DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbs and CYS4

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_011671.3	Gene:	CYS4 / 853059	SGDID:	S000003387	Length:	507	Species:	Saccharomyces cerevisiae

Alignment Length:	504	Identity:	212/504 - (42%)
Similarity:	300/504 - (59%)	Gaps:	55/504 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 NILEVIGCTPLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPG-YTI 111
            |:::::|.|||:.|..:|.:.||:.::|||.|..|||||:||||...||::||..|.:.|. .|:
Yeast    13 NVIDLVGNTPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIHPSRSTL 77

  Fly   112 IEPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVA 176
            |||||||||||||:..|:|||:.||.:||||||||||.|:.|||:||||||.||:||||..|.||
Yeast    78 IEPTSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVA 142

  Fly   177 QQLQRETPNSIVLDQYRNAGNPLAHYDGTAAEILWQLD-----NKVDMIVVSAGTAGTISGIGRK 236
            ::|::|.|.:::||||.|..||.|||.||..||..||:     :.:..:|..|||.||||||.:.
Yeast   143 KKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKY 207

  Fly   237 IKEQVPSCQIVGVDPYGSILARPAELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGDSDCF 301
            :|||....||||.||:|||||:|..|||||:..|:||||||||.|.|.|..::|||.|..|...|
Yeast   208 LKEQNDKIQIVGADPFGSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSF 272

  Fly   302 PMSRRLNAEEGLLCGGSSGGAMHAALEHAR---KLKKGQRCVVILPDGIRNYMTKFVSDNWMEAR 363
            ..:|:|.:.||:|.|||||.|..|.:::..   :|.:....|.|.||.||:|:||||.|.|::..
Yeast   273 KYARQLISNEGVLVGGSSGSAFTAVVKYCEDHPELTEDDVIVAIFPDSIRSYLTKFVDDEWLKKN 337

  Fly   364 N--------------FKEPVNEHGHWWWSLAIAELELPAPPVILKSDATVGEAIALMKKHRVDQL 414
            |              .:....::...:.:..:.:|.| .|.|.:|..|.|.:.|.::|.:..|||
Yeast   338 NLWDDDVLARFDSSKLEASTTKYADVFGNATVKDLHL-KPVVSVKETAKVTDVIKILKDNGFDQL 401

  Fly   415 PVVDQDDGSVLGVVGQETLITQIVSMNRQQSDPAIKA-------LN---------------KRVI 457
            ||: .:||.:.|:|....|:.:: |:|...:|..||.       ||               |:.|
Yeast   402 PVL-TEDGKLSGLVTLSELLRKL-SINNSNNDNTIKGKYLDFKKLNNFNDVSSYNENKSGKKKFI 464

  Fly   458 RLNESEILGKLARVLEVDPSVLIL-GKNPAGKVELKALATKLDVTTFIA 505
            :.:|:..|..|.|..|.:.|.:|. |..|.      .:.||:|:.:::|
Yeast   465 KFDENSKLSDLNRFFEKNSSAVITDGLKPI------HIVTKMDLLSYLA 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	211/502 (42%)
		CBS_like	54..352	CDD:107204	163/306 (53%)
		CBS_pair_PALP_assoc	386..504	CDD:239981	39/140 (28%)
CYS4	NP_011671.3	cysta_beta	10..507	CDD:273464	211/502 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344387
Domainoid	1	1.000	304	1.000	Domainoid score	I213
eggNOG	1	0.900	-	-		E1_COG0031
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37258
Inparanoid	1	1.050	358	1.000	Inparanoid score	I384
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54083
OrthoFinder	1	1.000	-	-		FOG0000642
OrthoInspector	1	1.000	-	-		oto100290
orthoMCL	1	0.900	-	-		OOG6_100154
Panther	1	1.100	-	-	LDO	PTHR10314
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R286
SonicParanoid	1	1.000	-	-		X341
TreeFam	1	0.960	-	-
	15	14.790