Protein Alignment Cbs and Cbs

DIOPT Version :10

• Sequence 1: NP_608424.1
• Gene: Cbs / 33081
• FlyBaseID: FBgn0031148
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_659104.1
• Gene: Cbs / 12411
• MGIID: 88285
• Length: 561
• Species: Mus musculus
• Alignment Length: 521
• Identity: 267/521 - (51%)
• Similarity: 350/521 - (67%)
• Gaps: 26/521 - (4%)

  Fly    13 FIDPGKPSKCKWHLGTA-EKSPHIHRGIAHRQQITPNILEVIGCTPLVKLNNIPASDGIECEMYA 76
            :|.|..||:|.|.||.| ..|||.|..:....:|.|:||..||.||:|::|.|..:.|::||:.|
Mouse    40 WIRPDTPSRCTWQLGRAMADSPHYHTVLTKSPKILPDILRKIGNTPMVRINKISKNAGLKCELLA 104

  Fly    77 KCEFLNPGGSVKDRIGYRMVQDAEEQGLLKPGYTIIEPTSGNTGIGLAMACAVKGYKCIIVMPEK 141
            ||||.|.||||||||..||::|||..|.||||.|||||||||||||||:|.|||||:||||||||
Mouse   105 KCEFFNAGGSVKDRISLRMIEDAERAGNLKPGDTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEK 169

  Fly   142 MSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETPNSIVLDQYRNAGNPLAHYDGTA 206
            ||.|||..||.|||:|:||||.|.:||||..:.||.:|:.|.|||.:|||||||.|||||||.||
Mouse   170 MSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDDTA 234

  Fly   207 AEILWQLDNKVDMIVVSAGTAGTISGIGRKIKEQVPSCQIVGVDPYGSILARPAELNKTDVQFYE 271
            .|||.|.|.|:||:|.||||.|||:||.||:||:.|.|:|:||||.|||||.|.|||:|:...||
Mouse   235 EEILQQCDGKLDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDPEGSILAEPEELNQTEQTAYE 299

  Fly   272 VEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNAEEGLLCGGSSGGAMHAALEHARKLKKG 336
            ||||||||.|||.|..|||.|.|..|.|.|..:|.|.|:||||||||||.||..|::.||:|::|
Mouse   300 VEGIGYDFIPTVLDRAVVDKWFKSNDEDSFAFARMLIAQEGLLCGGSSGSAMAVAVKAARELQEG 364

  Fly   337 QRCVVILPDGIRNYMTKFVSDNWMEARNF-KEPVNEHGHWWWSLAIAELELPAPPVILKSDATVG 400
            |||||||||.:||||:||:||.||..:.| ||.::....|||.|.:.||.|.||..:|.: .|..
Mouse   365 QRCVVILPDSVRNYMSKFLSDKWMLQKGFMKEELSVKRPWWWRLRVQELSLSAPLTVLPT-VTCE 428

  Fly   401 EAIALMKKHRVDQLPVVDQDDGSVLGVVGQETLITQIVSMNRQQSDPAIKALNKRVIRLNESEIL 465
            :.||::::...||.|||: :.|::||:|....:::.:::...:.||...|.|.|:...::.::.|
Mouse   429 DTIAILREKGFDQAPVVN-ESGAILGMVTLGNMLSSLLAGKVRPSDEVCKVLYKQFKPIHLTDTL 492

  Fly   466 GKLARVLEVDPSVLIL---------------------GKNPAGKVELK-ALATKLDVTTFIAAGK 508
            |.|:.:||:|...|::                     ....:.|.::. .:.|.:|:..|:||.:
Mouse   493 GTLSHILEMDHFALVVHEQIQSRDQAWSGVVGGPTDCSNGMSSKQQMVFGVVTAIDLLNFVAARE 557

  Fly   509 Q 509
            |
Mouse   558 Q 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cbs	NP_608424.1	cysta_beta	45..505	CDD:273464	251/482 (52%)
Cbs	NP_659104.1	cysta_beta	73..554	CDD:273464	253/487 (52%)