DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15446 and Snai1

DIOPT Version :9

Sequence 1:NP_608430.2 Gene:CG15446 / 33088 FlyBaseID:FBgn0031155 Length:373 Species:Drosophila melanogaster
Sequence 2:NP_035557.1 Gene:Snai1 / 20613 MGIID:98330 Length:264 Species:Mus musculus


Alignment Length:258 Identity:53/258 - (20%)
Similarity:70/258 - (27%) Gaps:94/258 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 RPPSAATAARMASEFARQVGGISQSPTIEDEGKSGEQSVMQPKSKKANKMPDKVADKLATKSEPK 181
            ||.:.||.....|..|.::..:|.    ||.|||                           |:|.
Mouse    70 RPVAWATLPLRESPKAVELTSLSD----EDSGKS---------------------------SQPP 103

  Fly   182 SEESNVPVKIKVEGVEHNAEGSQSDSMVNTNQGFTTNRNFI--PILSSFPNPYRNMDVTWTEQFN 244
            |..|..|                 .|..:|:........||  |.|...|.....:.|....|..
Mouse   104 SPPSPAP-----------------SSFSSTSASSLEAEAFIAFPGLGQLPKQLARLSVAKDPQSR 151

  Fly   245 ALSN-QYYNHIMNSISSLSQIQPLNSTPSANPPIFGANPMVMGRHPPFSVFSCPLDYCKENFDSR 308
            .:.| :|.|....|:.:|..                        |.......|....|.:.|...
Mouse   152 KIFNCKYCNKEYLSLGALKM------------------------HIRSHTLPCVCTTCGKAFSRP 192

  Fly   309 RAMYKHQR-ETGHHNWPHNCSKCGQVFRTSGFMRMH----------SVNACARN------LHK 354
            ..:..|.| .||..  |.:||.|.:.|.....:|.|          ...||||.      |||
Mouse   193 WLLQGHVRTHTGEK--PFSCSHCNRAFADRSNLRAHLQTHSDVKRYQCQACARTFSRMSLLHK 253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15446NP_608430.2 None
Snai1NP_035557.1 SNAG domain. /evidence=ECO:0000305 1..20
Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250|UniProtKB:O95863 2..7
LATS2 binding. /evidence=ECO:0000250 10..40
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..116 13/78 (17%)
Destruction motif 95..100 4/31 (13%)
Required for FBXL14-triggered degradation. /evidence=ECO:0000250 120..151 7/30 (23%)
Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000250 151..264 27/129 (21%)
C2H2 Zn finger 156..176 CDD:275368 5/43 (12%)
COG5048 <177..>253 CDD:227381 19/77 (25%)
C2H2 Zn finger 182..202 CDD:275368 4/19 (21%)
zf-H2C2_2 195..218 CDD:290200 8/24 (33%)
zf-C2H2 208..230 CDD:278523 6/21 (29%)
C2H2 Zn finger 210..230 CDD:275368 6/19 (32%)
C2H2 Zn finger 238..255 CDD:275368 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2462
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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