DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ser6 and PRSS1

DIOPT Version :9

Sequence 1:	NP_523426.1	Gene:	Ser6 / 33073	FlyBaseID:	FBgn0011834	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	255	Identity:	77/255 - (30%)
Similarity:	121/255 - (47%)	Gaps:	34/255 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLFLVLPVQSAPGKLNGRVVGGEDAVKNQFPHQVSLRNAGSHSCGGSILTRTYILTAAHCVSNED 78
            :|..|....:||...:.::|||.:..:|..|:|||| |:|.|.||||::...::::|.||..:
Human   231 ILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSL-NSGYHFCGGSLINEQWVVSAGHCYKS-- 292

  Fly    79 VNHVITPIAAERFTIRAG--------SNDRFSGGVLVQVAEVIVHEEYG--NFLNDVALLRLESP 133
                       |..:|.|        .|::|     :..|::|.|.:|.  ...||:.|::|.|.
Human   293 -----------RIQVRLGEHNIEVLEGNEQF-----INAAKIIRHPQYDRKTLNNDIMLIKLSSR 341

  Fly   134 LILSASIQPIDLPTVDTPADVDVVISGWGRIKHQG-DLPRYLQYNTLKSITRQQCEELIDFGFEG 197
            .:::|.:..|.|||.........:|||||.....| |.|..||......:::.:||.........
Human   342 AVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITS 406

  Fly   198 ELCLLHQVDNG--ACNGDSGGPAVYNNQLVGVAGFVVDGCG-STYPDGYARVFYFKDWIK 254
            .:..:..::.|  :|.||||||.|.|.||.||..: .|||. ...|..|.:|:.:..|||
Human   407 NMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSW-GDGCAQKNKPGVYTKVYNYVKWIK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser6	NP_523426.1	Tryp_SPc	31..253	CDD:214473	70/235 (30%)
Ser6	NP_523426.1	Tryp_SPc	32..256	CDD:238113	73/237 (31%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	70/235 (30%)
		Tryp_SPc	249..467	CDD:238113	73/237 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820