Protein Alignment Ser6 and PLAT

DIOPT Version :10

• Sequence 1: NP_523426.1
• Gene: Ser6 / 33073
• FlyBaseID: FBgn0011834
• Length: 259
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 74/263 - (28%)
• Similarity: 115/263 - (43%)
• Gaps: 54/263 - (20%)

  Fly    31 RVVGGEDAVKNQFPHQVSL-----RNAGSH-SCGGSILTRTYILTAAHCVSNEDVNHVITPIAAE 89
            |:.||..|.....|.|.::     |:.|.. .|||.:::..:||:||||.......|.:|.|...
Human   310 RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGR 374

  Fly    90 RFTIRAGSNDRFSGGVLVQVAEVIVHEEYGN--FLNDVALLRL---------ESPLILSASIQPI 143
            .:.:..|..::     ..:|.:.|||:|:.:  :.||:|||:|         ||.::.:..:.|.
Human   375 TYRVVPGEEEQ-----KFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPA 434

  Fly   144 DLPTVDTPADVDVVISGWGRIKHQGDLPRYLQ-----YNTLKSITRQQCEELI------------ 191
            ||   ..|...:..:||:|  ||:...|.|.:     :..|...:|...:.|:
Human   435 DL---QLPDWTECELSGYG--KHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAG 494

  Fly   192 DFGFEGELCLLHQVDNGACNGDSGGPAVYNNQ----LVGVAGFVVDGCG-STYPDGYARVFYFKD 251
            |....|....||.    ||.||||||.|..|.    |||:..:.: ||| ...|..|.:|..:.|
Human   495 DTRSGGPQANLHD----ACQGDSGGPLVCLNDGRMTLVGIISWGL-GCGQKDVPGVYTKVTNYLD 554

  Fly   252 WIK 254
            ||:
Human   555 WIR 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser6	NP_523426.1	Tryp_SPc	32..256	CDD:238113	73/262 (28%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005
		Tryp_SPc	313..559	CDD:238113	73/260 (28%)