Protein Alignment Ser6 and PRSS53

DIOPT Version :10

• Sequence 1: NP_523426.1
• Gene: Ser6 / 33073
• FlyBaseID: FBgn0011834
• Length: 259
• Species: Drosophila melanogaster
• Sequence 2: XP_011544118.1
• Gene: PRSS53 / 339105
• HGNCID: 34407
• Length: 623
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 70/331 - (21%)
• Similarity: 107/331 - (32%)
• Gaps: 136/331 - (41%)

  Fly     8 ILLCSFLLFLVLPVQSA-----------PGKLNGRVVGGEDAVKNQFPHQVSLRNAGSHSCGGSI 61
            :||.:....|:..:|:|           |....|..|.||      :|.|.|:|..|:|.|.||:
Human     8 VLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGE------WPWQASVRRQGAHICSGSL 66

  Fly    62 LTRTYILTAAHCVSNEDVNHVITPIAAERFTIRAGSNDR---FSGGVLVQVAEVIVHEEYGNFL- 122
            :..|::||||||........:      ..:::..||..|   ..|...|.||.:.:...|.::.
Human    67 VADTWVLTAAHCFEKAAATEL------NSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQ 125

  Fly   123 -NDVALLRLESPLILSASIQPIDL--PTVDTPADVDVVISGWGRIKHQGD--------------- 169
             :|:|||:|..|    .:..|:.|  |....|.......:||.:....|.
Human   126 GSDLALLQLAHP----TTHTPLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGEALCLPS 186

  Fly   170 ---------------LPR---------------YLQYNTLKSITRQQCEELIDFGFEGELCLLHQ 204
                           |||               .|:...|:.|:|..|.           |:.:|
Human   187 VTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCN-----------CIYNQ 240

  Fly   205 VD---------------------NGACNGDSGGPAVYNNQLVGVAGFVVDGCGSTYPDGYARVFY 248
            :.                     .|.|.||||||.:               |  ..|||:
Human   241 LHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVL---------------C--LEPDGH----- 283

  Fly   249 FKDWIK 254
               |::
Human   284 ---WVQ 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser6	NP_523426.1	Tryp_SPc	32..256	CDD:238113	63/296 (21%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	63/297 (21%)
		Tryp_SPc	359..>512	CDD:473915