Protein Alignment Npc1b and Ptchd3

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001395857.1
• Gene: Ptchd3 / 688333
• RGDID: 1590039
• Length: 905
• Species: Rattus norvegicus
• Alignment Length: 935
• Identity: 211/935 - (22%)
• Similarity: 385/935 - (41%)
• Gaps: 178/935 - (19%)

  Fly   337 AGLSFGIRYMTITTDPVELWAGEESQTRI------EKDYFDQHFGPFYRTNQMFVKAVNQTY-FT 394
            |.|..|:.::     |.|....||..|.|      |:.:...||            :.|.:| |:
  Rat   105 ASLGTGLIFL-----PKEKENLEEQYTPIGSPAKAERRFVQSHF------------STNDSYRFS 152

  Fly   395 HETSNGVLNFG---------PAFEYNFLKEVFELQDSIMKLGMADNEGLDKICYAPVLMAGETPT 450
            ...::...||.         ...|.....||..|..::..|.:....| .:|.|..|
  Rat   153 ASRTSSETNFASILVVSHRDSLLEPEAFAEVSRLDRAVQALKVVQENG-TQILYPEV-------- 208

  Fly   451 VDRCAIQSVYGYFQHDMDRF---ENSYVDSNNYTINYLNQLEDCLRVPMMEDCFGTFGGPIEPGI 512
               ||..|| |....:...|   :||.::.:..|....:..:..:.:.      |.|||.:....
  Rat   209 ---CAKYSV-GCVPPNPLLFSWQQNSSLNLSELTFPIHSVADHLIHLA------GFFGGNVLGYA 263

  Fly   513 AVGGMPKVAVGEDPD--YMLATGLVLTFLGRNYNDESKLEPNMKWEKLFVDFLRDYKSD----RL 571
            ..|...::.......  |.|.|           .|....|.:..|...|:|...|.|||    .:
  Rat   264 TTGNRQRLVESRAMRLLYYLKT-----------EDPEDRERSQAWLTHFLDHFNDMKSDLALEDI 317

  Fly   572 DIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIV 636
            ::.|....|.|......|:..:....::|:::.::..::...:...|     :::.:|:.|:..|
  Rat   318 EVVYFTSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRLDCIR-----NKMWVAVFGVFSV 377

  Fly   637 LASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIG 701
            ..|||...|...::.|...:: :...|||:|.||||::|||:..:|:.  |..::..|.:..:..
  Rat   378 AMSVVSGFGLMLHIGVPFVII-VANSPFLILGVGVDDMFIMISAWQKT--SLTESVSERLSNSYS 439

  Fly   702 QVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEK------ 760
            :|..||..|..:.:..|..|..|...:|:.|.:|....:|..:...||.|.|:||:|.|
  Rat   440 KVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKREVVWS 504

  Fly   761 RYLD------GRLDMLCCVKSGGKKINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVL 819
            |:|:      ......|||..|  ...||.||. :.|     :...|::::.|||.:...|..|:
  Rat   505 RWLEKPDQKYSSFKKFCCVPFG--SFPDEHGDD-NHP-----MNLFFRDYFGPFLTTSKAKFIVV 561

  Fly   820 LIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLA-MGAPVYWVLKPGLNY-SEP 882
            ||:......|:.....:::|||.......:|::..||....|..: .|..|..::...:|| .:.
  Rat   562 LIYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTETVNYWDKD 626

  Fly   883 LQQNLICGGVECNNNSLSVQLYTQAQYPE--ITSLARPASSWLDDYIDWLAISDCCKYNVTTGGF 945
            ::|.|    .:|      :..:.|.:|.:  :|..      ||:.|:         :|...||.
  Rat   627 VRQKL----DKC------MTQFEQNEYVDKNLTEF------WLEAYM---------QYMNNTGN- 665

  Fly   946 CSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVG 1010
             :.|.|             |....:...|..:.|.|.:|:   ..:.:...:.:...|.|||
  Rat   666 -NPNDK-------------NTFMNNIAGFLNFFPVFTYDI---NVSSSNEITSSRGFIQTID--- 710

  Fly  1011 MSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTI 1075
                        .::|:..:....:||.:            ..|.:..:..|...:||::||..|
  Rat   711 ------------VSSSSNKKRMLLKLRGI------------AENCEVPLMVYNQAFIYFDQYAAI 751

  Fly  1076 WGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVV 1140
            ..:.:.::.::..|:|:|:||:....:.|.: |.|.:..:::.:.|.|..|::||::||::|||:
  Rat   752 IENTVRNVMIASTAMFIVSLLLIPHPVCSLW-VTFAIASVIVGVTGFMAFWNVNLDSISMINLVI 815

  Fly  1141 CVGIGVEFVAHIVRSFKRA-EGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVF 1204
            |:|...:|.|||..:|..: |.:..:::..:|.:.|..||.. .::...|:.||..:.:.||:.|
  Rat   816 CIGFSFDFSAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQS-AISTIIGVCVLAAAKAYIFRTF 879

  Fly  1205 YFRMYLGIVLIGAAHGLILLPVLLS 1229
            :..|:| ::..|||||||.:||.|:
  Rat   880 FKIMFL-VMFFGAAHGLIFIPVFLT 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	204/924 (22%)
Ptchd3	NP_001395857.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67
		Patched	125..905	CDD:308203	204/910 (22%)