DRSC/TRiP Functional Genomics Resources

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Protein Alignment XIAP and Diap1

DIOPT Version :10

Sequence 1:NP_001158.2 Gene:XIAP / 331 HGNCID:592 Length:497 Species:Homo sapiens
Sequence 2:NP_524101.2 Gene:Diap1 / 39753 FlyBaseID:FBgn0260635 Length:438 Species:Drosophila melanogaster


Alignment Length:495 Identity:131/495 - (26%)
Similarity:184/495 - (37%) Gaps:182/495 - (36%)


- Green bases have known domain annotations that are detailed below.


Human   121 LGSRDHFALDR-PSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWP-DYAHLTPRE 183
            |.|....|.|: .:.|:|..|.:.    :|:.|   |...:..||.|||:|.:|| |:  |..|:
  Fly     8 LPSYGPIAFDQVDNNTNATQLFKN----NINKT---RMNDLNREETRLKTFTDWPLDW--LDKRQ 63

Human   184 LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDR 248
            ||..|:|:|..||:|:||.||.::..||..|:...||:|..|||..:..|..| ....:|.:.||
  Fly    64 LAQTGMYFTHAGDKVKCFFCGVEIGCWEQEDQPVPEHQRWSPNCPLLRRRTTN-NVPINAEALDR 127

Human   249 NFP-------------------------------------NSTN--------------------- 255
            ..|                                     |:.|                     
  Fly   128 ILPPISYDICGANDSTLEMREHAYAEGVIPMSQLIQSIGMNAVNAAGSVTGTAAPQPRVTVATHA 192

Human   256 ------------------------LPRNPSMADYEARIFTFGTWIYSVNKE--QLARAGFYALGE 294
                                    .|:.|..|...||:.||..|..::.::  |||.|||:..|.
  Fly   193 STATQATGDVQPETCRPSAASGNYFPQYPEYAIETARLRTFEAWPRNLKQKPHQLAEAGFFYTGV 257

Human   295 GDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKT 359
            ||:|:||.|||||.||..:::||||||.|...|:::...|||.||                    
  Fly   258 GDRVRCFSCGGGLMDWNDNDEPWEQHALWLSQCRFVKLMKGQLYI-------------------- 302

Human   360 PSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQD 424
                    ||:...|::.|.             .||...|.|       |.||      .....:
  Fly   303 --------DTVAAKPVLAEE-------------KEESSSIGG-------VAVA------STQASE 333

Human   425 ESSQTSLQKEISTEEQL--------------------------------RRLQEEKLCKICMDRN 457
            |..||||..|.:....:                                ..:.||||||||....
  Fly   334 EEQQTSLSSEEAVSGDVAPSVAPTAATRIFNKIVEATAVATPSTNSSGSTSIPEEKLCKICYGAE 398

Human   458 IAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 497
            ....|:||||:|.|.:||.:|.|||:|....|...:::.|
  Fly   399 YNTAFLPCGHVVACAKCASSVTKCPLCRKPFTDVMRVYFS 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XIAPNP_001158.2 BIR 1 26..93
BIR 28..95 CDD:237989
Interaction with caspase-7 141..149 0/7 (0%)
BIR 162..232 CDD:197595 32/70 (46%)
BIR 2 163..230 32/67 (48%)
Required for interaction with SEPTIN4 isoform ARTS. /evidence=ECO:0000269|PubMed:21695558 262..277 6/14 (43%)
BIR 265..331 CDD:197595 32/67 (48%)
BIR 3 265..330 32/66 (48%)
Required for interaction with DIABLO. /evidence=ECO:0000269|PubMed:21695558 329..350 5/20 (25%)
UBA_BIRC4_8 370..419 CDD:270578 9/48 (19%)
RING-HC_BIRC4_8 434..497 CDD:438374 24/94 (26%)
Required for ubiquitination and subsequent degradation of BCL2 during apoptosis. /evidence=ECO:0000269|PubMed:29020630 450..497 19/46 (41%)
Diap1NP_524101.2 BIR 44..112 CDD:197595 32/69 (46%)
BIR 226..295 CDD:197595 32/68 (47%)
RING-HC_IAPs 388..427 CDD:438173 21/38 (55%)
Blue background indicates that the domain is not in the aligned region.

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