DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA4 and CG7182

DIOPT Version :9

Sequence 1:	NP_002145.3	Gene:	HSPA4 / 3308	HGNCID:	5237	Length:	840	Species:	Homo sapiens
Sequence 2:	NP_001286979.1	Gene:	CG7182 / 38944	FlyBaseID:	FBgn0035878	Length:	513	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	120/521 - (23%)
Similarity:	210/521 - (40%)	Gaps:	74/521 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     5 GIDLGFQSCYVAVARAGG-IETIANEYSDRCTPACISF-GPKNRSIGAAAKSQVISNAKNTVQGF 67
            ||.:|..:..:|..||.| .|.|||:..||.:.||:.: |......|..||.::.:..:..|.
  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVA-- 68

Human    68 KRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEE---------------RNFTTEQV 117
               |......|..|..:..|:..:.::|......::.:..|.               ::.:..||
  Fly    69 ---HSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDREDQDDRVVTKDLSAYQV 130

Human   118 TAMLLSKLKETAESV----LKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVA 178
            |..||....|.|...    .:.|:  .|:|:|.:|..:..:.:.||.|.||.:..:::.|.||..
  Fly   131 TVELLRAELELAHQYHTDGEQAPI--AVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAV 193

Human   179 LAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNH 243
            |.|.|.::.    .|:.|:|:.:..|.....::..:...|....|||.....:|||:|.|.||..
  Fly   194 LGYSIGEEQ----TEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQF 254

Human   244 FCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLE 308
            .||||.:|||||.....|::.::.......|.:::...| ..|.|:..|:.||.:..|:|.:|..
  Fly   255 ICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPS-TQLYIDSLMDGVDYNAQMSRARFES 318

Human   309 MCNDLLARVEPPLRSVLEQTKLKKEDIYAVE---IVGGATRIPAVKEKI-SKFFGKELSTTLNAD 369
            :...::..:...|...:||.:.:...:..::   ::|...:||.::..: ::|...:|..:.:||
  Fly   319 LIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSAD 383

Human   370 EAVTRGCALQCAILSPAFKVREFSITDVV-------------------------PYPISLRWNSP 409
            |.|..|||.|...|....:.:.....|.|                         ..|..:|.:.|
  Fly   384 EVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLGRGSVLPAKIRISLP 448

Human   410 -AEEGSSDCEVFSKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDG 473
             :|||..|          ..||....::......|.....| |...|:..:.|..|:......||
  Fly   449 QSEEGKGD----------DVSKAAASFKLRTGESEILARLP-DSTIPEDGLYQLEVEVDVDDKDG 502

Human   474 S 474
            :
  Fly   503 N 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4	NP_002145.3	HSPA4_NBD	2..384	CDD:212687	100/403 (25%)
		HSP70	3..607	CDD:278441	120/521 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..840
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	99/399 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900