DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA4 and Hsp70Bbb

DIOPT Version :9

Sequence 1:NP_002145.3 Gene:HSPA4 / 3308 HGNCID:5237 Length:840 Species:Homo sapiens
Sequence 2:NP_788663.1 Gene:Hsp70Bbb / 50022 FlyBaseID:FBgn0051354 Length:641 Species:Drosophila melanogaster


Alignment Length:828 Identity:226/828 - (27%)
Similarity:361/828 - (43%) Gaps:205/828 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQ 65
            |..:|||||.....|.|.:.|.:|.|||:..:|.||:.::|....|.||..||:||..|.:|||.
  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65

Human    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130
            ..||..||.:.||.:..:..:..:.:|. ..|...|.|.|..|.:.|..|::::|:|:|:|||||
  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129

Human   131 SVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195
            :.|.:.:.|.|::||.::.|::|::..||..|||||.||::||.||.|||||:.|.    |::: 
  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN----LKDE- 189

Human   196 RNVVFVDMGHSAYQVSVCAFNRGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSK 259
            |||:..|:|...:.||:...:.|.| :|.:||.||.|||..||..||.|..|||.:|||.|::|.
  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSN 254

Human   260 IRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSV 324
            .|||.||....|:.|:.:| ::::..:.|:......|....::|.:|.|:|.||......|:...
  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318

Human   325 LEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PA 386
            |...|:.|..|:.:.:|||:||||.|:..:.:|| ||.|:.::|.||||..|.|:|.||||  .:
  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383

Human   387 FKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFYR---KEPFTLEAYYSS 448
            .|:::..:.||.|..:.:.     ..|....::..:|...|..:..||..   .:|......|..
  Fly   384 GKIQDVLLVDVAPLSLGIE-----TAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEG 443

Human   449 PQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETD 513
            .:.:...:.|:..|.:..:.|...| ..:::|...::.:||.:||                    
  Fly   444 ERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVS-------------------- 487

Human   514 QNAKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVD 578
                                            ::||.|.:|.:...|.|      |.::..:.:|
  Fly   488 --------------------------------AKEMSTGKAKNITIKND------KGRLSQAEID 514

Human   579 LPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSED 643
                         .|:|   |.| |...:|:..::|..::||:|.||:.::              
  Fly   515 -------------RMVN---EAE-KYADEDEKHRQRITSRNALESYVFNVK-------------- 548

Human   644 DRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKLFEELGKQIQQ 708
                                                          |..|:.|     .||    
  Fly   549 ----------------------------------------------QSVEQAP-----AGK---- 558

Human   709 YMKIISSFKNKEDQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIK 773
                             ||.||...|....||.:.|:::            :...:.:|.:.|::
  Fly   559 -----------------LDEADKNSVLDKCNETIRWLDS------------NTTAEKEEFDHKME 594

Human   774 ELTSTCSPIISKPKPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQG 821
            |||..||||::         |..|:.|   |...|.|.|.|.||...|
  Fly   595 ELTRHCSPIMT---------KMHQQGA---GAAGGPGANCGQQAGGFG 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA4NP_002145.3 HSPA4_NBD 2..384 CDD:212687 150/383 (39%)
HSP70 3..607 CDD:278441 185/610 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..575 7/74 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..840 15/43 (35%)
Hsp70BbbNP_788663.1 PTZ00009 2..641 CDD:240227 225/827 (27%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 150/382 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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