DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA4 and Hsc70-2

DIOPT Version :9

Sequence 1:	NP_002145.3	Gene:	HSPA4 / 3308	HGNCID:	5237	Length:	840	Species:	Homo sapiens
Sequence 2:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	690	Identity:	202/690 - (29%)
Similarity:	335/690 - (48%)	Gaps:	98/690 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     4 VGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQGFK 68
            :|||||.....|.|.:...:|.|||:..:|.||:.::|....|.||..||:||..||||||...|
  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAK 71

Human    69 RFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAESVL 133
            |..||.|.|..::.:.....:.::. ..|...|:|.:..|.:.|..|::::|:|:|::|.||..|
  Fly    72 RLIGRKFDDKKIQEDLKLWPFKVIN-EKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYL 135

Human   134 KKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNV 198
            ...|.|.||:||.::.|::|::..||..|||||.||::||.||.|||||:.|.     .:..|||
  Fly   136 GGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN-----LKGERNV 195

Human   199 VFVDMGHSAYQVSVCAFNRGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKIRA 262
            :..|:|...:.|||.:.:.|.| :|.|||.||.|||..||..|||||.|||.:|:|.|||...||
  Fly   196 LIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARA 260

Human   263 LLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSVLEQ 327
            |.||...||:.|:.:| ::::..|.|:.....:|....::|.:|.|:..||......|:...|..
  Fly   261 LRRLRTACERAKRTLS-SSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSD 324

Human   328 TKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PAFKV 389
            .|:.|:.|:.|.:|||:||||.:::.:...| ||:|:.::|.||||..|.|:|.|||:  .:.::
  Fly   325 AKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQI 389

Human   390 REFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPF--SKVLTFY--RKEPFTLEAYYSSPQ 450
            ::..:.||.|..:.:.     ..|.....:..:|...|.  .::.|.|  .:...|::. |...:
  Fly   390 QDLLLVDVAPLSLGIE-----TAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQV-YEGER 448

Human   451 DLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQN 515
            .:...:..:..|::..:.|...| ..:::|...:|..||.:|::                 .|.:
  Fly   449 AMTKDNNLLGTFNLTGIPPAPRG-VPQIEVAFDLNADGILNVNA-----------------KDNS 495

Human   516 AKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLP 580
            ..:.||:.:..::..:          :|||.:.|.:              :|:|.||
  Fly   496 TGKSEKITISNDKGRL----------SKAEIDRMLS--------------EAEKYKV-------- 528

Human   581 IENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDR 645
                                      :|..::||..:||.:|.|:|..|..:.......:||.:|
  Fly   529 --------------------------EDDRQRERVQSKNNLEAYIYACRQAVDDAPSGVLSETER 567

Human   646 NSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPI 685
            :....|.....:||.::...: |:.:...|.|.:.:..||
  Fly   568 SKVRDKCSSEASWLDKNSLAE-KEEFESHLKECQRICTPI 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4	NP_002145.3	HSPA4_NBD	2..384	CDD:212687	152/381 (40%)
		HSP70	3..607	CDD:278441	182/610 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575		11/74 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..840
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	202/690 (29%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	152/381 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810