DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf150 and rnf150a

DIOPT Version :9

Sequence 1:	XP_017168354.1	Gene:	Rnf150 / 330812	MGIID:	2443860	Length:	450	Species:	Mus musculus
Sequence 2:	NP_001139044.1	Gene:	rnf150a / 559804	ZFINID:	ZDB-GENE-060213-1	Length:	418	Species:	Danio rerio

Alignment Length:	452	Identity:	306/452 - (67%)
Similarity:	352/452 - (77%)	Gaps:	36/452 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MTMSLIQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYLEPEPGAAVAGSGGGAE 65
            |.:||.|||||||||||||||||||||||||||||||||||||||||||:|..          :|
Zfish     1 MVVSLTQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYLDPVT----------SE 55

Mouse    66 LHTEKSECGRYGEHSPKQDARGEVVMASSAQDRLACDPNTKFAAPAHGKHWIALIPKGNCTYRDK 130
            :.|::||||||||||||:||||.|.|   .|||.|||.||:|..|.....|||||.|||||:|:|
Zfish    56 IKTDRSECGRYGEHSPKRDARGFVFM---PQDRQACDGNTRFPLPHPSIPWIALIAKGNCTFREK 117

Mouse   131 IRNAFLQNASAVVIFNVG-SNTNETITMPHAGVEDIVAIMIPEPKGKEIVSLLERNITVTMYITI 194
            ||:|...||||||||||| ||:|:||||||.|..|:||||||||||:||::|||:||||.|:|:|
Zfish   118 IRHAAALNASAVVIFNVGSSNSNDTITMPHHGTGDVVAIMIPEPKGREIMALLEKNITVAMHISI 182

Mouse   195 GTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRNQYTIATGQDWQLYRRR 259
            ||||||||||||||||||||||||||||||||||||||||||||||||:|             ||
Zfish   183 GTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRSQ-------------RR 234

Mouse   260 LGDAAKKAISKLQVRTIRKGDKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDH 324
            ||||||||||||||||||||||||:|||||||||||.||||||||||||||:||::||||||.||
Zfish   235 LGDAAKKAISKLQVRTIRKGDKETDSDFDNCAVCIEDYKPNDVVRILPCRHVFHRNCVDPWLQDH 299

Mouse   325 RTCPMCKMNILKALGIPPNADCMDDLPIDFEGSLGGPPTNQITGASDTTVNESSVTLDPAVRTVG 389
            |||||||||||||||||||.||.||.|.|:|.| .|.|:..:||||:.:|.|||:.||..:|..|
Zfish   300 RTCPMCKMNILKALGIPPNTDCSDDAPPDYETS-SGQPSIAVTGASEVSVGESSLVLDQPLRITG 363

Mouse   390 ALQVVQDPDPAPQEGEAIFTTNSGQ-EPALSSDSDISLIMALEVGLSDVELSTDQDCEEVKS 450
            .....|:.:..|.:.|:....:|.| :|::|:|.|   ||.:|:    .||.:|.:.|:|||
Zfish   364 LSHDYQEMNSVPADAESPHIASSEQHQPSMSNDPD---IMPMEI----AELQSDLEQEDVKS 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf150	XP_017168354.1	PA_GRAIL_like	45..192	CDD:239037	93/147 (63%)
Rnf150	XP_017168354.1	RING-H2_GRAIL	289..336	CDD:319582	41/46 (89%)
rnf150a	NP_001139044.1	PA_GRAIL_like	45..180	CDD:239037	93/147 (63%)
		UPF0233	<194..>219	CDD:299753	24/24 (100%)
		zf-RING_2	263..306	CDD:290367	37/42 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C193129814
Domainoid	1	1.000	89	1.000	Domainoid score	I27927
eggNOG	1	0.900	-	-		E33208_3BHU7
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33783
Inparanoid	1	1.050	592	1.000	Inparanoid score	I5332
OMA	1	1.010	-	-		QHG50669
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto52489
orthoMCL	1	0.900	-	-		OOG6_107948
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300