DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbs and cbsa

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001104702.1	Gene:	cbsa / 550524	ZFINID:	ZDB-GENE-050417-367	Length:	571	Species:	Danio rerio

Alignment Length:	529	Identity:	269/529 - (50%)
Similarity:	351/529 - (66%)	Gaps:	15/529 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PQPKPYERPAD--FIDPGKPSKCKWHLGTA-EKSPHIHRGIAHRQQITPNILEVIGCTPLVKLNN 63
            ||.......||  :|.|..||:|.|..|.: |.|||.:......:.|.||||..||.||||.:|.
Zfish    41 PQLNKEIATADPKWIRPDLPSRCTWKPGMSHENSPHTYFPRTKAECILPNILGKIGDTPLVHINK 105

  Fly    64 IPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPGYTIIEPTSGNTGIGLAMACA 128
            |....|::||:.|||||.|.||||||||..|||:|||.:|:|.||.|||||||||||||||:|.|
Zfish   106 ISKIFGLKCELLAKCEFFNAGGSVKDRISLRMVEDAEREGILNPGDTIIEPTSGNTGIGLALAAA 170

  Fly   129 VKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETPNSIVLDQYR 193
            ||||:||||||||||.|||..||.|||:|:||||.|.:||||..:.||.:|:.|.|||.:|||||
Zfish   171 VKGYRCIIVMPEKMSMEKVDVLRALGAEIVRTPTSARFDSPESHVGVAWRLKNEIPNSHILDQYR 235

  Fly   194 NAGNPLAHYDGTAAEILWQLDNKVDMIVVSAGTAGTISGIGRKIKEQVPSCQIVGVDPYGSILAR 258
            |..|||||||.||.|||.|.|.||||:|..|||.|||:||.||:||:.|:.:||.|||.|||||.
Zfish   236 NPSNPLAHYDTTAEEILEQCDGKVDMLVAGAGTGGTITGIARKLKEKCPNIKIVAVDPEGSILAE 300

  Fly   259 PAELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLLCGGSSGGAM 323
            |.|||:||...||||||||||.|||.|.::||.|.|..|.:.|.|:|.|..:||||||||||.||
Zfish   301 PDELNRTDKNQYEVEGIGYDFIPTVLDRSLVDKWYKSKDEESFAMARMLIRDEGLLCGGSSGTAM 365

  Fly   324 HAALEHARKLKKGQRCVVILPDGIRNYMTKFVSDNWMEARNF--KEPVNEHGHWWWSLAIAELEL 386
            .||::.|::||:||||||||||.|||||:||:||.||..:.|  .|.:..:..|||:|.:..|.|
Zfish   366 AAAVKFAKELKEGQRCVVILPDSIRNYMSKFLSDKWMFQKGFLRVEDIMVNKPWWWNLKLQSLNL 430

  Fly   387 PAPPVILKSDATVGEAIALMKKHRVDQLPVVDQDDGSVLGVVGQETLITQIVSMNRQQSDPAIKA 451
            .||..:|.: .|..:.|.::|....||.|||: :.|.:||:|....::..:::...:.|||..|.
Zfish   431 SAPLTVLPT-VTCQKTIKILKDKGFDQAPVVN-EAGLILGMVTLGNMLASVLAGKVKPSDPVSKV 493

  Fly   452 LNKRVIRLNESEILGKLARVLEVDPSVLILGK--------NPAGKVELKALATKLDVTTFIAAGK 508
            |.|:..::..::.:|||:|:||.|...|::.:        :.:.|..:..:.|.:|:..|:.|.:
Zfish   494 LYKQFKQIRLTDNMGKLSRILETDHFALVVHEQIQYLTDGSSSQKQMVFGVVTAIDLLNFVTARE 558

  Fly   509 QKPKANGTT 517
            ::.:....|
Zfish   559 KRERTMSET 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	252/469 (54%)
		CBS_like	54..352	CDD:107204	198/297 (67%)
		CBS_pair_PALP_assoc	386..504	CDD:239981	33/125 (26%)
cbsa	NP_001104702.1	cysta_beta	87..554	CDD:273464	251/468 (54%)
		CBS_like	96..394	CDD:107204	198/297 (67%)
		CBS_pair_PALP_assoc	430..554	CDD:239981	33/125 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583652
Domainoid	1	1.000	392	1.000	Domainoid score	I745
eggNOG	1	0.900	-	-		E1_COG0031
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37258
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1297
OMA	1	1.010	-	-		QHG54083
OrthoDB	1	1.010	-	-		D1016546at2759
OrthoFinder	1	1.000	-	-		FOG0000642
OrthoInspector	1	1.000	-	-		otm24607
orthoMCL	1	0.900	-	-		OOG6_100154
Panther	1	1.100	-	-	LDO	PTHR10314
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R286
SonicParanoid	1	1.000	-	-		X341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800