DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbs and cbsb

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001014367.2	Gene:	cbsb / 266987	ZFINID:	ZDB-GENE-021030-3	Length:	597	Species:	Danio rerio

Alignment Length:	511	Identity:	266/511 - (52%)
Similarity:	347/511 - (67%)	Gaps:	13/511 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FIDPGKPSKCKWHLGTAE-KSPHIHRGIAHRQQITPNILEVIGCTPLVKLNNIPASDGIECEMYA 76
            :|.|..||:|.|.||... :|||.|........|.||||..||.||:|::|.||.:.|::||:.|
Zfish    78 WIRPDLPSRCTWKLGDLNMESPHNHYQRTKTSGILPNILSKIGETPMVRMNKIPKAFGLKCELLA 142

  Fly    77 KCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPGYTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEK 141
            ||||.|.||||||||..||::|||..|.||||.|||||||||||||||:|.|||||:||||||||
Zfish   143 KCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEK 207

  Fly   142 MSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETPNSIVLDQYRNAGNPLAHYDGTA 206
            ||.|||..||.|||:|:||||.|.:||||..:.||.:|:.|.||:.:||||||..|||||||.||
Zfish   208 MSMEKVDVLRALGAEIVRTPTSARFDSPESHVGVAWRLKNEIPNAHILDQYRNPSNPLAHYDTTA 272

  Fly   207 AEILWQLDNKVDMIVVSAGTAGTISGIGRKIKEQVPSCQIVGVDPYGSILARPAELNKTDVQFYE 271
            .|||.|...|:||:|..|||.|||:||.||:||:.|..:|:||||.|||||.|.||||||...||
Zfish   273 EEILEQCGGKIDMLVAGAGTGGTITGIARKLKEKCPDIKIIGVDPEGSILAEPDELNKTDKTQYE 337

  Fly   272 VEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLLCGGSSGGAMHAALEHARKLKKG 336
            ||||||||.|||.|.:|||.|.|..|.:.|.|||.|..|||||||||||.||.||:..|::||:|
Zfish   338 VEGIGYDFIPTVLDRSVVDNWYKSNDEESFAMSRMLIREEGLLCGGSSGTAMSAAVNVAKELKEG 402

  Fly   337 QRCVVILPDGIRNYMTKFVSDNWMEARNF--KEPVNEHGHWWWSLAIAELELPAPPVILKSDATV 399
            |||||||||.|||||:||:||.||..:.|  :|.:..:..|||:|.:.||.|.||..:|.. .::
Zfish   403 QRCVVILPDSIRNYMSKFLSDKWMFEKGFMSEEDLVVNKPWWWNLTLQELRLSAPLTVLPL-VSI 466

  Fly   400 GEAIALMKKHRVDQLPVVDQDDGSVLGVVGQETLITQIVSMNRQQSDPAIKALNKRVIRLNESEI 464
            .:.|.::|:...||.|||| :.|.:||:|....::..:::...:.|||..|.|.|:..::..::.
Zfish   467 KKTIQILKEKAFDQAPVVD-EAGHILGMVTLGNMLASVLAGKVRPSDPISKVLYKQFKQVRLTDN 530

  Fly   465 LGKLARVLEVDPSVLILGK--------NPAGKVELKALATKLDVTTFIAAGKQKPK 512
            ||||:|:||.|...|::.:        :|..:..:..:.|.:|:..::...:::.:
Zfish   531 LGKLSRILETDHFALVVHEQIQYMSDGSPKMRQMVFGVVTAIDLLNYVTMRERRER 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	254/469 (54%)
		CBS_like	54..352	CDD:107204	199/297 (67%)
		CBS_pair_PALP_assoc	386..504	CDD:239981	34/125 (27%)
cbsb	NP_001014367.2	cysta_beta	111..578	CDD:273464	254/468 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583651
Domainoid	1	1.000	392	1.000	Domainoid score	I745
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37258
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1297
OMA	1	1.010	-	-		QHG54083
OrthoDB	1	1.010	-	-		D1016546at2759
OrthoFinder	1	1.000	-	-		FOG0000642
OrthoInspector	1	1.000	-	-		otm24607
orthoMCL	1	0.900	-	-		OOG6_100154
Panther	1	1.100	-	-	O	PTHR10314
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910