Protein Alignment HSPA5 and Hsp110

DIOPT Version :10

• Sequence 1: NP_005338.1
• Gene: HSPA5 / 3309
• HGNCID: 5238
• Length: 654
• Species: Homo sapiens
• Sequence 2: NP_001189103.1
• Gene: Hsp110 / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 717
• Identity: 195/717 - (27%)
• Similarity: 342/717 - (47%)
• Gaps: 110/717 - (15%)

Human    29 TVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVF 93
            :|:|||.|.....|...::|.:|.:|||...|.|||:|||..: :|:||.|||||..:|.:|||.
  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGK-KRIIGVAAKNQQVTNMKNTVG 65

Human    94 DAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGG-GQTKTFAPEEISAMVLTKMKETA 157
            ..|||:||.:|||.||.::..:|.: ||.:....|.:.:.. |:.:.|.||:::||:.||:|||:
  Fly    66 GFKRLLGRKFNDPHVQHELTSIPAR-VEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETS 129

Human   158 EAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDK----REGEK 218
            .|.:..:|...|:..|.:|.:|:|:|..||..||||||:|::||.||.|:|||..|    .:..:
  Fly   130 AAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPR 194

Human   219 NILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNR 283
            |::..|.|..:...|......|..:::|:..| .:||.|.|..:.::|.|.::::...:.:.:.|
  Fly   195 NVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNAR 258

Human   284 AVQKLRREVEKAKRALSSQH-QARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLE 347
            |..:|..|:||.|:.:|:.. :..:.||.|.:..|.|.::.|::.|||...:.:...:..:::|.
  Fly   259 ANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLA 323

Human   348 DSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTG 412
            :|.|:..||..:.:||||:|||.::||:::.|| |..|..:|.||||:.|||:|..::|......
  Fly   324 ESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387

Human   413 DLVLLDVCPLTLGI--ETVGGVMTKLIPRNTVVPTKKSQIFS---TASDNQPTVTIKVYEGERPL 472
            :..:.|:....:.:  ::.|......|   .:.|...:..||   |.:...|.....||..:.|.
  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEI---EIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPY 449

Human   473 TKDNHLLGTFDLTGIPPAPRGVPQ-IEVTFEIDVNGILRVT---------------------AED 515
              .:..:|.:.:..:.|..||..| :::...|:.|||:.::                     :|:
  Fly   450 --PDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512

Human   516 K-------------------------------------------------GTGNKNKITITND-- 529
            |                                                 |...|.|.:...:
  Fly   513 KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELP 577

Human   530 ----QNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQI--GDKEKLGGKLSS 588
                .:..:|.::........|....|:|..||||.:|.||.:.|.::|::  |..|:.   :..
  Fly   578 LECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERY---VVE 639

Human   589 EDKETMEKAVEEKIEWL-ESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKD 652
            .::|.:...:.:...|| |..:|.:.:.:.::.:.|.:...||  ||..|     ..|:..|..|
  Fly   640 AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRAS-----DYEQGPAAFD 697

Human   653 EL 654
            ||
  Fly   698 EL 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA5	NP_005338.1	Required for interaction with ELAPOR1. /evidence=ECO:0000269|PubMed:26045166	1..80		21/50 (42%)
		HSP70	30..635	CDD:394970	188/695 (27%)
		Nucleotide-binding (NBD). /evidence=ECO:0000303|PubMed:28286085	125..280		51/159 (32%)
		Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9	409..419		0/9 (0%)
		Substrate-binding (SBD). /evidence=ECO:0000303|PubMed:28286085	420..500		15/85 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..654		6/20 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	651..654		1/2 (50%)
Hsp110	NP_001189103.1	ASKHA_NBD_HSP70_HSPA4_like	4..378	CDD:466826	137/377 (36%)