------------VTAWFNNIPLHSAPYALNVVHNAVARHLFDEEATIDVTLAPLPFRTA 1069
            :.:               |..||||...||....|||::|.:.|      |.:.....|..|...
Zfish  1592 RFLKSLSAFINGLDTKNNVKIWFNNKGWHSIGAFLNVMNNGILR------ANLPPGKDPSEFGIT 1650

  Fly  1070 INTFP----------PSSHTFGGCLAFGIC--FVLTFIWPAFAIYMITERGSLLKKQQFLAGVRV 1122
            ....|          .:..|....:...||  |.::|:..:|.:::|.||.:..|..||::||:.
Zfish  1651 AYNHPLNLTKEQLSQVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQFISGVQP 1715

  Fly  1123 CSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVMLYGYISVT--------LMLGGFWVILLA 1179
            ..||....|:|:...::....|:::...::..       .|:|.|        |:|.|:.:..|.
Zfish  1716 YLYWLANFLWDMCNYVVPATLVILIFVCFQQK-------AYVSATNLPVLALLLLLYGWSITPLM 1773

  Fly  1180 YLMASLCRNPCYGFLWLCGIN-SIGLVCFSQFYRTHPESMLLEPTFMAMYTVATVICKLFMIYE- 1242
            |..:.|.:.|...::.|..:| .||:                      ..:::|.:.:||..:|
Zfish  1774 YPASFLFKIPSTAYVVLTSVNILIGI----------------------NGSISTFVMELFGNHEI 1816

  Fly  1243 -------------FKLICMDPVVNFTSVEVFKCNSIPNCCIKSNYGTFTAGIYHDLV-------- 1286
                         |...|:...:    :::.|..::.:...:.....|.:.:..|:|
Zfish  1817 GGINDILKNVLLIFPHFCLGRGL----IDMVKNQAMADALERFGENRFRSPLEWDMVGKNLFAMA 1877

  Fly  1287 ---ILTLLDIILLACLFVSEYHSILGFADC-RLDTRTNESPD-SNQESRAFPGILSNDTAALVDK 1346
               ::..:..:|:...|..|..|:     | :|.....|..| :.:..|...|....|...|  :
Zfish  1878 VEGVVFFIITVLIQYRFFFEPKSL-----CPKLSPIGEEDEDVARERQRIMSGAGQGDILEL--R 1935

  Fly  1347 EHTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGANNSGKTTLLKVVVNET 1411
            :.|.....:::.....:.:||                 ...||..:.|.|.:|||:..|::..::
Zfish  1936 QLTKVYKRKQKPAVDRLCVGI-----------------PPGECFGLLGVNGAGKTSTFKMLTGDS 1983

  Fly  1412 KMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAMLQGHRHRIGRELSEAL 1476
            .:..|:.:|...|:.....:.::.:|||||.|::....|.||.|..:|:|:|........::|..
Zfish  1984 VVTKGEAFIAGKSILREIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPENEVCAVAEWG 2048

  Fly  1477 LRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGVPAGLDPTGKRIILMMTSTMQAM 1541
            :|.:||....:::....:.|.:|:|..|.:::|:|.::.:|....|:||..:|.:.....::...
Zfish  2049 IRKLGLVKYVDKNAGSYSGGNMRKLSTAISLIGAPPVVFLDEPTTGMDPKARRALWNCIHSVIKE 2113

  Fly  1542 GSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYKSGYQLEVRFKRKVNPNVSMSRA 1606
            |.|.:.|..:..:.|.|..|..:::.|:...:..:......:..||.:.:|.   ..|:..
Zfish  2114 GRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIILRV---AGPDPD---- 2171

  Fly  1607 TWNLINHFPMSPNKKFSAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIE 1671
                     :.|..|   |:|.:.|.:.|..:..:.:.:.||...|:.:.||..|.|:...:.||
Zfish  2172 ---------LQPVMK---FIESELPGSTLKEKHRNMLQYQLPSSLTSLAHIFSILAKNKEFLRIE 2224

  Fly  1672 DYFITRNML----VGFQIFTYDQHQDN 1694
            ||.:::..|    |.|.....|.|.|:
Zfish  2225 DYSVSQTTLDQVFVNFAKDQSDDHSDS 2251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	46/233 (20%)
		CcmA	541..848	CDD:224054	96/364 (26%)
		ABC_subfamily_A	541..761	CDD:213230	63/219 (29%)
		ABC2_membrane_3	911..>1189	CDD:289468	80/431 (19%)
		ABC2_membrane	<1080..>1188	CDD:304374	27/117 (23%)
		ABC_subfamily_A	1370..1577	CDD:213230	46/206 (22%)
		PRK14255	1371..1586	CDD:172743	46/214 (21%)
abca1b	XP_005173137.1	rim_protein	1..2242	CDD:130324	385/1901 (20%)
		ABC_subfamily_A	902..1121	CDD:213230	63/219 (29%)
		ABC_subfamily_A	1932..2152	CDD:213230	50/238 (21%)
		DUF4162	2146..2238	CDD:290451	22/110 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820