DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf150 and H10E21.5

DIOPT Version :9

Sequence 1:	XP_017168354.1	Gene:	Rnf150 / 330812	MGIID:	2443860	Length:	450	Species:	Mus musculus
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	172	Identity:	87/172 - (50%)
Similarity:	117/172 - (68%)	Gaps:	28/172 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse   204 SRTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRNQYTIATGQDWQLYRRRLGDAAKKAI 268
            |:|||:|||||||:||:||||||||||:||||||:|:||.|             |||.:||:||:
Worm   156 SKTSVLFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQ-------------RRLFNAARKAL 207

Mouse   269 SKLQVRTIRKG-DKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKM 332
            :::...||..| .:|.:||   ||||::.|:..||:|:|||:|::||||:|||||:||||||||.
Worm   208 TRIPTMTITPGMTQELQSD---CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKN 269

Mouse   333 NILKALGIPPNADCMDDLPIDFEGSLGGPPTNQITGASDTTV 374
            :|||..|.      .:|:..|.:     .|||....|.|.|:
Worm   270 DILKHFGY------WNDIRNDIQ-----MPTNSRGIADDFTI 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf150	XP_017168354.1	PA_GRAIL_like	45..192	CDD:239037
Rnf150	XP_017168354.1	RING-H2_GRAIL	289..336	CDD:319582	30/46 (65%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	87/172 (51%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	31/49 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C163567035
Domainoid	1	1.000	84	1.000	Domainoid score	I5750
eggNOG	1	0.900	-	-		E33208_3BHU7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3321
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		otm16989
orthoMCL	1	0.900	-	-		OOG6_107948
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.680