DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1529 and Zfp189

DIOPT Version :9

Sequence 1:	NP_001138223.2	Gene:	CG1529 / 33077	FlyBaseID:	FBgn0031144	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001101400.1	Gene:	Zfp189 / 313219	RGDID:	1306510	Length:	608	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	125/540 - (23%)
Similarity:	206/540 - (38%)	Gaps:	154/540 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DIAVDRVKEEPPDEGLKENHEENEHELEEEHEKQADGQQVDLS--KKQEDQKKI------LDDRE 142
            |:.:|...:....:.|..| |:.|..::||.||..:.|.:.::  |.:.||..:      |..|.
  Rat    27 DVVMDSYGKLVSLDVLNRN-EDEEPTVKEEIEKDIEPQGIIVTRIKSELDQDPMGSETFELVGRL 90

  Fly   143 DE-------EYPDEYENSQQQLSQG-TGSKRRAGL-----ACDQCGKQVYKLPYLEAHIRSVHQG 194
            |:       |.|.:....:|::.:| |..::|...     .|::|||:..:..:...|.| ||.|
  Rat    91 DKQRGIFLWEIPRDSLTEEQKMFRGHTNVRKRPNSEEKCHKCEECGKRFVRKAHFIQHQR-VHTG 154

  Fly   195 YSKPFLCRSCDKSFTRYEQLRSHMR---NAHP-----------------QLEQLQQELRDLICEL 239
             .|||.|..|.|||:|...:..|.|   ...|                 :.:::....|...|..
  Rat   155 -EKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQ 218

  Fly   240 CNRQYSTKNALGEHLKRHAQRKEHVCEHCGVAKVTRTELLTHLRTHNPTWER-FKCEQCPQLFRH 303
            |.:.:|.:.:|.:|.:.|...|.|.|..||.|...::.|:.|.|||  |.|: :.|.:|.:.|..
  Rat   219 CKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTH--TGEKPYHCTKCKKSFSR 281

  Fly   304 KSAISRHVRVVHEGQRRFQCGHCEKKFGTHASQVRHERLHTESTGSGEAAEEWPFACIHCQKPCV 368
            .|.:..|.| :|.|:|..:||.|.|.|......::|:::||     ||.    ||.||.|.| ..
  Rat   282 NSLLVEHQR-IHTGERPHKCGECGKAFRLSTYLIQHQKIHT-----GEK----PFLCIECGK-SF 335

  Fly   369 SRQT-----------------------------LELHLRRHRARKTHR----------------K 388
            ||.:                             |..|.|.|...|.|:                .
  Rat   336 SRSSFLIEHQRIHTGERPYQCQECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQH 400

  Fly   389 RREHSRESQE-----------------QEQEHDRDQEQ-----------GAREAQQDQLRKGEK- 424
            :|.|.||...                 |::.:.:::..           .|...|..::..|||
  Rat   401 QRIHIREKTSPFKETKGSFDPNCGLVIQQEVYPKEKSYKCDDCGKTFSVSAHLVQHQRIHTGEKP 465

  Fly   425 ----LRQRDLSRES----HRNEVTMQTSQRPNECQQGQESYDPEPDPLEASQCKLEQEDALDP-E 480
                :..:..||.|    |:.   :.|.:||..|:|..:|:        :..|.|.:...:.. .
  Rat   466 YLCTVCGKSFSRSSFLIEHQR---IHTGERPYLCRQCGKSF--------SQLCNLIRHQGVHTGN 519

  Fly   481 WQHKIEQ--DAESQDSARLE 498
            ..||.|:  .|.|::|..::
  Rat   520 KPHKCEECGKAFSRNSGLIQ 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1529	NP_001138223.2	zf-AD	11..79	CDD:285071
		C2H2 Zn finger	171..192	CDD:275368	6/20 (30%)
		zf-C2H2_2	201..>257	CDD:289522	15/75 (20%)
		C2H2 Zn finger	201..222	CDD:275368	8/23 (35%)
		C2H2 Zn finger	237..257	CDD:275368	5/19 (26%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		zf-C2H2_8	268..349	CDD:292531	27/81 (33%)
		C2H2 Zn finger	294..315	CDD:275368	6/20 (30%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	9/48 (19%)
Zfp189	NP_001101400.1	KRAB_A-box	<10..39	CDD:143639	2/11 (18%)
		COG5048	116..506	CDD:227381	96/415 (23%)
		C2H2 Zn finger	132..152	CDD:275368	6/20 (30%)
		zf-H2C2_2	144..169	CDD:290200	13/26 (50%)
		C2H2 Zn finger	160..180	CDD:275368	8/19 (42%)
		zf-H2C2_2	175..196	CDD:290200	3/20 (15%)
		C2H2 Zn finger	188..208	CDD:275368	0/19 (0%)
		zf-H2C2_2	201..225	CDD:290200	3/23 (13%)
		C2H2 Zn finger	216..236	CDD:275368	5/19 (26%)
		zf-H2C2_2	228..252	CDD:290200	9/23 (39%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		zf-H2C2_2	256..281	CDD:290200	10/26 (38%)
		C2H2 Zn finger	272..292	CDD:275368	6/20 (30%)
		zf-H2C2_2	285..307	CDD:290200	9/22 (41%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		zf-H2C2_2	312..337	CDD:290200	11/34 (32%)
		C2H2 Zn finger	328..348	CDD:275368	6/20 (30%)
		zf-H2C2_2	341..365	CDD:290200	0/23 (0%)
		C2H2 Zn finger	356..376	CDD:275368	3/19 (16%)
		zf-H2C2_2	368..393	CDD:290200	6/24 (25%)
		C2H2 Zn finger	384..404	CDD:275368	1/19 (5%)
		C2H2 Zn finger	440..460	CDD:275368	2/19 (11%)
		zf-H2C2_2	452..477	CDD:290200	4/24 (17%)
		C2H2 Zn finger	468..488	CDD:275368	4/22 (18%)
		zf-H2C2_2	481..505	CDD:290200	7/34 (21%)
		C2H2 Zn finger	496..516	CDD:275368	5/27 (19%)
		zf-H2C2_2	508..533	CDD:290200	5/24 (21%)
		C2H2 Zn finger	524..544	CDD:275368	4/16 (25%)
		zf-H2C2_2	537..561	CDD:290200	0/3 (0%)
		C2H2 Zn finger	552..572	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000