Protein Alignment Npc1b and AT4G38350

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001190953.1
• Gene: AT4G38350 / 829992
• AraportID: AT4G38350
• Length: 1297
• Species: Arabidopsis thaliana
• Alignment Length: 1321
• Identity: 423/1321 - (32%)
• Similarity: 662/1321 - (50%)
• Gaps: 213/1321 - (16%)

  Fly    41 GDTNPARPLNSPTS------EAIFAKR----CPMLYKEYKGESGEDELSLCCDAAQIETMESGLS 95
            |..:..:.||.|.:      :.:|:.:    ||.:       ||    ::||...|.:|:.|.:.
plant    45 GHRSDGKVLNCPYASPSIQPDELFSAKIQSLCPTI-------SG----NVCCTETQFDTLRSQVQ 98

  Fly    96 QADGVFSRCPTCTRNMALTVCAMTCAKNHTLFLTAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNS 160
            ||......||.|.||.....|.::|:.|.:||:...:....:|...|..|||.:||.....:|.|
plant    99 QAVPFLVGCPACLRNFLNLFCELSCSPNQSLFINVTSVAEVSGNLTVDGIDYHITDTFGEGLYES 163

  Fly   161 CIGIQH-TQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVS-----GDYVPFQINYKWSEDAEEGS 219
            |..::. |...|....:|.|   ||  |:|.|:.|:|..:     |.  |:.||:|.|  ..|.|
plant   164 CKEVKFGTMNTRAINFVGGG---AK--NFREWFTFIGQKAPSGFPGS--PYAINFKSS--IPESS 219

  Fly   220 NEIYLDLSPLKCGESYEDSYACACIDC----------------EESCPLTDAPTGPDELWKIAGL 268
            ..:.:::|...||::   |..|:|.||                |:||.:...|.      |:.
plant   220 AMVPMNVSVYSCGDT---SLGCSCGDCPSSPACSSPEPLPPHDEDSCSIRIGPL------KVR-- 273

  Fly   269 YGVTFILALIIACALSFFIFWGAFGK---TSAP-----------------SVCMPTLFG------ 307
             .:...:||:....:|.|..|....:   |:.|                 |.....:.|
plant   274 -CIELSMALVYVLLVSCFFGWAGLNRRRNTTQPLDSSKPLLHPVEEDGINSEMKENILGVKVQRH 337

  Fly   308 -------EFFYHGFRIWGTFCAKHP--------VIVLALCSWAIAGLSFGIRYMTITTDPVELWA 357
                   .:....:|.:|::.|::|        .|||||||        |:....:.|.|.:||.
plant   338 AQLSPVQRYMAKFYRSYGSWIARNPSLVLFMSVAIVLALCS--------GLYNFKVETRPEKLWV 394

  Fly   358 GEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHETSNGVLNFGPAF--EYNFLKEVFELQ 420
            |.||:...||.:||.|..||||..|:.:..|      .:..:|   ..|:.  :.|.|. :|::|
plant   395 GPESKAAEEKKFFDTHLSPFYRIEQLILATV------PDPKSG---RAPSIVTDENILL-LFDIQ 449

  Fly   421 DSIMKL--GMADNE-GLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFEN-SYVDSNNYT 481
            ..:.::  ..:.:| .|..||..|:   ||.     ||.||:..||:.|...|:: ..|:...|.
plant   450 QKVDQIRGNYSGSEVSLPDICLKPL---GED-----CATQSILQYFKMDSGTFDDYGGVEHAEYC 506

  Fly   482 INYLNQLEDCLRVPMMEDCFGTFGGPIEPGIAVGGM-----PKVAVGE-----------DPDYML 530
            ..:....|.||         ..|..|::|...:||.     .:|.|.|           |....|
plant   507 FQHYTSSETCL---------SAFQAPVDPSAVLGGFSGNNYSEVMVSELGCSVPFDCYSDVKRTL 562

  Fly   531 --ATGLVLTF-----LGRNYNDESKLEPNMKWEKLFVDFLRD-----YKSDRLDIAYMAERSIQD 583
              ||..|:|:     :|.:.|:.::.   :.|||.|:...::     .:|..|.:::.:|.||::
plant   563 FQATAFVVTYPVNNVIGDSSNENARA---VAWEKSFIQLAKEELLPMVRSKNLSLSFSSESSIEE 624

  Fly   584 AIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWG 648
            .:...|..:|.|:..||:|||||:::.||.......|...|:::|.:.|:|:||.||:.|:|.:.
plant   625 ELKRESTADVITIAASYLVMFVYISVTLGDAPQFYTFYISSKVLLGLSGVVLVLLSVLGSVGVFS 689

  Fly   649 YLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGS 713
            .|.|.:|::.:||||||||||||||:.|:||..:|  ..:..:..:.|..|:.:|||||...:.|
plant   690 ALGVKSTLIIMEVIPFLVLAVGVDNMCILVHAVKR--QPREVSLEQRISSALVEVGPSITLASLS 752

  Fly   714 EMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGK 778
            |:..||:|....|||.:.|:|:||:||:|||.|||||||||:..|.||..|.|:|...|:
plant   753 EVLAFAVGAFVPMPACRIFSMFAALAIMLDFFLQITAFVALIVFDCKRSADNRIDCFPCI----- 812

  Fly   779 KINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQE 843
            |:.....:.|:..:|.|.||...|..::|.|....||:.|:.:|......|:.::|.:|.||:|:
plant   813 KVPSSSRESVEGGREPGFLERYMKEVHAPVLGLWGVKMVVVAVFFAFALASIAISPRLETGLEQK 877

  Fly   844 MSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNY-SEPLQQNLICGGVECNNNSLSVQLYTQA 907
            :.:|::|::..||..:.:.|.:|.|:|:|:| ..|| ||....|.:|...:||:|||..::...:
plant   878 IVLPRDSYLQDYFDSLSEYLRVGPPLYFVVK-NYNYSSESRHTNQLCSISQCNSNSLLNEISRAS 941

  Fly   908 QYPEITSLARPASSWLDDYIDWLA--ISDCCKYNVTTGGFCSSNSK------SED-------CLP 957
            |..:.:.:|:||:|||||::.||:  ...||: ..|.|.:|..:.:      .||       |..
plant   942 QASDTSYIAKPAASWLDDFLVWLSPEAFGCCR-KFTNGSYCPPDDQPPCCTAEEDICSLDGICKD 1005

  Fly   958 CERGFTENGL---RPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMSTVQDSYF 1019
            |...|..:.|   ||....|.:.:|:||..||.|:|||.|..:|.::|  .:.......:|.|.|
plant  1006 CTTCFRHSDLVQDRPSTAQFREKLPWFLNALPSADCAKGGHGAYTNSV--DLKGYESGVIQASEF 1068

  Fly  1020 MQYSTTSTTSEEFYSQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLG 1084
            ..|.|...|..::.:.||..|..|..|:     |::..:||.|.||||::||||.||..|:.:|.
plant  1069 RTYHTPLNTQGDYVNALRAAREFSSRIS-----NSLKIDIFPYSVFYIFFEQYLNIWTVALTNLA 1128

  Fly  1085 MSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFV 1149
            :::.|||:|..|||....:|..|||.:|: ||::::|||....|.|||:|:|||::.:||.|||.
plant  1129 IAIGAIFIVCWLITSSAWSSAIIVLVLVM-ILVDLMGMMVILGIQLNAVSVVNLIMSIGIAVEFC 1192

  Fly  1150 AHIVRSFKRAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVL 1214
            .||..:|..:.|..:.|||.:|...|:||.|||||||..|::||.|:.|:||.|:||:|||.:|:
plant  1193 VHISHAFLMSSGDREHRAREALETMGASVFSGITLTKLVGVIVLCFARSEIFVVYYFQMYLALVI 1257

  Fly  1215 IGAAHGLILLPVLLSLLGPPQ 1235
            ||..|||:.|||:|||.||||
plant  1258 IGFLHGLVFLPVILSLAGPPQ 1278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	410/1304 (31%)
AT4G38350	NP_001190953.1	2A060601	38..1275	CDD:273337	419/1316 (32%)