Protein Alignment XIAP and Bruce

DIOPT Version :10

• Sequence 1: NP_001158.2
• Gene: XIAP / 331
• HGNCID: 592
• Length: 497
• Species: Homo sapiens
• Sequence 2: NP_001262460.1
• Gene: Bruce / 41260
• FlyBaseID: FBgn0266717
• Length: 4976
• Species: Drosophila melanogaster
• Alignment Length: 172
• Identity: 51/172 - (29%)
• Similarity: 66/172 - (38%)
• Gaps: 46/172 - (26%)

Human   160 MYSEEARLKSFQNWP--DYAHLTPRELASAGLYY--TGIG-DQVQCFCCGGKLKNWEPCDRAWSE 219
            |:||..|.::|:.||  ||....|.::|.||.|:  :..| |:..||.|...|..||..|..|||
  Fly   245 MHSEAVRRQTFEKWPHMDYKWALPDQMAQAGFYHQPSSSGEDRAMCFTCSVCLVCWEKTDEPWSE 309

Human   220 HRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQL 284
            |.||.|.|.||.|            ...:|.|.|.....||::                    ..
  Fly   310 HERHSPLCPFVKG------------EYTQNVPLSITYATNPAL--------------------PA 342

Human   285 ARAGFYALGEGD--KVKCFHCG--GGLTDWKPSEDPWEQHAK 322
            ...||..:...|  .|.|..|.  |.|:.|.     .|:|.|
  Fly   343 PGLGFDIISNSDYANVLCTSCSQTGELSVWS-----IERHLK 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XIAP	NP_001158.2	BIR 1	26..93
		BIR	28..95	CDD:237989
		Interaction with caspase-7	141..149
		BIR	162..232	CDD:197595	32/74 (43%)
		BIR 2	163..230		29/71 (41%)
		Required for interaction with SEPTIN4 isoform ARTS. /evidence=ECO:0000269|PubMed:21695558	262..277		0/14 (0%)
		BIR	265..331	CDD:197595	12/62 (19%)
		BIR 3	265..330		12/62 (19%)
		Required for interaction with DIABLO. /evidence=ECO:0000269|PubMed:21695558	329..350
		UBA_BIRC4_8	370..419	CDD:270578
		RING-HC_BIRC4_8	434..497	CDD:438374
		Required for ubiquitination and subsequent degradation of BCL2 during apoptosis. /evidence=ECO:0000269|PubMed:29020630	450..497
Bruce	NP_001262460.1	BIR	251..321	CDD:459891	29/69 (42%)
		BIRC6	3539..3664	CDD:463547
		UBCc_BIRC6	4631..4835	CDD:467430