Protein Alignment HSPA4 and Hsc70-1

DIOPT Version :10

• Sequence 1: NP_002145.3
• Gene: HSPA4 / 3308
• HGNCID: 5237
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 701
• Identity: 207/701 - (29%)
• Similarity: 337/701 - (48%)
• Gaps: 102/701 - (14%)

Human     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQ 65
            :..||||||.....|.|.:.|.:|.|||:..:|.||:.::|....|.||.|||:||..|..||:.
  Fly     4 LPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNNTIF 68

Human    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130
            ..||..||.|.|..|:::..:..:::. ...|...|:|.|..|.::|..|:|::|:|:|::||||
  Fly    69 DAKRLIGRRFDDATVQSDMKHWPFEVF-AENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRETAE 132

Human   131 SVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195
            :.|...|.|.||:||.::.|::|::..||..|||||.||::||.||.|:|||:.||.     ...
  Fly   133 AYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQG-----TSE 192

Human   196 RNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKI 260
            |||:..|:|...:.|||.....|..:|.|||.||.|||..||..|||||.:||.:|:|.|:....
  Fly   193 RNVLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNK 257

Human   261 RALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSVL 325
            |||.||...||:.|:.:| :::...:.|:.....||...::.|.:|.|:..||......|:...|
  Fly   258 RALRRLRTACERAKRTLS-SSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKAL 321

Human   326 EQTKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAIL--SPAF 387
            ...|:.|..|:.:.:|||:||||.|:..:..|| ||||:.::|.||||..|.|:|.|||  ..:.
  Fly   322 RDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSE 386

Human   388 KVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPF--SKVLTFYR-KEPFTLEAYYSSP 449
            .|::..:.||.|..:.:.     ..|.....:..:|...|.  :::.|.|. .:|..|...:...
  Fly   387 AVQDLLLLDVTPLSLGIE-----TAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGE 446

Human   450 QDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQ 514
            :.:...:.::.:|.:..:.|...| ..:|:|...::.:||.:|::   :|....:||...:..|:
  Fly   447 RAMTRDNNSLGKFELSAIPPAPRG-VPQVEVTFDIDANGILNVTA---LEKSTGKENRITITNDK 507

Human   515 N--AKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTV 577
            .  :||:.:..|:..|.:.:..:||
  Fly   508 GRLSKEDIERMVNDAEAYRQADEQQ---------------------------------------- 532

Human   578 DLPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEY--EKFV 640
                                              ::|.:|||.:|.|.:::|..|..|:  .:|
  Fly   533 ----------------------------------RDRINAKNQLESYCFQLRSTLDDEHLSSRF- 562

Human   641 SEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKIRFQE 691
            |..||.:...:..:|..|| :..:...:|.:..|..||:.:..||..|..:
  Fly   563 SPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQELERICSPIITRLYQ 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4	NP_002145.3	ASKHA_NBD_HSP70_HSPA4	2..382	CDD:466843	152/380 (40%)
		PTZ00121	<499..743	CDD:173412	33/197 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..575		9/76 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	779..840
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	207/701 (30%)