DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15445 and CG5111

DIOPT Version :9

Sequence 1:	NP_001259756.1	Gene:	CG15445 / 33094	FlyBaseID:	FBgn0031161	Length:	618	Species:	Drosophila melanogaster
Sequence 2:	NP_651402.1	Gene:	CG5111 / 43085	FlyBaseID:	FBgn0039343	Length:	614	Species:	Drosophila melanogaster

Alignment Length:	625	Identity:	291/625 - (46%)
Similarity:	426/625 - (68%)	Gaps:	20/625 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSQNDNLLIQIRALLQSDGEKLWEEPYYSEDLGSIEGALENLAQKYSGMLGIDIGRCKFFLTELQ 65
            |||.:|:.|::||.|:....||||||||.|::||||..::.||:..||.|||.:..|:..|.|||
  Fly     1 MSQINNIFIKLRARLRERDIKLWEEPYYFEEVGSIESEMDRLARDISGELGISVSDCRIALGELQ 65

  Fly    66 ENALRTLAARREFSTTGIATLKVRRVGEHSGAT-MVEVKCSLDIVGSELQACIAKKLEVPNAAHV 129
            :.|||.|||||||:.||:||..||.|....|.. |:|:||||..:||:|||.:||||::.:::||
  Fly    66 DGALRKLAARREFNDTGLATFNVRCVDSKGGTVQMLEIKCSLGGLGSDLQAEVAKKLDIVDSSHV 130

  Fly   130 KCIAAGKVVSANATLADQQLKNNQQLIVIVGDGDNSGEALYERINRIKADVEAVVSSKNNLIEME 194
            |||:.|::::...|||.|.||.||.|:|:|| |.|.|:.|:|||.||:||:| :|:..:..:|||
  Fly   131 KCISGGRIINGQKTLASQGLKTNQHLMVVVG-GTNEGQELHERIQRIRADLE-LVADADRFMEME 193

  Fly   195 DQNGSQVYLPPSEHKALLMGLGFCEKARAAMNRKHFEEALLLLLEADEHFSTCGSKFLESVDNYA 259
            ||:|..::||..|:::|||.:...|.||.||::::|:||||:||||||.||.|.||.||.|||||
  Fly   194 DQDGRPIFLPREENRSLLMAMSMYEVARVAMHKENFDEALLILLEADELFSQCDSKLLEGVDNYA 258

  Fly   260 LLNLDIVWCYFCLKNVTQLPDAEHRLARCSRNFGISYGDNLERLYSLKGKDCPERALIMRLKLLQ 324
            |:||||||||..|||:||||||:.||..|.|.|..|||:...||:|:||...|||||||||.|||
  Fly   259 LINLDIVWCYLRLKNITQLPDAQRRLDICERGFVKSYGEQFIRLFSIKGPSSPERALIMRLHLLQ 323

  Fly   325 GVIFFHQNLRNQAFECFEAAKTLLNELKINNDQLALLVDMGFEPSEARMALRSCKGGTAVEQAVQ 389
            ||:.||||.|::|:|..|.|...|.|:|:|:.:|:.||:||:|.|:||:|||||.|  .|::|:|
  Fly   324 GVLLFHQNRRDEAYEKLEVATKDLYEVKMNDTELSTLVEMGYEESDARLALRSCAG--QVDRAIQ 386

  Fly   390 FIHERRQQLKNARMKYKASERAMERRLKRSNSKDCTWVNPRSVCSLADMGFESGLATIALQRSNN 454
            :|.||.:::...| |..|:||.:.:.:..: .:...||||||:..|.:||:|..|...||:|:.|
  Fly   387 YIQERSERISEER-KNSAAERQVNQEMIFA-GQGGEWVNPRSIIRLMEMGYERRLVVEALKRTKN 449

  Fly   455 DILQAVELLQTESDELTGASPWFPVTVDTTKLAQLLQLGFNENDSRVALQNASNNMEEAIESLMC 519
            ::.::::|||..||||....|..| .||.:.|..|..|||:|..:|.||:...|:..::::.|:.
  Fly   450 NLDRSLDLLQRHSDELRANLPPIP-PVDESLLTTLQHLGFSEISARDALETTGNSFHKSLKFLLK 513

  Fly   520 AIESEEELKAILKHVGRLAENGGQNLDGP-STSNASGQTQVAL------PAPIIEAVINHARVEI 577
            :..:|.||..:::.:.::.|     :..| |::||:..:...|      ...:::.|::.|:.||
  Fly   514 SFPNESELLHVIETMTKVLE-----VQEPTSSTNATANSTTPLVNLSNSKVNLLQTVLSEAKSEI 573

  Fly   578 ETYKAYERFNSDLKLSDLEYLDLPLIQEEKILTEYFNMLQ 617
            |:|.|::|||.:|..::..||:|||.|||:||.||..:|:
  Fly   574 ESYNAFKRFNENLAENNNHYLNLPLDQEEQILIEYKRLLE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15445	NP_001259756.1	UBA1_NUB1_like	354..391	CDD:270477	19/36 (53%)
		UBA_like_SF	429..463	CDD:304366	12/33 (36%)
		UBA_like_SF	484..519	CDD:304366	11/34 (32%)
CG5111	NP_651402.1	UBA1_NUB1_like	353..388	CDD:270477	19/36 (53%)
		UBA2_UBP13	424..458	CDD:270570	12/33 (36%)
		UBA	475..511	CDD:279021	12/35 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464463
Domainoid	1	1.000	128	1.000	Domainoid score	I5265
eggNOG	1	0.900	-	-		E1_KOG2561
Homologene	1	1.000	-	-		H41108
Inparanoid	1	1.050	162	1.000	Inparanoid score	I1615
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48673
OrthoDB	1	1.010	-	-		D1339766at2759
OrthoFinder	1	1.000	-	-		FOG0005370
OrthoInspector	1	1.000	-	-		otm25023
orthoMCL	1	0.900	-	-		OOG6_106196
Panther	1	1.100	-	-	P	PTHR12948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5142
SonicParanoid	1	1.000	-	-		X4302
	14	13.840