DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbs and DES1

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001330587.1	Gene:	DES1 / 832873	AraportID:	AT5G28030	Length:	323	Species:	Arabidopsis thaliana

Alignment Length:	334	Identity:	121/334 - (36%)
Similarity:	179/334 - (53%)	Gaps:	21/334 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RQQITPNILEVIGCTPLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLK 106
            |..|..::.|:||.||:|.||.|  .||....:.||.|.:.|..|:||||.|.|::|||::||:.
plant     4 RVLIKNDVTELIGNTPMVYLNKI--VDGCVARIAAKLEMMEPCSSIKDRIAYSMIKDAEDKGLIT 66

  Fly   107 PG-YTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPE 170
            || .|:||.|.||||||||...|.:|||.|::||..||.|:...||.|||::..|......   :
plant    67 PGKSTLIEATGGNTGIGLASIGASRGYKVILLMPSTMSLERRIILRALGAEVHLTDISIGI---K 128

  Fly   171 GLIYVAQQLQRETPNSIVLDQYRNAGNPLAHYDGTAAEILWQLDNKVDMIVVSAGTAGTISGIGR 235
            |.:..|:::..:||...:..|:.|..||..||..|..||......|||::|...||.||::|.|:
plant   129 GQLEKAKEILSKTPGGYIPHQFINPENPEIHYRTTGPEIWRDSAGKVDILVAGVGTGGTVTGTGK 193

  Fly   236 KIKEQVPSCQIVGVDPYGSIL---ARPAELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGD 297
            .:||:....::..|:|..|.:   .:|..        :.::|||....|...|.::||...::..
plant   194 FLKEKNKDIKVCVVEPSESAVLSGGKPGP--------HLIQGIGSGEIPANLDLSIVDEIIQVTG 250

  Fly   298 SDCFPMSRRLNAEEGLLCGGSSGGAMHAALEHARKLKK-GQRCVVILPDGIRNYM-TKFVSDNWM 360
            .:....::.|..:||||.|.|||.:..|||:.|::.:. |:..|||.|.|...|: |:.......
plant   251 EEAIETTKLLAIKEGLLVGISSGASAAAALKVAKRPENVGKLIVVIFPSGGERYLSTELFESVRY 315

  Fly   361 EARNFKEPV 369
            ||.|.  ||
plant   316 EAENL--PV 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	120/331 (36%)
		CBS_like	54..352	CDD:107204	111/303 (37%)
		CBS_pair_PALP_assoc	386..504	CDD:239981
DES1	NP_001330587.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	206	1.000	Domainoid score	I821
eggNOG	1	0.900	-	-		E1_COG0031
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I1254
OMA	1	1.010	-	-		QHG54083
OrthoDB	1	1.010	-	-		D1016546at2759
OrthoFinder	1	1.000	-	-		FOG0000642
OrthoInspector	1	1.000	-	-		otm2614
orthoMCL	1	0.900	-	-		OOG6_100154
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.780