DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf150 and RNF150

DIOPT Version :9

Sequence 1:	XP_017168354.1	Gene:	Rnf150 / 330812	MGIID:	2443860	Length:	450	Species:	Mus musculus
Sequence 2:	XP_005263207.1	Gene:	RNF150 / 57484	HGNCID:	23138	Length:	460	Species:	Homo sapiens

Alignment Length:	474	Identity:	415/474 - (87%)
Similarity:	423/474 - (89%)	Gaps:	38/474 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MTMSLIQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYLE--PEPGAAVAGSGGG 63
            |.|||||||.||||||||||||||||||||||||||||||||||||||.|  |:|||..|| |||
Human     1 MAMSLIQACCSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYAEPAPDPGAGAAG-GGG 64

Mouse    64 AELHTEKSECGRYGEHSPKQDARGEVVMASSAQDRLACDPNTKFAAPAHGKHWIALIPKGNCTYR 128
            |||||||:||||||||||||||||||||||||.||||||||||||||..||:|||||||||||||
Human    65 AELHTEKTECGRYGEHSPKQDARGEVVMASSAHDRLACDPNTKFAAPTRGKNWIALIPKGNCTYR 129

Mouse   129 DKIRNAFLQNASAVVIFNVGSNTNETITMPHA----------------------GVEDIVAIMIP 171
            ||||||||||||||||||||||||||||||||                      |||||||||||
Human   130 DKIRNAFLQNASAVVIFNVGSNTNETITMPHAGLMSSHAQPLKLISPCPYSLSSGVEDIVAIMIP 194

Mouse   172 EPKGKEIVSLLERNITVTMYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRY 236
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   195 EPKGKEIVSLLERNITVTMYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRY 259

Mouse   237 ANARDRNQYTIATGQDWQLYRRRLGDAAKKAISKLQVRTIRKGDKETESDFDNCAVCIEGYKPND 301
            ||||||||             |||||||||||||||:|||:||||||||||||||||||||||||
Human   260 ANARDRNQ-------------RRLGDAAKKAISKLQIRTIKKGDKETESDFDNCAVCIEGYKPND 311

Mouse   302 VVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALGIPPNADCMDDLPIDFEGSLGGPPTNQI 366
            ||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
Human   312 VVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALGIPPNADCMDDLPTDFEGSLGGPPTNQI 376

Mouse   367 TGASDTTVNESSVTLDPAVRTVGALQVVQDPDPAPQEGEAIFTTNSGQEPALSSDSDISLIMALE 431
            ||||||||||||||||||||||||||||||.||.||||:.||||||.||||:|||||||||||:|
Human   377 TGASDTTVNESSVTLDPAVRTVGALQVVQDTDPIPQEGDVIFTTNSEQEPAVSSDSDISLIMAME 441

Mouse   432 VGLSDVELSTDQDCEEVKS 450
            |||||||||||||||||||
Human   442 VGLSDVELSTDQDCEEVKS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf150	XP_017168354.1	PA_GRAIL_like	45..192	CDD:239037	136/170 (80%)
Rnf150	XP_017168354.1	RING-H2_GRAIL	289..336	CDD:319582	46/46 (100%)
RNF150	XP_005263207.1	PA_GRAIL_like	45..215	CDD:239037	136/170 (80%)
		UPF0233	<229..>254	CDD:299753	24/24 (100%)
		zf-RING_2	298..341	CDD:290367	42/42 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83955180
Domainoid	1	1.000	223	1.000	Domainoid score	I22549
eggNOG	1	0.900	-	-		E33208_3BHU7
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33783
Inparanoid	1	1.050	835	1.000	Inparanoid score	I7533
Isobase	1	0.950	-	0	Normalized mean entropy	S3321
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50669
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto121555
orthoMCL	1	0.900	-	-		OOG6_107948
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	20	20.250