DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1529 and ZNF560

DIOPT Version :9

Sequence 1:	NP_001138223.2	Gene:	CG1529 / 33077	FlyBaseID:	FBgn0031144	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_689689.2	Gene:	ZNF560 / 147741	HGNCID:	26484	Length:	790	Species:	Homo sapiens

Alignment Length:	348	Identity:	98/348 - (28%)
Similarity:	148/348 - (42%)	Gaps:	55/348 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 EDEEYPDEYENSQ---QQLSQGTGSKRRAGLACDQCGKQVYKLPYLEAHIRSVHQGYSKPFLCRS 203
            |.:||...:..|.   :.....||.||   ..||||||.......|.||:|: |.| .|||.|..
Human   461 EHKEYGKAFGTSSGVIEDRRSNTGQKR---FDCDQCGKVFVSFSSLFAHLRT-HTG-EKPFKCYK 520

  Fly   204 CDKSFTRYEQLRSHMRNAHPQLEQLQQELRDLICELCNRQYSTKNALGEHLKRHAQRKEHVCEHC 268
            |.|.||....||.||| .|.: |:|.|      |:.|.:.::..:.|.:||:.||..|.:.|..|
Human   521 CGKPFTSSACLRIHMR-THTE-ERLYQ------CKKCGKAFTKCSYLTKHLRTHAGEKPYECMKC 577

  Fly   269 GVAKVTRTELLTHLRTHNPTWERFKCEQCPQLFRHKSAISRHVRVVHEGQRRFQCGHCEKKFGTH 333
            |.|...|:.|..|||.|:.. :.::|::|.:.|..:|.:::|:| .|.|.:.::...|.|.|...
Human   578 GKAFTERSYLTKHLRRHSGE-KPYECKKCGKAFTERSDLTKHLR-RHTGDKPYEYKDCGKAFVVS 640

  Fly   334 ASQVRHERLHTESTGSGEAAEEWPFACIHCQKPCVSRQTLELHLRRHRARKTHRKRREHSRESQE 398
            :|.|.|.|.||...         |:.|..|:|.......|..||:.|.|.|| .:........:.
Human   641 SSLVDHLRTHTGYK---------PYKCNACEKAYSRSCVLTQHLKTHAAEKT-SECNACGNSFRN 695

  Fly   399 QEQEHDRDQEQGAREAQQDQLRKGEKLRQRDLSR-----ESHRNEVTMQTSQRPNECQQGQESYD 458
            ....|||          ...|.|.:..:.:|..:     ....|.|.:.|.::|.:|::..:::.
Human   696 SMCFHDR----------LKTLTKIKPYKCKDCGKAFTCHSDLTNHVRIHTGEKPYKCKECGKAFR 750

  Fly   459 PE------------PDPLEASQC 469
            ..            ..|.|..||
Human   751 TSSGRIQHLRTHMGEKPFECDQC 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1529	NP_001138223.2	zf-AD	11..79	CDD:285071
		C2H2 Zn finger	171..192	CDD:275368	10/20 (50%)
		zf-C2H2_2	201..>257	CDD:289522	19/55 (35%)
		C2H2 Zn finger	201..222	CDD:275368	10/20 (50%)
		C2H2 Zn finger	237..257	CDD:275368	5/19 (26%)
		C2H2 Zn finger	265..285	CDD:275368	9/19 (47%)
		zf-C2H2_8	268..349	CDD:292531	26/80 (33%)
		C2H2 Zn finger	294..315	CDD:275368	6/20 (30%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
ZNF560	NP_689689.2	KRAB	13..69	CDD:214630
		KRAB	13..50	CDD:279668
		KRAB	110..161	CDD:214630
		KRAB	110..149	CDD:279668
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	323..342	CDD:275368
		COG5048	344..754	CDD:227381	94/327 (29%)
		C2H2 Zn finger	350..370	CDD:275368
		zf-H2C2_2	362..386	CDD:290200
		C2H2 Zn finger	378..398	CDD:275368
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368
		C2H2 Zn finger	490..510	CDD:275368	10/20 (50%)
		zf-H2C2_2	502..527	CDD:290200	13/26 (50%)
		C2H2 Zn finger	518..538	CDD:275368	10/20 (50%)
		zf-H2C2_2	531..554	CDD:290200	11/30 (37%)
		C2H2 Zn finger	546..566	CDD:275368	5/19 (26%)
		zf-H2C2_2	558..582	CDD:290200	10/23 (43%)
		C2H2 Zn finger	574..594	CDD:275368	9/19 (47%)
		zf-H2C2_2	586..610	CDD:290200	7/24 (29%)
		zf-C2H2	600..622	CDD:278523	6/22 (27%)
		C2H2 Zn finger	602..622	CDD:275368	6/20 (30%)
		C2H2 Zn finger	630..650	CDD:275368	7/19 (37%)
		C2H2 Zn finger	658..678	CDD:275368	6/19 (32%)
		C2H2 Zn finger	714..734	CDD:275368	3/19 (16%)
		zf-H2C2_2	726..751	CDD:290200	5/24 (21%)
		C2H2 Zn finger	742..762	CDD:275368	1/19 (5%)
		zf-H2C2_2	757..779	CDD:290200	4/17 (24%)
		C2H2 Zn finger	770..790	CDD:275368	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000