DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbs and MCY1

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_011526.1	Gene:	MCY1 / 852895	SGDID:	S000003244	Length:	393	Species:	Saccharomyces cerevisiae

Alignment Length:	361	Identity:	108/361 - (29%)
Similarity:	169/361 - (46%)	Gaps:	66/361 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EVIGCTPLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLL---KPGYTII 112
            |:||.|||||:.::..:.|:  .:|||.|..||.||.|||:...:::.|||.|.|   :||: :.
Yeast    51 ELIGNTPLVKIRSLTKATGV--NIYAKLELCNPAGSAKDRVALNIIKTAEELGELVRGEPGW-VF 112

  Fly   113 EPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQ 177
            |.|||:|||.:|:.|...||:..|.:|:..|.||::.|.:|||.:.:....:..| |...:..|:
Yeast   113 EGTSGSTGISIAVVCNALGYRAHISLPDDTSLEKLALLESLGATVNKVKPASIVD-PNQYVNAAK 176

  Fly   178 QLQRETPNS------IVLDQYRNAGNPLAHYDGTAAEILWQLDNKVDMIVVSAGTAGTISGIGRK 236
            :...|...|      :..||:.|..|...||..|..||..|....:|..:...||.|||:|:.:.
Yeast   177 KACNELKKSGNGIRAVFADQFENEANWKVHYQTTGPEIAHQTKGNIDAFIAGCGTGGTITGVAKF 241

  Fly   237 IKE--QVPSCQIVGVDPYGSILARPAELNKTDVQFYE-------------------------VEG 274
            :||  ::| |.:|..||.||             .||.                         |||
Yeast   242 LKERAKIP-CHVVLADPQGS-------------GFYNRVNYGVMYDYVEKEGTRRRHQVDTIVEG 292

  Fly   275 IG-----YDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLLCGGSSGGAMHAALEHARKLK 334
            ||     ::|.   ..:..:|...::.|:....|::.|:..:||..|.|:.....||::.|:.|.
Yeast   293 IGLNRITHNFH---MGEKFIDESIRVNDNQAIRMAKYLSVNDGLFVGSSTAINAVAAIQVAKTLP 354

  Fly   335 KGQRCVVILPDGIRNYMTKFVSDNWMEARNFKEPVN 370
            .|...|:|..|....:::||    |.||:.....|:
Yeast   355 HGSNIVIIACDSGSRHLSKF----WKEAKEIDHDVS 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	108/361 (30%)
		CBS_like	54..352	CDD:107204	100/338 (30%)
		CBS_pair_PALP_assoc	386..504	CDD:239981
MCY1	NP_011526.1	CBS_like	54..372	CDD:107204	100/338 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0031
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100154
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X341
TreeFam	0	0.000	Not matched by this tool.
	4	3.710