DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stt3A and STT3A

DIOPT Version :9

Sequence 1:	NP_001259751.2	Gene:	Stt3A / 33082	FlyBaseID:	FBgn0031149	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001265432.1	Gene:	STT3A / 3703	HGNCID:	6172	Length:	705	Species:	Homo sapiens

Alignment Length:	701	Identity:	541/701 - (77%)
Similarity:	615/701 - (87%)	Gaps:	7/701 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LTWDKQEHLVKLAILILAAVLSFATRLFSVLRFESVIHEFDPYFNYRTTRFLAEQGFYKFHNWFD 77
            |:::||:.|:||.||.:||||||:||||:|||||||||||||||||||||||||:||||||||||
Human     9 LSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRTTRFLAEEGFYKFHNWFD 73

  Fly    78 DRAWYPLGRIIGGTIYPGLMLTSAALYRLMWLLNVTIDIRNVCVFLAPFFSSLTTLVTYALTKEI 142
            ||||||||||||||||||||:||||:|.::...::|||||||||||||.|||.||:|||.||||:
Human    74 DRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFFHITIDIRNVCVFLAPLFSSFTTIVTYHLTKEL 138

  Fly   143 HSTGAGLVAAALISIVPGYISRSVAGSYDNEGIAIFCMLFTYYLWIKAVKTGTIFWSAMSALAYF 207
            ...||||:|||:|::||||||||||||||||||||||||.|||:||||||||:|.|:|..|||||
Human   139 KDAGAGLLAAAMIAVVPGYISRSVAGSYDNEGIAIFCMLLTYYMWIKAVKTGSICWAAKCALAYF 203

  Fly   208 YMVSSWGGYVFLINLIPLHVLALMITGRFSHRIYIAYSTLYCVGTILSMQISFVGFQPIQSSEHM 272
            |||||||||||||||||||||.||:|||||||||:||.|:||:|||||||||||||||:.|||||
Human   204 YMVSSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAYCTVYCLGTILSMQISFVGFQPVLSSEHM 268

  Fly   273 LALGTFGLCQIHAFVDYLRSRIPKDHFDLLFKTLVSSVLTVVFVVGTLLTLTGKVSPWTGRFYSL 337
            .|.|.|||||||||||||||::....|::||::::|.|..|:..||.||.||||:||||||||||
Human   269 AAFGVFGLCQIHAFVDYLRSKLNPQQFEVLFRSVISLVGFVLLTVGALLMLTGKISPWTGRFYSL 333

  Fly   338 LDPSYAKNHIPIIASVSEHQPTSWSSFYFDLQILVFLFPAGLYFCFSKLTDSNIFIILYGVTSIY 402
            ||||||||:|||||||||||||:|||:|||||:|||:||.|||:|||.|:|:.||||:|||||:|
Human   334 LDPSYAKNNIPIIASVSEHQPTTWSSYYFDLQLLVFMFPVGLYYCFSNLSDARIFIIMYGVTSMY 398

  Fly   403 FAGVMVRLMLVLAPVMCVLSGIAISHLLAKYIKSVDAGSSSKQGVESKRQHKKLEQQTGGVKSEV 467
            |:.||||||||||||||:||||.:|.:|:.|:|::|.....|:.       ||.:..|..:|:||
Human   399 FSAVMVRLMLVLAPVMCILSGIGVSQVLSTYMKNLDISRPDKKS-------KKQQDSTYPIKNEV 456

  Fly   468 AIGFVGVITLMLIVYTLHCTWVTSEAYSSPSIVLSARSHDGGRIIFDDFREAYYWLQMNTPEDAR 532
            |.|.:.|:...||.||.|.||||||||||||||||||..||.||||||||||||||:.||||||:
Human   457 ASGMILVMAFFLITYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAK 521

  Fly   533 IMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASSEEKAYEIMRELDVDYVLVIFGGLT 597
            :|||||||||||||||||||||||||||||||||||||||:|||||||||||||.||||||||||
Human   522 VMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLT 586

  Fly   598 GYSSDDINKFLWMVRIGGSTDRGAHIREKDYYAANGEFRVDKEGSPTLLNCLMYKMCYYRFGQMY 662
            |||||||||||||||||||||.|.||:|.|||...||||||:||||.||||||||||||||||:|
Human   587 GYSSDDINKFLWMVRIGGSTDTGKHIKENDYYTPTGEFRVDREGSPVLLNCLMYKMCYYRFGQVY 651

  Fly   663 TEGGKAQGYDRVRAAEIGNKDFELDVMEEAYTTEHWLVRIYKVKDLPNRGV 713
            ||..:..|:||||.||||||||||||:|||||||||||||||||||.|||:
Human   652 TEAKRPPGFDRVRNAEIGNKDFELDVLEEAYTTEHWLVRIYKVKDLDNRGL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stt3A	NP_001259751.2	Stt3	19..712	CDD:224206	536/692 (77%)
Stt3A	NP_001259751.2	STT3	21..495	CDD:280649	347/473 (73%)
STT3A	NP_001265432.1	STT3	17..484	CDD:396873	347/473 (73%)
		DXD motif 1. /evidence=ECO:0000250\|UniProtKB:Q5HTX9	47..49		1/1 (100%)
		DXD motif 2. /evidence=ECO:0000250\|UniProtKB:P39007	167..169		1/1 (100%)
		SVSE motif. /evidence=ECO:0000250\|UniProtKB:Q5HTX9	348..351		2/2 (100%)
		WWDYG motif. /evidence=ECO:0000250\|UniProtKB:P39007	525..529		3/3 (100%)
		Interacts with target acceptor peptide in protein substrate. /evidence=ECO:0000250\|UniProtKB:B9KDD4	525..527		1/1 (100%)
		DK motif. /evidence=ECO:0000250\|UniProtKB:P39007	592..599		6/6 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147365
Domainoid	1	1.000	726	1.000	Domainoid score	I107
eggNOG	1	0.900	-	-		E1_COG1287
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40617
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I222
Isobase	1	0.950	-	0	Normalized mean entropy	S482
OMA	1	1.010	-	-		QHG62160
OrthoDB	1	1.010	-	-		D111618at33208
OrthoFinder	1	1.000	-	-		FOG0001875
OrthoInspector	1	1.000	-	-		oto90751
orthoMCL	1	0.900	-	-		OOG6_100521
Panther	1	1.100	-	-	LDO	PTHR13872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1409
SonicParanoid	1	1.000	-	-		X1235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750