DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbs and cysl-2

DIOPT Version :9

Sequence 1:	NP_001285508.1	Gene:	Cbs / 33081	FlyBaseID:	FBgn0031148	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_497008.1	Gene:	cysl-2 / 175107	WormBaseID:	WBGene00010759	Length:	337	Species:	Caenorhabditis elegans

Alignment Length:	320	Identity:	117/320 - (36%)
Similarity:	179/320 - (55%)	Gaps:	13/320 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 EVIGCTPLVKLNNIPASDGIECEMYAKCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPGYTI-IEP 114
            |:||.|||:|||.|....|  ..:..|.|::||..||||||.:.|:..||:.||:.||.|: |||
Worm    12 ELIGNTPLLKLNKIGKDLG--ASIAVKVEYMNPACSVKDRIAFNMIDTAEKAGLITPGKTVLIEP 74

  Fly   115 TSGNTGIGLAMACAVKGYKCIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQL 179
            ||||.||.||....::|||.|:.||..||.|:...|:..||::|.|....|.   :|.:..|::|
Worm    75 TSGNMGIALAYCGKLRGYKVILTMPASMSIERRCLLKAYGAEVILTDPATAV---KGAVQRAEEL 136

  Fly   180 QRETPNSIVLDQYRNAGNPLAHYDGTAAEILWQLDNKVDMIVVSAGTAGTISGIGRKIKEQVPSC 244
            :...||:.:|:|:.|..||.|||..|..||..|...|||::....|:.||.:|:||.:||:.||.
Worm   137 RDVIPNAYILNQFGNPANPEAHYKTTGPEIWRQTQGKVDIVCFGVGSGGTCTGVGRFLKEKNPSV 201

  Fly   245 QIVGVDPYGSILARPAELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNA 309
            |:..|:|:.|     :.:|......::::|:|....|.:.|.|:.....::...|...|:::|..
Worm   202 QVFPVEPFES-----SVINGLPHSPHKIQGMGTGMIPDILDLTLFSEALRVHSDDAIAMAKKLAD 261

  Fly   310 EEGLLCGGSSGGAMHAALEHARKLK-KGQRCVVILPD-GIRNYMTKFVSDNWMEARNFKE 367
            ||.:|.|.|||..:.||::.|::.: ||:..|..:.. |.|...|...::....|.|.|:
Worm   262 EESILGGISSGANVCAAVQLAKRPENKGKLIVTTVNSFGERYLSTALYAELRDNAANMKQ 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_001285508.1	cysta_beta	45..505	CDD:273464	117/320 (37%)
		CBS_like	54..352	CDD:107204	111/300 (37%)
		CBS_pair_PALP_assoc	386..504	CDD:239981
cysl-2	NP_497008.1	PLN02565	12..320	CDD:166206	116/317 (37%)
cysl-2	NP_497008.1	CBS_like	15..305	CDD:107204	111/299 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0031
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I2347
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54083
OrthoDB	1	1.010	-	-		D1016546at2759
OrthoFinder	1	1.000	-	-		FOG0000642
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100154
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.780