Protein Alignment HSPA4 and Hsc70-3

DIOPT Version :9

• Sequence 1: NP_002145.3
• Gene: HSPA4 / 3308
• HGNCID: 5237
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_001285139.1
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Alignment Length: 706
• Identity: 204/706 - (28%)
• Similarity: 341/706 - (48%)
• Gaps: 127/706 - (17%)

Human     2 SVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISF-GPKNRSIGAAAKSQVISNAKNTVQ 65
            :|:|||||.....|.|.:.|.:|.|||:..:|.||:.::| ....|.||.|||:|:.:|.:|||.
  Fly    30 TVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTVF 94

Human    66 GFKRFHGRAFSD----------PFVEAEKS---NLAYDIVQLPTGLTGIKVTYMEEERNFTTEQV 117
            ..||..||.:||          ||...||:   :::.|..|      |.||        |..|::
  Fly    95 DAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQ------GAKV--------FAPEEI 145

Human   118 TAMLLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYG 182
            :||:|.|:|||||:.|.|.|...||:||.::.||:|::..||..||||..:|::||.||.|:|||
  Fly   146 SAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYG 210

Human   183 IYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEE 247
            :.|      :|..:||:..|:|...:.||:...:.|..:|:||..||.|||..||:.:::||.:.
  Fly   211 LDK------KEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKL 269

Human   248 FGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCND 312
            :.||...||:...||:.:|.:|.||.|:.:| .:..:.:.||.|....|.|.|:.|.||.|:..|
  Fly   270 YKKKKGKDIRKDNRAVQKLRREVEKAKRALS-GSHQVRIEIESFFEGDDFSETLTRAKFEELNLD 333

Human   313 LLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGC 376
            |......|::.|||...:.|:|::.:.:|||:||||.|::.:..|| |||.|..:|.||||..|.
  Fly   334 LFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGA 398

Human   377 ALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFY----RK 437
            |:|..:||.........:.||.|..:.:.     ..|....::..:|...|..|...|.    .:
  Fly   399 AVQAGVLSGEQDTDAIVLLDVNPLTMGIE-----TVGGVMTKLIPRNTVIPTKKSQVFSTASDNQ 458

Human   438 EPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHK 502
            ...|::. |...:.:...:..:.:|.:..:.|...| ..:::|...::.:||..||:
  Fly   459 HTVTIQV-YEGERPMTKDNHLLGKFDLTGIPPAPRG-IPQIEVSFEIDANGILQVSA-------- 513

Human   503 SEENEEPMETDQNAKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQA 567
                     .|:....:||:.:      ..:|.:.||.:
  Fly   514 ---------EDKGTGNKEKIVI------TNDQNRLTPED-------------------------- 537

Human   568 KKAKVKTSTVDLPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKL 632
                                 |||     .|.:..|...:||..|||.:::|.:|.|.|.:::::
  Fly   538 ---------------------IDR-----MIRDAEKFADEDKKLKERVESRNELESYAYSLKNQI 576

Human   633 SGEYEKF---VSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPI 685
             |:.:|.   :|:|::|.....::::..||.::.:..|:: |..:..:|:.:.||:
  Fly   577 -GDKDKLGAKLSDDEKNKLESAIDESIKWLEQNPDADPEE-YKKQKKDLEAIVQPV 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA4	NP_002145.3	HSPA4_NBD	2..384	CDD:212687	152/396 (38%)
		HSP70	3..607	CDD:278441	183/622 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..575		6/74 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	779..840
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	152/393 (39%)
		PTZ00009	32..643	CDD:240227	203/704 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810