DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stt3A and Stt3b

DIOPT Version :9

Sequence 1:	NP_001259751.2	Gene:	Stt3A / 33082	FlyBaseID:	FBgn0031149	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_077184.2	Gene:	Stt3b / 68292	MGIID:	1915542	Length:	823	Species:	Mus musculus

Alignment Length:	726	Identity:	430/726 - (59%)
Similarity:	533/726 - (73%)	Gaps:	25/726 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GVARGLLTWDKQEHLVKLAILILAAVLSFATRLFSVLRFESVIHEFDPYFNYRTTRFLAEQGFYK 71
            |::.||......:.|:...||.||.:..|::|||:|:||||:||||||:||||:|..||..|||:
Mouse    54 GLSGGLSQPAGWQSLLSFTILFLAWLAGFSSRLFAVIRFESIIHEFDPWFNYRSTHHLASHGFYE 118

  Fly    72 FHNWFDDRAWYPLGRIIGGTIYPGLMLTSAALYRLMWLLNVTIDIRNVCVFLAPFFSSLTTLVTY 136
            |.||||:|||||||||:|||:|||||:|:..::.::..||:|:.||:|||||||.||.||::.|:
Mouse   119 FLNWFDERAWYPLGRIVGGTVYPGLMITAGLIHWILNTLNITVHIRDVCVFLAPTFSGLTSISTF 183

  Fly   137 ALTKEIHSTGAGLVAAALISIVPGYISRSVAGSYDNEGIAIFCMLFTYYLWIKAVKTGTIFWSAM 201
            .||:|:.:.||||:||..|:|||||||||||||:||||||||.:.||||||:|:||||::||:..
Mouse   184 LLTRELWNQGAGLLAACFIAIVPGYISRSVAGSFDNEGIAIFALQFTYYLWVKSVKTGSVFWTMC 248

  Fly   202 SALAYFYMVSSWGGYVFLINLIPLHVLALMITGRFSHRIYIAYSTLYCVGTILSMQISFVGFQPI 266
            ..|:||||||:||||||:||||||||..|::..|:|.|:||||||.|.||.||||||.|||||||
Mouse   249 CCLSYFYMVSAWGGYVFIINLIPLHVFVLLLMQRYSKRVYIAYSTFYIVGLILSMQIPFVGFQPI 313

  Fly   267 QSSEHMLALGTFGLCQIHAFVDYLRSRIPKDHFDLLFKTLVSSVLTVVFVVGTLLTLTGKVSPWT 331
            ::||||.|.|.|.|.|.:||:.|||.|:.|..|..||...||.....||:....||.||.::||:
Mouse   314 RTSEHMAAAGVFALLQAYAFLQYLRDRLTKQEFQTLFFLGVSLAAGAVFLSVIYLTYTGYIAPWS 378

  Fly   332 GRFYSLLDPSYAKNHIPIIASVSEHQPTSWSSFYFDLQILVFLFPAGLYFCFSKLTDSNIFIILY 396
            ||||||.|..|||.||||||||||||||:|.||:|||.|||..|||||:||...:.|..:|:.||
Mouse   379 GRFYSLWDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHILVCTFPAGLWFCIKNINDERVFVALY 443

  Fly   397 GVTSIYFAGVMVRLMLVLAPVMCVLSGIAISHLLAKYI----KSVDAGSSSKQGVESKRQHKKLE 457
            .::::|||||||||||.|.||:|:||.||.|::...|:    |..:.........:.||....|.
Mouse   444 AISAVYFAGVMVRLMLTLTPVVCMLSAIAFSNVFEHYLGDDMKRENPPVEDSSDEDDKRNPGNLY 508

  Fly   458 QQTGGV--------KSEVAIG-----FVGVITLMLI-VYTLHCTWVTSEAYSSPSIVLSARSHDG 508
            .:.|.|        |.|..:|     .|.::.|||: ::.:|||||||.||||||:||::.:|||
Mouse   509 DKAGKVRKHVTEQEKPEEGLGPNIKSIVTMLMLMLLMMFAVHCTWVTSNAYSSPSVVLASYNHDG 573

  Fly   509 GRIIFDDFREAYYWLQMNTPEDARIMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASS 573
            .|.|.|||||||:||:.||.|.||:||||||||||..|||||.|||||||||:||:.||:||:|:
Mouse   574 TRNILDDFREAYFWLRQNTDEHARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSN 638

  Fly   574 EEKAYEIMRELDVDYVLVIFGGLTGYSSDDINKFLWMVRIGGSTDRGAH---IREKDYYAANGEF 635
            |..||:|||.||||||||||||:.|||.||||||||||||.    .|.|   |||.||:...|||
Mouse   639 ETAAYKIMRSLDVDYVLVIFGGVIGYSGDDINKFLWMVRIA----EGEHPKDIREGDYFTQQGEF 699

  Fly   636 RVDKEGSPTLLNCLMYKMCYYRFGQMYTEGGKAQGYDRVRAAEIGNKDFELDVMEEAYTTEHWLV 700
            ||||.|||||||||||||.|||||:|..:.....|:||.|.|||||||.:...:|||:|:|||||
Mouse   700 RVDKAGSPTLLNCLMYKMSYYRFGEMQLDFRTPPGFDRTRNAEIGNKDIKFKHLEEAFTSEHWLV 764

  Fly   701 RIYKVKDLPNR 711
            ||||||...||
Mouse   765 RIYKVKAPDNR 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stt3A	NP_001259751.2	Stt3	19..712	CDD:224206	427/714 (60%)
Stt3A	NP_001259751.2	STT3	21..495	CDD:280649	276/491 (56%)
Stt3b	NP_077184.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		1/3 (33%)
		STT3	68..560	CDD:280649	276/491 (56%)
		DXD motif 1. /evidence=ECO:0000250\|UniProtKB:Q5HTX9	98..100		1/1 (100%)
		DXD motif 2. /evidence=ECO:0000250\|UniProtKB:P39007	218..220		1/1 (100%)
		SVSE motif. /evidence=ECO:0000250\|UniProtKB:Q5HTX9	399..402		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..526		6/38 (16%)
		WWDYG motif. /evidence=ECO:0000250\|UniProtKB:P39007	601..605		3/3 (100%)
		Interacts with target acceptor peptide in protein substrate. /evidence=ECO:0000250\|UniProtKB:B9KDD4	601..603		1/1 (100%)
		DK motif. /evidence=ECO:0000250\|UniProtKB:P39007	668..675		6/6 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62160
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001875
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100521
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1409
SonicParanoid	1	1.000	-	-		X1235
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750