DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA4 and Hsc70-5

DIOPT Version :9

Sequence 1:	NP_002145.3	Gene:	HSPA4 / 3308	HGNCID:	5237	Length:	840	Species:	Homo sapiens
Sequence 2:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	651	Identity:	185/651 - (28%)
Similarity:	298/651 - (45%)	Gaps:	104/651 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     2 SVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPK-NRSIGAAAKSQVISNAKNTVQ 65
            :|:|||||..:..:||......:.|.|....|.||:.::|... .|.:|..||.|.::|:.||..
  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117

Human    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130
            ..||..||.|.||.|:.:.:||:|.:|:...|...:..|   :.:.::..|:.|.:|.|:|||||
  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSST---DGKVYSPSQIGAFILMKMKETAE 179

Human   131 SVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195
            :.|..||.:.||:||.::.|::|::..||.||||||.||::||.||.|||||:.|.:       .
  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-------D 237

Human   196 RNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKI 260
            :.:...|:|...:.:|:....:|..:|.:|..||.|||..||..:||....||.|...:||:...
  Fly   238 KIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDN 302

Human   261 RALLRLSQECEKLK-KLMSANASDLPLSIECFMNDVDVSG------TMNRGKFLEMCNDLLARVE 318
            .|:.||.:..||.| :|.|:..:|:.|.   ::. :|.:|      .:.|.|...:..||:.|..
  Fly   303 IAMQRLKEAAEKAKCELSSSQQTDINLP---YLT-MDAAGPQHMNLKLTRSKLESLVGDLIKRTI 363

Human   319 PPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAIL 383
            .|.:..|...::.|.:|..|.:|||.||:|.|:..:.:.||::.|.::|.||||..|.|:|..:|
  Fly   364 QPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVL 428

Human   384 SPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTF-------------- 434
              |..|.:..:.||.|..:.:.     ..|.....:.|:|...|..|...|
  Fly   429 --AGDVTDVLLLDVTPLSLGIE-----TLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKV 486

Human   435 YRKE-----------PFTLEAYYSSPQDLPYPD-------PAIAQFSV--------QKVTPQSDG 473
            ::.|           .|||.....:|:.:|..:       ..|...|.        |::..||.|
  Fly   487 HQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQSSG 551

Human   474 SSSKVKVK---VRVNVHGIFSVSSASLVE--------VHKSEENEEPMETDQNAKEEEKMQ---- 523
            ..||.:::   .:...:.........|:|        ||.:|...|..::...|:|.||::
  Fly   552 GLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIA 616

Human   524 ------VDQEEPHVEEQQQQTP------------AENKAESEEMETSQAGSKD--KKMDQPPQAK 568
                  .::|...:||.::.|.            |..|..:|....:.|||.|  ...|...:||
  Fly   617 DLRTLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAK 681

Human   569 K 569
            |
  Fly   682 K 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4	NP_002145.3	HSPA4_NBD	2..384	CDD:212687	134/389 (34%)
		HSP70	3..607	CDD:278441	185/650 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575		23/94 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..840
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	177/633 (28%)
		HSPA9-like_NBD	51..428	CDD:212683	134/388 (35%)
		Syntaphilin	<566..>642	CDD:291936	14/75 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900