DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1529 and Zfp189

DIOPT Version :9

Sequence 1:	NP_001138223.2	Gene:	CG1529 / 33077	FlyBaseID:	FBgn0031144	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001276830.1	Gene:	Zfp189 / 230162	MGIID:	2444707	Length:	608	Species:	Mus musculus

Alignment Length:	487	Identity:	129/487 - (26%)
Similarity:	203/487 - (41%)	Gaps:	111/487 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RQVARESSQKLIGWQPVDIAVDRVKEEPPDEGLKENHEENEHELEEEHEKQADGQQVDLSKKQED 133
            :.|..:|..||:.   :|: ::|.|:|.|.  :||       |||::.|.|  |..|...|.:.|
Mouse    26 KDVMMDSYGKLVS---LDV-LNRNKDEEPT--VKE-------ELEKDIEPQ--GVIVTRIKSEID 75

  Fly   134 QKKI------LDDREDE-------EYPDEYENSQQQLSQGTGSKRRAGLA------CDQCGKQVY 179
            |..:      |..|.|:       |.|.:..:.:|:|.:|..:.|:...:      |::|||:..
Mouse    76 QDPVGSETFELVGRLDKQRGIFLWEIPRDSLSEEQKLFRGHTNVRKRPTSEEKCHKCEECGKRFV 140

  Fly   180 KLPYLEAHIRSVHQGYSKPFLCRSCDKSFTRYEQLRSHMR---NAHP-----------------Q 224
            :..:...|.| ||.| .|||.|..|.|||:|...:..|.|   ...|                 :
Mouse   141 RKAHFIQHQR-VHTG-EKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIR 203

  Fly   225 LEQLQQELRDLICELCNRQYSTKNALGEHLKRHAQRKEHVCEHCGVAKVTRTELLTHLRTHNPTW 289
            .:::....|...|..|.:.:|.:.:|.:|.:.|...|.|.|..||.|...::.|:.|.|||  |.
Mouse   204 HQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTH--TG 266

  Fly   290 ER-FKCEQCPQLFRHKSAISRHVRVVHEGQRRFQCGHCEKKFGTHASQVRHERLHTESTGSGEAA 353
            |: :.|.:|.:.|...|.:..|.| :|.|:|..:||.|.|.|......::|:::||     ||.
Mouse   267 EKPYHCTKCKKSFSRNSLLVEHQR-IHTGERPHKCGECGKAFRLSTYLIQHQKIHT-----GEK- 324

  Fly   354 EEWPFACIHCQKPCVSRQTLELHLRRHRARKTHRKRREHSRESQEQEQEHDRDQEQGAREAQQDQ 418
               ||.||.|.| ..||.:.   |..|        :|.|:.|...|.||..:...|.....:..:
Mouse   325 ---PFLCIECGK-SFSRSSF---LIEH--------QRIHTGERPYQCQECGKSFSQLCNLTRHQR 374

  Fly   419 LRKGEKLRQ-----RDLSRES--------HRNEVTMQTSQRPNECQQGQESYDPEPDPLEASQCK 470
            :..|:|..:     :..||.|        |..|.|...|:.       :||:||        .|.
Mouse   375 IHTGDKPHKCEECGKAFSRSSGLIQHQRIHIREKTSPFSET-------KESFDP--------NCS 424

  Fly   471 LEQEDALDP-EWQHKIEQDAES-QDSARLEGH 500
            |..:..:.| |..:|.:...:: ..||.|..|
Mouse   425 LVIQQEVSPKEKSYKCDDCGKTFSVSAHLVQH 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1529	NP_001138223.2	zf-AD	11..79	CDD:285071	2/9 (22%)
		C2H2 Zn finger	171..192	CDD:275368	6/20 (30%)
		zf-C2H2_2	201..>257	CDD:289522	15/75 (20%)
		C2H2 Zn finger	201..222	CDD:275368	8/23 (35%)
		C2H2 Zn finger	237..257	CDD:275368	5/19 (26%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		zf-C2H2_8	268..349	CDD:292531	27/81 (33%)
		C2H2 Zn finger	294..315	CDD:275368	6/20 (30%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
Zfp189	NP_001276830.1	KRAB_A-box	<12..39	CDD:143639	4/15 (27%)
		COG5048	116..506	CDD:227381	100/382 (26%)
		C2H2 Zn finger	132..152	CDD:275368	6/20 (30%)
		zf-H2C2_2	144..169	CDD:290200	13/26 (50%)
		C2H2 Zn finger	160..180	CDD:275368	8/19 (42%)
		zf-H2C2_2	175..196	CDD:290200	3/20 (15%)
		C2H2 Zn finger	188..208	CDD:275368	0/19 (0%)
		zf-H2C2_2	201..225	CDD:290200	3/23 (13%)
		C2H2 Zn finger	216..236	CDD:275368	5/19 (26%)
		zf-H2C2_2	228..252	CDD:290200	9/23 (39%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		zf-H2C2_2	256..281	CDD:290200	10/26 (38%)
		C2H2 Zn finger	272..292	CDD:275368	6/20 (30%)
		zf-H2C2_2	285..307	CDD:290200	9/22 (41%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		zf-H2C2_2	312..337	CDD:290200	11/34 (32%)
		C2H2 Zn finger	328..348	CDD:275368	9/31 (29%)
		zf-H2C2_2	341..365	CDD:290200	8/31 (26%)
		C2H2 Zn finger	356..376	CDD:275368	3/19 (16%)
		zf-H2C2_2	368..393	CDD:290200	2/24 (8%)
		C2H2 Zn finger	384..404	CDD:275368	3/19 (16%)
		C2H2 Zn finger	440..460	CDD:275368	4/17 (24%)
		zf-H2C2_2	452..477	CDD:290200	2/5 (40%)
		C2H2 Zn finger	468..488	CDD:275368
		zf-H2C2_2	481..505	CDD:290200
		C2H2 Zn finger	496..516	CDD:275368
		zf-H2C2_2	508..533	CDD:290200
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	537..561	CDD:290200
		C2H2 Zn finger	552..572	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000