DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA4 and Hsc70-4

DIOPT Version :9

Sequence 1:	NP_002145.3	Gene:	HSPA4 / 3308	HGNCID:	5237	Length:	840	Species:	Homo sapiens
Sequence 2:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	691	Identity:	204/691 - (29%)
Similarity:	337/691 - (48%)	Gaps:	100/691 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     4 VGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQGFK 68
            ||||||.....|.|.:.|.:|.|||:..:|.||:.::|....|.||.|||:||..|...|:...|
  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAK 71

Human    69 RFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVL 133
            |..||.|.|..|:::..:..:::|. ..|...|:|||.:|::.|..|::::|:|:|:|||||:.|
  Fly    72 RLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135

Human   134 KKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNV 198
            .|.|.:.|::||.::.|::|::..||..|||||.||::||.||.|:|||:   |..|:.|  |||
  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGL---DKKAVGE--RNV 195

Human   199 VFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKIRAL 263
            :..|:|...:.||:.:.:.|..:|.:||.||.|||..||..||.||.:||.:|:|.|:.:..|||
  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260

Human   264 LRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSVLEQT 328
            .||...||:.|:.:| :::...:.|:......|...::.|.:|.|:..||......|:...|...
  Fly   261 RRLRTACERAKRTLS-SSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324

Human   329 KLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAIL--SPAFKVR 390
            ||.|..|:.:.:|||:||||.|:..:...| ||||:.::|.||||..|.|:|.|||  ..:.:|:
  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389

Human   391 EFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFYR---KEPFTLEAYYSSPQDL 452
            :..:.||.|..:.:.     ..|.....:..:|...|..:..||..   .:|..|...|...:.:
  Fly   390 DLLLLDVTPLSLGIE-----TAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAM 449

Human   453 PYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQN-- 515
            ...:..:.:|.:..:.|...| ..:::|...::.:||.:|::   :|...::||:..:..|:.
  Fly   450 TKDNNLLGKFELSGIPPAPRG-VPQIEVTFDIDANGILNVTA---LERSTNKENKITITNDKGRL 510

Human   516 AKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLP 580
            :||:.:..|::.|.:..|.::|
  Fly   511 SKEDIERMVNEAEKYRNEDEKQ------------------------------------------- 532

Human   581 IENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKF-VSEDD 644
                                           ||...|||.:|.|.:.|:..|..:..|. :|:.|
  Fly   533 -------------------------------KETIAAKNGLESYCFNMKATLDEDNLKTKISDSD 566

Human   645 RNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPI 685
            |.:...|..:|..|| :..:...|:.|..:..||:.:..||
  Fly   567 RTTILDKCNETIKWL-DANQLADKEEYEHRQKELEGVCNPI 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4	NP_002145.3	HSPA4_NBD	2..384	CDD:212687	152/382 (40%)
		HSP70	3..607	CDD:278441	181/610 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575		9/76 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..840
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	204/691 (30%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	151/380 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810