Protein Alignment Npc1b and AT1G42470

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001319159.1
• Gene: AT1G42470 / 840851
• AraportID: AT1G42470
• Length: 1260
• Species: Arabidopsis thaliana
• Alignment Length: 1278
• Identity: 410/1278 - (32%)
• Similarity: 658/1278 - (51%)
• Gaps: 166/1278 - (12%)

  Fly    48 PLNSPT---SEAIFAK---RCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPT 106
            |.|.|:   .:.:.:|   .||.:       :|    ::||...|.:|:.|.:.||......||.
plant    37 PFNIPSVKPDDLLSSKIQSLCPTI-------TG----NVCCTETQFDTLRSQVQQAIPFIVGCPA 90

  Fly   107 CTRNMALTVCAMTCAKNHTLFLTAYNDT---NDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQ 168
            |.||.....|.:||:.:.:||:...:.|   |::.||.::|.   :|||..:.:|.||..::...
plant    91 CLRNFLNLFCELTCSPDQSLFINVTSTTKVKNNSTVDGIQYY---ITDDFGAGMYESCKNVKFGS 152

  Fly   169 TGRPAMD-LGCGSYNAKTCNYRRWYEFMGDVSGDYV---PFQINYKWSEDAEEGSNEIYLDLSPL 229
            :...|:| ||.|   ||  |::.|:.|:|..:|..:   |:.|.:..:.....|...  :::|..
plant   153 SNSRALDFLGAG---AK--NFKEWFTFIGQKAGVNLPGSPYGIAFLPTPPVSSGMRP--MNVSIY 210

  Fly   230 KCGESYEDSYACACIDCEESCPLTDAPTGPDE-----LWKIAGL--YGVTFILALIIACALSFFI 287
            .||   ::|..|:|.||..:...:.....|.:     ..||..|  ..|.||||::....:|.|:
plant   211 SCG---DESLGCSCGDCPSAATCSSKAEVPTQKKHSCSIKIGSLEVKCVDFILAILYIVLVSLFL 272

  Fly   288 FWG-------------------AFGKTSAPSVCMP--------------------TLFGEF--FY 311
            ..|                   |.|:.::.:...|                    |:.|..  ||
plant   273 GGGLLHPVRGKKKTSQMGTLSEASGERNSVNQQKPDTIQSQMLQNTPQRNWGQLSTVQGHLANFY 337

  Fly   312 HGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGP 376
            ..:.||   .|:||.:||.|....:..|..|:....:.|.|.:||.|..|:...||.:||.|..|
plant   338 GKYGIW---VARHPTLVLCLSVSVVLLLCVGLIRFKVETRPDKLWVGSGSRAAEEKQFFDTHLAP 399

  Fly   377 FYRTNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQDSIMKLGMADNEG----LDKI 437
            |||..|:.:..|..:  :||.:..:|.     :.| :|.:|::|..:..| .|::.|    |..|
plant   400 FYRIEQLIIATVQTS--SHEKAPEILT-----DDN-IKLLFDIQKKVDGL-RANHSGSMVSLTDI 455

  Fly   438 CYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFEN-SYVDSNNYTINYLNQLEDCLRVPMMEDCF 501
            |..|:   ||.     ||.|||..||:...:.::: ..||...|...:....|.||
plant   456 CMKPL---GED-----CATQSVLQYFKMKPENYDDYGGVDHVKYCFEHFTSTESCL--------- 503

  Fly   502 GTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNY--NDESKLEPNMKWEKLFVDFLR 564
            ..|.||::|..|:||....:..|      |:..::|:...|:  |..:|.|..:.|||.|:...:
plant   504 SAFKGPLDPTTALGGFSGNSFSE------ASAFLVTYPVDNFVDNKGNKTEKAVAWEKAFIQLAK 562

  Fly   565 D-----YKSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRES 624
            |     .::..|.:::.:|.||::.:...|..:|.|:.|||:|||.|:::.||.....:.|...|
plant   563 DELLPMVQAKNLTLSFSSESSIEEELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSFYITS 627

  Fly   625 RIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKF 689
            :::|.:.|:::|:.||:.|:||:..:.:.:|::.:||||||||||||||:.|:||..:|.:..
plant   628 KVLLGLSGVLLVMLSVLGSVGFFSAVGMKSTLIIMEVIPFLVLAVGVDNMCILVHAVKRQEQE-- 690

  Fly   690 KTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVAL 754
            ......|..|:.:|||||...:.:|:..||:|....||||:.|:|:||:|:||||||||||||||
plant   691 LPLERRISNALMEVGPSITLASLAEILAFAVGAFIKMPAVRVFSMFAALAVLLDFLLQITAFVAL 755

  Fly   755 MAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVL 819
            :..|.:|..|.|:|...|:|:....|:.|.|.|   .::.|||....|..::|.|....||:.|:
plant   756 IVFDFRRTEDKRVDCFPCIKTSKSSISAEKGVG---QRKAGLLTRYMKEVHAPVLSHWIVKIVVI 817

  Fly   820 LIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNY-SEPL 883
            ..|..:....:.::..||.||:|::.:|::|::..||..:...|.:|.|:|:||| ..|| ||..
plant   818 AFFFGLAMAGIALSTRIEPGLEQQIVLPQDSYLQGYFNNISTYLRIGPPLYFVLK-NYNYSSESR 881

  Fly   884 QQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLA--ISDCCKYNVTTGGFC 946
            ..|.:|...:||.|||..::...:..||::.:|:||:|||||::.||:  ...||: ..|.|.||
plant   882 HTNQLCSINKCNPNSLLNEIARASLTPELSYIAKPAASWLDDFLVWLSPEAFGCCR-KFTNGTFC 945

  Fly   947 SSNSK----------------SEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGR 995
            ..:.:                .:||..|.|....:..||....|.:.:|:||..||.|:|||.|.
plant   946 PPDDQPPCCPPGQTSCGLSEVCKDCTTCFRHADLSSDRPSTTQFKEKLPWFLNALPSADCAKGGH 1010

  Fly   996 ASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKENNVDAEIF 1060
            .:|:.:|  .:.......:|.|.|..|.|......:|.:.:|..:..|.:::...|     .||:
plant  1011 GAYSSSV--DLQGYANGIIQASSFRTYHTPLNKQVDFVNSMRAAQEFSAKVSRSLK-----MEIY 1068

  Fly  1061 AYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWA 1125
            .|.|||:::||||.||..|:.:|.:::.|:|:|.|:|| ....|:.|:|.::..|:|::||:|..
plant  1069 PYSVFYMFFEQYLDIWKTALINLSIAIAAVFVVCLIIT-CSFWSSAIILLVIAMIIIDLLGVMAV 1132

  Fly  1126 WSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRAEGTAQERARHSLNVTGSSVLSGITLTKFAGI 1190
            :.|.|||:|:|||::.|||.|||..||..:|..:.|....|.:.:|...|:||.|||||||..|:
plant  1133 FHIQLNALSVVNLIMSVGIAVEFCVHITHAFSISTGDRNHRMKEALGGMGASVFSGITLTKLVGV 1197

  Fly  1191 VVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGP 1233
            :|||||.|::|.|:||:|||.:||:|..|||:.|||.||:.||
plant  1198 IVLGFSRSEVFVVYYFKMYLALVLLGFLHGLVFLPVFLSMFGP 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	400/1263 (32%)
AT1G42470	NP_001319159.1	2A060601	19..1239	CDD:273337	408/1275 (32%)