DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1529 and Zfp808

DIOPT Version :9

Sequence 1:	NP_001138223.2	Gene:	CG1529 / 33077	FlyBaseID:	FBgn0031144	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001034328.2	Gene:	Zfp808 / 630579	MGIID:	3704127	Length:	753	Species:	Mus musculus

Alignment Length:	509	Identity:	125/509 - (24%)
Similarity:	184/509 - (36%)	Gaps:	115/509 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DILKQPHGFPTEI----------CNLCHNAVVYFDELRQVARESSQKLIGWQPVDIAVDRVKEEP 96
            ::....|...|.|          ||||..:....:.|:...|..:    |.:|       .|.:.
Mouse   168 EVFSFKHHLQTHIRVHTGEKPFKCNLCDKSFSKHNHLQSHRRTHT----GEKP-------YKCDQ 221

  Fly    97 PDEGLKENHEENEHELEEEHEKQADGQQVD--LSKKQEDQKKILDDREDEEYP--------DEYE 151
            .|:...|......|......||.....|.|  .|:|...||.|.....::.|.        .:|.
Mouse   222 CDKAFSEKCNLQTHIRIHTGEKPYKCDQCDKTFSEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYS 286

  Fly   152 NSQQQLSQGTGSKRRAGLACDQCGKQVYKLPYLEAHIRSVHQGYSKPFLCRSCDKSFTRYEQLRS 216
            ..|......||.|   ...|:||.|...:...|:.| |..|.| .|||.|..|||:|::|..|::
Mouse   287 TLQTHRRTHTGEK---PYKCNQCDKAFSQYGNLQTH-RRTHTG-EKPFKCNQCDKAFSQYSTLQT 346

  Fly   217 HMR--------------NAHPQLEQLQQELR------DLICELCNRQYSTKNALGEHLKRHAQRK 261
            |.|              .|..:...||:.:|      ...|..||:.:|....|..|.:.|...|
Mouse   347 HRRTHTGEKPYKCNQCDKAFSEKCSLQRHIRIHTGEKPYKCNQCNKAFSHNYHLHIHRRTHTGEK 411

  Fly   262 EHVCEHCGVAKVTRTELLTHLRTHNPTWER-FKCEQCPQLFRHKSAISRHVRVVHEGQRRFQCGH 325
            .:.|..|..|......|..|.|||  |.|: :||.||.:.|..|..:..|:| :|.|::.::|..
Mouse   412 PYKCNQCDKAFSIHFPLQNHKRTH--TGEKPYKCNQCDKAFSEKCHLQNHIR-IHTGEKPYKCNQ 473

  Fly   326 CEKKFGTHASQVRHERLHTESTGSGEAAEEWPFACIHCQKPCVSRQTLELHLRRHRARKTHR--- 387
            |:|.|..:.|...|.|:||     ||.    ||.|..|.|......||:.|.|.|...|..:
Mouse   474 CDKAFSQYFSLQTHRRIHT-----GEK----PFKCNQCDKAFSQYSTLQTHRRTHTGEKPFKCNQ 529

  Fly   388 -------------KRREHSRE------------SQEQEQEHDRDQEQGAREAQQDQLRKGEKLRQ 427
                         .||.||.|            ||....:..|....|.:..:.||.   :|...
Mouse   530 CDKAFSKHSTLQSHRRTHSGEKPFKCSQCDKAFSQYNTLQAHRRTHSGEKPFKCDQC---DKAFS 591

  Fly   428 RDLSRESHRNEVTMQTSQRPNECQQGQESYD------------PEPDPLEASQC 469
            ...:.:.|   :.:.|.::|.:|.|..:::.            ....|.:.:||
Mouse   592 EKCNLQKH---IRIHTGEKPYKCNQCDKAFSQYNTLQTHRRIHTGEKPFKCNQC 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1529	NP_001138223.2	zf-AD	11..79	CDD:285071	9/46 (20%)
		C2H2 Zn finger	171..192	CDD:275368	7/20 (35%)
		zf-C2H2_2	201..>257	CDD:289522	19/75 (25%)
		C2H2 Zn finger	201..222	CDD:275368	9/34 (26%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	265..285	CDD:275368	6/19 (32%)
		zf-C2H2_8	268..349	CDD:292531	28/81 (35%)
		C2H2 Zn finger	294..315	CDD:275368	7/20 (35%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
Zfp808	NP_001034328.2	KRAB	4..>45	CDD:214630
		KRAB	4..40	CDD:279668
		COG5048	<130..284	CDD:227381	25/126 (20%)
		C2H2 Zn finger	135..155	CDD:275368
		C2H2 Zn finger	163..183	CDD:275368	3/14 (21%)
		zf-H2C2_2	175..199	CDD:290200	6/23 (26%)
		C2H2 Zn finger	191..211	CDD:275368	6/19 (32%)
		zf-H2C2_2	203..227	CDD:290200	6/34 (18%)
		C2H2 Zn finger	219..239	CDD:275368	3/19 (16%)
		zf-H2C2_2	231..255	CDD:290200	5/23 (22%)
		C2H2 Zn finger	247..267	CDD:275368	7/19 (37%)
		zf-H2C2_2	259..284	CDD:290200	4/24 (17%)
		C2H2 Zn finger	275..295	CDD:275368	2/19 (11%)
		zf-H2C2_2	288..312	CDD:290200	8/26 (31%)
		C2H2 Zn finger	303..323	CDD:275368	7/20 (35%)
		zf-H2C2_2	315..340	CDD:290200	13/26 (50%)
		COG5048	327..728	CDD:227381	86/334 (26%)
		C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		zf-H2C2_2	344..367	CDD:290200	4/22 (18%)
		C2H2 Zn finger	359..379	CDD:275368	4/19 (21%)
		zf-H2C2_2	371..396	CDD:290200	6/24 (25%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	11/24 (46%)
		C2H2 Zn finger	443..463	CDD:275368	7/20 (35%)
		zf-H2C2_2	455..480	CDD:290200	8/25 (32%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	483..508	CDD:290200	12/33 (36%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		zf-H2C2_2	512..535	CDD:290200	5/22 (23%)
		C2H2 Zn finger	527..547	CDD:275368	2/19 (11%)
		zf-H2C2_2	540..564	CDD:290200	5/23 (22%)
		C2H2 Zn finger	555..575	CDD:275368	3/19 (16%)
		zf-H2C2_2	568..591	CDD:290200	5/25 (20%)
		C2H2 Zn finger	583..603	CDD:275368	4/25 (16%)
		zf-H2C2_2	595..620	CDD:290200	5/27 (19%)
		C2H2 Zn finger	611..631	CDD:275368	2/19 (11%)
		zf-H2C2_2	624..648	CDD:290200	3/19 (16%)
		C2H2 Zn finger	639..659	CDD:275368	2/4 (50%)
		zf-H2C2_2	652..676	CDD:290200
		C2H2 Zn finger	667..687	CDD:275368
		zf-H2C2_2	679..703	CDD:290200
		C2H2 Zn finger	695..715	CDD:275368
		zf-H2C2_2	707..730	CDD:290200
		C2H2 Zn finger	723..743	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000