DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbs and CS26

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_187013.1	Gene:	CS26 / 821203	AraportID:	AT3G03630	Length:	404	Species:	Arabidopsis thaliana

Alignment Length:	354	Identity:	120/354 - (33%)
Similarity:	178/354 - (50%)	Gaps:	43/354 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GKPSKCKWHLGTAEKS--------PHIHRGIAHRQQI----TPNILE----VIGCTPLVKLNNIP 65
            ||.|     .||..||        |.....:|..|.|    |.||.|    :||.||:|.||.:
plant    60 GKSS-----TGTKSKSKTKRKPPPPPPVTTVAEEQHIAESETVNIAEDVTQLIGSTPMVYLNRV- 118

  Fly    66 ASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPGYTI-IEPTSGNTGIGLAMACAV 129
             :||...::.||.|.:.|..|||||||..|:.:||..|.:.|..|: :|||:||||:|:|...|.
plant   119 -TDGCLADIAAKLESMEPCRSVKDRIGLSMINEAENSGAITPRKTVLVEPTTGNTGLGIAFVAAA 182

  Fly   130 KGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETPNSIVLDQYRN 194
            ||||.|:.||..::.|:...||.|||:|:.|..|...   :|.:..|:::..:|.|:.:..|:.|
plant   183 KGYKLIVTMPASINIERRMLLRALGAEIVLTNPEKGL---KGAVDKAKEIVLKTKNAYMFQQFDN 244

  Fly   195 AGNPLAHYDGTAAEILWQLDNKVDMIVVSAGTAGTISGIGRKIKEQVPSCQIVGVDPYGSILARP 259
            ..|...|::.|..||.......||:.|...||.||::|.|..:|......::|||:|
plant   245 TANTKIHFETTGPEIWEDTMGNVDIFVAGIGTGGTVTGTGGFLKMMNKDIKVVGVEP-------- 301

  Fly   260 AELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLLCGGSSGGAMH 324
               ::..|    :.|....:.|.:.|..::|...|:.:.:...|:|||..|||||.|.|||.|..
plant   302 ---SERSV----ISGDNPGYLPGILDVKLLDEVFKVSNGEAIEMARRLALEEGLLVGISSGAAAV 359

  Fly   325 AALEHARKLKK-GQRCVVILPDGIRNYMT 352
            ||:..|::.:. |:...|:.|.....|:|
plant   360 AAVSLAKRAENAGKLITVLFPSHGERYIT 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	110/318 (35%)
		CBS_like	54..352	CDD:107204	103/299 (34%)
		CBS_pair_PALP_assoc	386..504	CDD:239981
CS26	NP_187013.1	PLN02565	95..404	CDD:166206	109/314 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	206	1.000	Domainoid score	I821
eggNOG	1	0.900	-	-		E1_COG0031
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I1254
OMA	1	1.010	-	-		QHG54083
OrthoDB	1	1.010	-	-		D1016546at2759
OrthoFinder	1	1.000	-	-		FOG0000642
OrthoInspector	1	1.000	-	-		otm2614
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.880