Protein Alignment XIAP and Diap2

DIOPT Version :10

• Sequence 1: NP_001158.2
• Gene: XIAP / 331
• HGNCID: 592
• Length: 497
• Species: Homo sapiens
• Sequence 2: NP_477127.1
• Gene: Diap2 / 36748
• FlyBaseID: FBgn0015247
• Length: 498
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 161/548 - (29%)
• Similarity: 241/548 - (43%)
• Gaps: 118/548 - (21%)

Human    16 DINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAV 80
            ::..|.|.|    ||.||..:|..:||||..|...||..||......|..||..:|||:|||...
  Fly     3 ELGMELESV----RLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVA 63

Human    81 GRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQ 145
            .|||:.||.|..:                      ...|:.|:     :.|..|:..:    ...
  Fly    64 ERHRRSSPICSMV----------------------LAPNHCGN-----VPRSQESDNE----GNS 97

Human   146 VVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNW 210
            |||..::.  ..|.:..|..||.:|::||: .::||:.||.||.||....|.|:|..|.|.:..|
  Fly    98 VVDSPESC--SCPDLLLEANRLVTFKDWPN-PNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKW 159

Human   211 EPCDRAWSEHRRHFPNC---------FFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYE 266
            |..|.|:.||:|.||.|         .|..|:||           |......|.||..|..|..:
  Fly   160 EKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNL-----------DELGIQPTTLPLRPKYACVD 213

Human   267 ARIFTFGTW-IYSVN-KEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKY 329
            ||:.||..| |.::. ...||:||.|....||:|:||||..||..|:..::||.:||||.|.|::
  Fly   214 ARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQF 278

Human   330 LLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIME 394
            :|..||..|::.:..|.:........|...|:|..   |.:......:||:.:|.....::..::
  Fly   279 VLLAKGPAYVSEVLATTAANASSQPATAPAPTLQA---DVLMDEAPAKEALALGIDGGVVRNAIQ 340

Human   395 EKIQISGSNYKSLEVL-------------------------------------------VADLVN 416
            .|:..||..:.:|:.|                                           |||.:.
  Fly   341 RKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIP 405

Human   417 AQKDSMQDESSQTSLQKEI------------STEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLV 469
            |:..:.:..::.:.:..||            |.||:.|:|::.:|||:|:|..:.:||:|||||.
  Fly   406 AKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLA 470

Human   470 TCKQCAEAVDKCPMCYTVITFKQKIFMS 497
            ||.|||.:|..||||...|....:.|:|
  Fly   471 TCNQCAPSVANCPMCRADIKGFVRTFLS 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
XIAP	NP_001158.2	BIR 1	26..93		29/66 (44%)
		BIR	28..95	CDD:237989	29/66 (44%)
		Interaction with caspase-7	141..149		2/7 (29%)
		BIR	162..232	CDD:197595	30/78 (38%)
		BIR 2	163..230		29/75 (39%)
		Required for interaction with SEPTIN4 isoform ARTS. /evidence=ECO:0000269|PubMed:21695558	262..277		6/15 (40%)
		BIR	265..331	CDD:197595	29/67 (43%)
		BIR 3	265..330		29/66 (44%)
		Required for interaction with DIABLO. /evidence=ECO:0000269|PubMed:21695558	329..350		5/20 (25%)
		UBA_BIRC4_8	370..419	CDD:270578	12/91 (13%)
		RING-HC_BIRC4_8	434..497	CDD:438374	31/74 (42%)
		Required for ubiquitination and subsequent degradation of BCL2 during apoptosis. /evidence=ECO:0000269|PubMed:29020630	450..497		23/46 (50%)
Diap2	NP_477127.1	BIR	12..78	CDD:237989	29/87 (33%)
		BIR	112..181	CDD:197595	29/69 (42%)
		BIR	213..281	CDD:237989	29/67 (43%)
		UBA_IAPs	320..363	CDD:270506	8/42 (19%)
		RING-HC_BIRC2_3_7	442..498	CDD:438373	26/55 (47%)