Protein Alignment Ser6 and TMPRSS5

DIOPT Version :10

• Sequence 1: NP_523426.1
• Gene: Ser6 / 33073
• FlyBaseID: FBgn0011834
• Length: 259
• Species: Drosophila melanogaster
• Sequence 2: NP_110397.2
• Gene: TMPRSS5 / 80975
• HGNCID: 14908
• Length: 457
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 86/277 - (31%)
• Similarity: 121/277 - (43%)
• Gaps: 50/277 - (18%)

  Fly     2 TFGKVAILLCSFLLFLVLPVQSAPGKLNGRVVGGEDAVKNQFPHQVSLRNAGSHSCGGSILTRTY 66
            |.|:|..|.||         :.....|..|:|||:.....::|.|.|:.....|:||||:|...:
Human   197 TSGQVVSLRCS---------ECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRW 252

  Fly    67 ILTAAHCVSNEDVNHVITPIAAERFTIRAG----SNDRFSGGVLVQVAEVIVHEEYG--NFLNDV 125
            ::|||||:      |.........:.:.||    |..|...|.||:  .:|.|..|.  |...||
Human   253 VVTAAHCM------HSFRLARLSSWRVHAGLVSHSAVRPHQGALVE--RIIPHPLYSAQNHDYDV 309

  Fly   126 ALLRLESPLILSASIQPIDLPTVDT--PADVDVVISGWGRI----KHQGDLPRYLQYNTLKSITR 184
            |||||::.|..|.::..:.||..:.  |......:||||..    .:..|:   ||...:...:.
Human   310 ALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM---LQDTVVPLFST 371

  Fly   185 QQCEELIDFGFEGE-----LC---LLHQVDNGACNGDSGGPAVYNN----QLVGVAGFVVDGCGS 237
            |.|..  ...:.|.     ||   |..:.|  ||.||||||.|..:    :||||..: ..||..
Human   372 QLCNS--SCVYSGALTPRMLCAGYLDGRAD--ACQGDSGGPLVCPDGDTWRLVGVVSW-GRGCAE 431

  Fly   238 -TYPDGYARVFYFKDWI 253
             .:|..||:|..|.|||
Human   432 PNHPGVYAKVAEFLDWI 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser6	NP_523426.1	Tryp_SPc	32..256	CDD:238113	78/247 (32%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:464747	6/24 (25%)
		Tryp_SPc	217..448	CDD:214473	77/246 (31%)