DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA6 and Hsc70-2

DIOPT Version :9

Sequence 1:	NP_002146.2	Gene:	HSPA6 / 3310	HGNCID:	5239	Length:	643	Species:	Homo sapiens
Sequence 2:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	446/637 - (70%)
Similarity:	529/637 - (83%)	Gaps:	11/637 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     8 AVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDA 72
            |:|||||||||||||:|..:|||:|||||||||||||||.:||||:||.||:|.|:|..||||||
  Fly     6 AIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70

Human    73 KRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYL 137
            ||||||||.|..:|.|:|.|||:|::|.||||:.|.::||.|.|.|||||||||:||:|.||.||
  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135

Human   138 GQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDL 202
            |..||.||:||||||||||||||||||:|||||||||||||||||:|||||:...||||||||||
  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 200

Human   203 GGGTFDVSVLSIDAG-VFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLR 266
            |||||||||||||.| :|||||||||||||||||||||||||.|||:|||..|:.||.|||||||
  Fly   201 GGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLR 265

Human   267 TACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKA 331
            ||||||||||||||:|:||||:|.||:|||:.|:|||||||..||||||::|||:||.|||:||.
  Fly   266 TACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKK 330

Human   332 QIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLL 396
            .|||||||||||||||:||||||.|.||:||.|||||||||||||||||:|.|....::|||||:
  Fly   331 AIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLV 395

Human   397 DVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRF 461
            ||||||||:||||||||.|::|||.||.||.|.||||||||..|.||||||||||||||||||.|
  Fly   396 DVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGTF 460

Human   462 ELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAEQ 526
            .|:||||||||||||||.||::|:|||:|.|.|.||||:.||||:||||||||.|::||:.|||:
  Fly   461 NLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAEK 525

Human   527 YKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEK 591
            ||.||:.||:||.:||:|||:::..:.:: :::....:.|.:|.|::|||....:||:.|.||||
  Fly   526 YKVEDDRQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKNSLAEK 589

Human   592 EEYEHQKRELEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPSTGPIIEEVD 643
            ||:|...:|.::||.||.|:::||.  .|.||.|       ..:.|.:||||
  Fly   590 EEFESHLKECQRICTPIMSKIHGGK--KGKSSMG-------KGSHPTVEEVD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	3..388		296/380 (78%)
		HSP70	8..643	CDD:331774	444/635 (70%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	396..511		88/114 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..643		7/26 (27%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	444/635 (70%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	294/375 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730