Protein Alignment Ser6 and F12

DIOPT Version :10

• Sequence 1: NP_523426.1
• Gene: Ser6 / 33073
• FlyBaseID: FBgn0011834
• Length: 259
• Species: Drosophila melanogaster
• Sequence 2: NP_000496.2
• Gene: F12 / 2161
• HGNCID: 3530
• Length: 615
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 76/256 - (29%)
• Similarity: 118/256 - (46%)
• Gaps: 43/256 - (16%)

  Fly    31 RVVGGEDAVKNQFPHQVSLRNAGSHS-CGGSILTRTYILTAAHCVSNEDVNHVITPIAAERFTIR 94
            |||||..|::...|:..:|  ...|| |.||::...::||||||:.:..        |.|..|:.
Human   372 RVVGGLVALRGAHPYIAAL--YWGHSFCAGSLIAPCWVLTAAHCLQDRP--------APEDLTVV 426

  Fly    95 AGSNDRFSGGVLVQ---VAEVIVHEEYG--NFLNDVALLRLE-----SPLILSASIQPIDLPT-V 148
            .|...|.......|   |....:||.:.  ::.:|:|||||:     |..:||..:||:.||: .
Human   427 LGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGA 491

  Fly   149 DTPADVDVV-ISGWGRIKHQ----GDLPRYLQYNTLKSITRQQCEELIDFG---FEGELCL-LHQ 204
            ..|::..:. ::|||   ||    .:...:||...:..::.::|......|   ..|.||. ..:
Human   492 ARPSETTLCQVAGWG---HQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLE 553

  Fly   205 VDNGACNGDSGGPAVYNNQ-------LVGVAGFVVDGCGS-TYPDGYARVFYFKDWIKKHS 257
            ....||.||||||.|..:|       |.|:..: ..|||. ..|..|..|.|:..||::|:
Human   554 GGTDACQGDSGGPLVCEDQAAERRLTLQGIISW-GSGCGDRNKPGVYTDVAYYLAWIREHT 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser6	NP_523426.1	Tryp_SPc	32..256	CDD:238113	74/252 (29%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:394967
		Kringle	217..295	CDD:395005
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..359
		Tryp_SPc	373..612	CDD:238113	74/252 (29%)