DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbs and F13B12.4

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_501928.1	Gene:	F13B12.4 / 177937	WormBaseID:	WBGene00008732	Length:	435	Species:	Caenorhabditis elegans

Alignment Length:	421	Identity:	99/421 - (23%)
Similarity:	167/421 - (39%)	Gaps:	104/421 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KCKWHLGTAEKSPHIHRGIAHRQQITPNILEVIGCTPLVKLN--NIPASDGIECEMYAKCEFLNP 83
            :.||.||..:|..:..|.:.|              ||:.|.:  ..|.:|     ::.|.|....
Worm    39 EAKWRLGAIQKLWNERRKMGH--------------TPMTKFSPPGFPNAD-----IFFKNETATA 84

  Fly    84 GGSVKDRIGYRMVQDAEEQG-LLKPGYTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKV 147
            ..::|.|..:.::..|..:| :......:.:.||||||...|..|.:.......|:.:.:..|||
Worm    85 TRTLKHRFAWALLLWAITEGKVTSKTSAVYDSTSGNTGSAEAYMCTLVNVPYYAVVADNLEKEKV 149

  Fly   148 SALRTLGAKIIRTPT--------EAAYDSPEGLIYVAQQLQRETPNSIVLDQYRNAGNPLAHYDG 204
            ..:.:.|.|||:.|.        |.| |...| .|:.|     ..|:...:::..:|:  .:::.
Worm   150 KQIESFGGKIIKVPVALRNAKAKEFA-DKNHG-FYMNQ-----FGNAEKAEEFHESGD--FYFES 205

  Fly   205 TAA--EILWQLDNKVDMIVV-------SAGTAGTISGIGRKIKEQVPSCQIVGVDPYGSILARPA 260
            |..  ||:.||....:.||.       ||||.||||.:||.:..            ||:    |.
Worm   206 TNVYHEIIVQLKKDKEQIVKIPDYFVHSAGTGGTISSVGRYVAR------------YGA----PT 254

  Fly   261 ELNKTDVQ---FYE--------------------VEGI--GYDFPPTVFDDT------VVDVWTK 294
            ::..:|.|   ||:                    :.||  |||..|..:.:|      |:....|
Worm   255 KVVLSDSQYSLFYDYVIGHKFTNQSGAGIWTPPGIAGIGYGYDIEPVWYGETTSLTRNVIHEAMK 319

  Fly   295 IGDSDCFPMSRRLNAEEGLLCGGSSG----GAMHAALEH-ARK--LKKGQRCVVILPDGIRNYMT 352
            :.|.......|.|: |:|...|.|:.    .:::.|.:: |||  :|.....|.:..|....|.:
Worm   320 MPDIASVATMRILD-EKGYNVGPSTSLNFLVSLYKAYQNKARKSAIKHRLTIVTLACDPGDFYRS 383

  Fly   353 KFVSDNWMEARNFKEPVNEHGHWWWSLAIAE 383
            .::::.|:| ::||:.....|...|...|.|
Worm   384 TYLNNEWVE-KSFKKFGGVMGMECWKKLIQE 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	92/397 (23%)
		CBS_like	54..352	CDD:107204	84/355 (24%)
		CBS_pair_PALP_assoc	386..504	CDD:239981
F13B12.4	NP_501928.1	Trp-synth-beta_II	58..384	CDD:294246	85/370 (23%)
F13B12.4	NP_501928.1	PALP	72..376	CDD:278708	78/334 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0031
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016546at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820