Protein Alignment HSPA4 and CG7182

DIOPT Version :10

• Sequence 1: NP_002145.3
• Gene: HSPA4 / 3308
• HGNCID: 5237
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_648212.1
• Gene: CG7182 / 38944
• FlyBaseID: FBgn0035878
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 120/521 - (23%)
• Similarity: 210/521 - (40%)
• Gaps: 74/521 - (14%)

Human     5 GIDLGFQSCYVAVARAGG-IETIANEYSDRCTPACISF-GPKNRSIGAAAKSQVISNAKNTVQGF 67
            ||.:|..:..:|..||.| .|.|||:..||.:.||:.: |......|..||.::.:..:..|.
  Fly     6 GIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAVA-- 68

Human    68 KRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEE---------------RNFTTEQV 117
               |......|..|..:..|:..:.::|......::.:..|.               ::.:..||
  Fly    69 ---HSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRMEHTVPSDREDQDDRVVTKDLSAYQV 130

Human   118 TAMLLSKLKETAESV----LKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVA 178
            |..||....|.|...    .:.|:  .|:|:|.:|..:..:.:.||.|.||.:..:::.|.||..
  Fly   131 TVELLRAELELAHQYHTDGEQAPI--AVLSIPSYYPASAYKLLADAAQTAGFHVAQIITEPTAAV 193

Human   179 LAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNH 243
            |.|.|.::.    .|:.|:|:.:..|.....::..:...|....|||.....:|||:|.|.||..
  Fly   194 LGYSIGEEQ----TEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGRQFTEALVQF 254

Human   244 FCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLE 308
            .||||.:|||||.....|::.::.......|.:::...| ..|.|:..|:.||.:..|:|.:|..
  Fly   255 ICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPS-TQLYIDSLMDGVDYNAQMSRARFES 318

Human   309 MCNDLLARVEPPLRSVLEQTKLKKEDIYAVE---IVGGATRIPAVKEKI-SKFFGKELSTTLNAD 369
            :...::..:...|...:||.:.:...:..::   ::|...:||.::..: ::|...:|..:.:||
  Fly   319 LIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAKLHNSHSAD 383

Human   370 EAVTRGCALQCAILSPAFKVREFSITDVV-------------------------PYPISLRWNSP 409
            |.|..|||.|...|....:.:.....|.|                         ..|..:|.:.|
  Fly   384 EVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWHGNDESNAKLVLGRGSVLPAKIRISLP 448

Human   410 -AEEGSSDCEVFSKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDG 473
             :|||..|          ..||....::......|.....| |...|:..:.|..|:......||
  Fly   449 QSEEGKGD----------DVSKAAASFKLRTGESEILARLP-DSTIPEDGLYQLEVEVDVDDKDG 502

Human   474 S 474
            :
  Fly   503 N 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4	NP_002145.3	ASKHA_NBD_HSP70_HSPA4	2..382	CDD:466843	100/401 (25%)
		PTZ00121	<499..743	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	779..840
CG7182	NP_648212.1	ASKHA_ATPase-like	5..394	CDD:483947	99/399 (25%)