DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA5 and Hsp70Bb

DIOPT Version :10

Sequence 1:NP_005338.1 Gene:HSPA5 / 3309 HGNCID:5238 Length:654 Species:Homo sapiens
Sequence 2:NP_524927.2 Gene:Hsp70Bb / 48582 FlyBaseID:FBgn0013278 Length:641 Species:Drosophila melanogaster


Alignment Length:640 Identity:384/640 - (60%)
Similarity:491/640 - (76%) Gaps:28/640 - (4%)


- Green bases have known domain annotations that are detailed below.


Human    31 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 95
            :|||||||||||||:::|:|||||||||||.|||||||| :.||||||.||||:..||.||||||
  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67

Human    96 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 160
            ||||||.::||.:.:|:|..|||||....||.|.|:. .|::|.|||||||:|||||||||||||
  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEY-KGESKRFAPEEISSMVLTKMKETAEAY 131

Human   161 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 224
            ||:.:|.||:||||||||:|||||||||.||||||:||||||||||:||||||. :||:|:|:||
  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196

Human   225 LGGGTFDVSLLTIDNG-VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKL 288
            |||||||||:||||.| :|||.:|.|||||||||||.|::.|..:.:|:|..||:|.:.||:::|
  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRL 261

Human   289 RREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKK 353
            |...|:|||.|||..:|.|||::.:||:||...::||:||||..||||:|::||:|.|.|:.:.|
  Fly   262 RTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDK 326

Human   354 SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQD--TGDLVL 416
            ..|.:||||||||||||:|.|::|||:||..:..|||||||||||||||.:|||||.  ..|::|
  Fly   327 GQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLL 391

Human   417 LDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGT 481
            :||.||:|||||.||||||||.||..:|.|:::.|||.|||||.|:|:||||||.:||||:.|||
  Fly   392 VDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGT 456

Human   482 FDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAE 546
            |||:||||||||||||||||::|.||||.|:|::..||....|||.||:.||:..||:||||:||
  Fly   457 FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAE 521

Human   547 KFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDA 611
            |:|:||:|.::||.:||.||||.:::|..:  ::...|||...||.::.....|.|.||:|:..|
  Fly   522 KYADEDEKHRQRITSRNALESYVFNVKQSV--EQAPAGKLDEADKNSVLDKCNETIRWLDSNTTA 584

Human   612 DIEDFKAKKKELEEIVQPIISKLY----GSAGPP----------------PTGEE 646
            :.|:|..|.:||.....||::|::    |:||.|                ||.||
  Fly   585 EKEEFDHKMEELTRHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGYSGPTVEE 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA5NP_005338.1 Required for interaction with ELAPOR1. /evidence=ECO:0000269|PubMed:26045166 1..80 39/48 (81%)
HSP70 30..635 CDD:394970 376/607 (62%)
Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085 125..280 111/156 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 3/11 (27%)
Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085 420..500 58/79 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..654 9/34 (26%)
Prevents secretion from ER. /evidence=ECO:0000255 651..654
Hsp70BbNP_524927.2 PTZ00009 2..641 CDD:240227 384/640 (60%)
Blue background indicates that the domain is not in the aligned region.

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