DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbs and cbs-2

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_494215.2	Gene:	cbs-2 / 186197	WormBaseID:	WBGene00018783	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	195/376 - (51%)
Similarity:	248/376 - (65%)	Gaps:	28/376 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KPYERPADFIDPG----KPSKC--KWHLGTAEKSPHIHRGIAHRQQITPNILEVIGCTPLVKLNN 63
            ||. :|.:..||.    .|:|.  :|      ||....|  ..|..:..::|:.||.||||||.:
Worm   299 KPI-KPREIFDPKVLDYDPTKMVGEW------KSSSKFR--PERPLVLDSVLDAIGKTPLVKLQH 354

  Fly    64 IPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPG------YTIIEPTSGNTGIG 122
            :|.:.|:.|.:|.||||||.|||.||||..:||:.||:.|  |||      .|:|||||||||||
Worm   355 VPKAHGVRCNVYVKCEFLNAGGSTKDRIAKKMVEIAEKTG--KPGALTPGATTLIEPTSGNTGIG 417

  Fly   123 LAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETPNSI 187
            |::..||:||||:|.||||||.||.:.|..||:.|:|||.|||::||...|.||.:|:.|.|.::
Worm   418 LSLVAAVRGYKCLITMPEKMSKEKSTTLSVLGSTIVRTPNEAAFNSPSSHIGVALRLKHEIPGAV 482

  Fly   188 VLDQYRNAGNPLAHYDGTAAEILWQL-DNKVDMIVVSAGTAGTISGIGRKIKEQVPSCQIVGVDP 251
            :||||.|.|||||||:.||.||||.: |.|:|::|:.|||.|||:||.|||.|:.|:..:|||||
Worm   483 ILDQYCNPGNPLAHYEETAEEILWDMGDRKIDLVVLGAGTGGTITGISRKIHERRPNAIVVGVDP 547

  Fly   252 YGSILARPAELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLLCG 316
            .||||..|......|  |||||||||||.|...|:..||.|.|..|.:.|.|:|.:...||:|||
Worm   548 NGSILTGPTTGPAPD--FYEVEGIGYDFIPGTLDEKSVDSWLKSDDKESFLMAREIIRTEGILCG 610

  Fly   317 GSSGGAMHAALEHARK--LKKGQRCVVILPDGIRNYMTKFVSDNWMEARNF 365
            ||||.|:|.|||..||  |.:....||:||||||||:|||:.|:||:||.|
Worm   611 GSSGCAVHYALEQCRKLDLPEDANVVVLLPDGIRNYLTKFLDDDWMKARGF 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	183/330 (55%)
		CBS_like	54..352	CDD:107204	172/306 (56%)
		CBS_pair_PALP_assoc	386..504	CDD:239981
cbs-2	NP_494215.2	Trp-synth-beta_II	21..290	CDD:294246
		PALP	21..280	CDD:278708
		PLN02565	340..653	CDD:166206	177/316 (56%)
		CBS_like	345..648	CDD:107204	172/306 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160997
Domainoid	1	1.000	332	1.000	Domainoid score	I605
eggNOG	1	0.900	-	-		E1_COG0031
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016546at2759
OrthoFinder	1	1.000	-	-		FOG0000642
OrthoInspector	1	1.000	-	-		otm14127
orthoMCL	1	0.900	-	-		OOG6_100154
Panther	1	1.100	-	-	O	PTHR10314
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R286
SonicParanoid	1	1.000	-	-		X341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740