DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbs and cbs-1

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001257091.1	Gene:	cbs-1 / 181215	WormBaseID:	WBGene00013866	Length:	704	Species:	Caenorhabditis elegans

Alignment Length:	379	Identity:	193/379 - (50%)
Similarity:	252/379 - (66%)	Gaps:	22/379 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PQPKPYERPADFI-DPGK--------PSKCKWHLGTAEKSPHIHRGIAHRQQITPNILEVIGCTP 57
            |||.....|...: ||.|        |....|.....|    .::....|..:...:|:.||.||
Worm   330 PQPNSIYDPKVLVYDPTKLAGEWTQDPETKSWSHSEVE----FNKFNPERPLVLDTVLDAIGKTP 390

  Fly    58 LVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAE---EQGLLKPGYTIIEPTSGNT 119
            ||||.:||.:.|::|.:|.|||::|.|||.||||..|||:.||   :.|.|.||.|:||||||||
Worm   391 LVKLQHIPKAHGVKCNVYVKCEYMNAGGSTKDRIAKRMVEIAEKTGKPGKLVPGVTLIEPTSGNT 455

  Fly   120 GIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETP 184
            ||||::|.||:||||||.||:|||.||..|:.:||:.|||||.||.:|||...|.||.:|:.|..
Worm   456 GIGLSLASAVRGYKCIITMPKKMSKEKSIAMASLGSTIIRTPNEAGFDSPHSHIGVALRLKSEIQ 520

  Fly   185 NSIVLDQYRNAGNPLAHYDGTAAEILWQL-DNKVDMIVVSAGTAGTISGIGRKIKEQVPSCQIVG 248
            :::|||||.|.|||||||:.||.||::.: |..:|::|::|||.||::||.|||.|::|:.::||
Worm   521 DAVVLDQYCNPGNPLAHYEETAEEIIYDMGDKHIDLVVLTAGTGGTVTGISRKIHERIPTAKVVG 585

  Fly   249 VDPYGSILARPAELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGL 313
            |||:|||||.|||   ||:.|||||||||||.|...|.:.:|.|.|..|.:.|.|:|.|...||:
Worm   586 VDPHGSILAGPAE---TDIDFYEVEGIGYDFLPGTLDTSAIDYWAKSHDKESFLMARELIRSEGI 647

  Fly   314 LCGGSSGGAMHAALEHARKLK--KGQRCVVILPDGIRNYMTKFVSDNWMEARNF 365
            |||||||.|:|.|||..:.|.  .....||:||||||||:|||:.|:||..|:|
Worm   648 LCGGSSGCAVHYALEECKSLNLPAEANVVVLLPDGIRNYITKFLDDDWMNERHF 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	182/327 (56%)
		CBS_like	54..352	CDD:107204	172/303 (57%)
		CBS_pair_PALP_assoc	386..504	CDD:239981
cbs-1	NP_001257091.1	Trp-synth-beta_II	30..307	CDD:294246
cbs-1	NP_001257091.1	cysta_beta	378..>703	CDD:273464	182/327 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160998
Domainoid	1	1.000	332	1.000	Domainoid score	I605
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016546at2759
OrthoFinder	1	1.000	-	-		FOG0000642
OrthoInspector	1	1.000	-	-		otm14127
orthoMCL	1	0.900	-	-		OOG6_100154
Panther	1	1.100	-	-	LDO	PTHR10314
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R286
SonicParanoid	1	1.000	-	-		X341
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880