DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ser6 and KLK4

DIOPT Version :9

Sequence 1:NP_523426.1 Gene:Ser6 / 33073 FlyBaseID:FBgn0011834 Length:259 Species:Drosophila melanogaster
Sequence 2:NP_004908.4 Gene:KLK4 / 9622 HGNCID:6365 Length:254 Species:Homo sapiens


Alignment Length:262 Identity:73/262 - (27%)
Similarity:119/262 - (45%) Gaps:42/262 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 FLLFLVLPVQSAPGKLNG---RVVGGEDAVKNQFPHQVSLRNAGSHSCGGSILTRTYILTAAHCV 74
            ||.:|:|.|  |...::|   :::.|||...:..|.|.:|.......|.|.::...::|:||||.
Human    11 FLGYLILGV--AGSLVSGSCSQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCF 73

  Fly    75 SNEDVNHVITPIAAERFTIRAGSN----DRFSGGVLVQVAEVIVHEEYGNFL--NDVALLRLESP 133
            .|.             :||..|.:    |:..|..:|:.:..:.|.||...|  ||:.|::|:..
Human    74 QNS-------------YTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDES 125

  Fly   134 LILSASIQPIDLPTVDTPADVDVVISGWGRIKHQGDLPRYLQYNTLKSITRQQCEELIDFGFEGE 198
            :..|.:|:.|.:.:....|....::||||.:.: |.:|..||...:..::.:.|.:|.|      
Human   126 VSESDTIRSISIASQCPTAGNSCLVSGWGLLAN-GRMPTVLQCVNVSVVSEEVCSKLYD------ 183

  Fly   199 LCLLH---------QVDNGACNGDSGGPAVYNNQLVGVAGFVVDGCGST-YPDGYARVFYFKDWI 253
             .|.|         |....:||||||||.:.|..|.|:..|....||.. .|..|..:..|.:||
Human   184 -PLYHPSMFCAGGGQDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWI 247

  Fly   254 KK 255
            :|
Human   248 EK 249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ser6NP_523426.1 Tryp_SPc 31..253 CDD:214473 63/237 (27%)
Tryp_SPc 32..256 CDD:238113 66/240 (28%)
KLK4NP_004908.4 Tryp_SPc 31..250 CDD:238113 66/240 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D469244at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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