DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Npc1b and scap

DIOPT Version :9

Sequence 1:	NP_608417.2	Gene:	Npc1b / 33072	FlyBaseID:	FBgn0261675	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_005158307.1	Gene:	scap / 558292	ZFINID:	ZDB-GENE-040107-41	Length:	1294	Species:	Danio rerio

Alignment Length:	756	Identity:	152/756 - (20%)
Similarity:	274/756 - (36%)	Gaps:	230/756 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 TSAPSVCM-----PTLFGEFFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTIT-TDPV 353
            |.||.:.:     ..:...|:.||.     .||.:||.::...|.:|....:.:..:.:. |.||
Zfish    45 TPAPRMTVRERLRQNISAAFYRHGL-----LCASYPVPIILFTSASILTCCYPLLKLPLPGTGPV 104

  Fly   354 ELWAG--------EESQTRIEK--DYFDQHFGPFYRTNQMFVKAVNQTYFTHETSNGVLNFGPAF 408
            |...|        .|||..:.:  |::  ...|.....|:.|||....:     .|.::   |..
Zfish   105 EFTTGVRDYSIPSHESQGDLSERPDWY--RGPPVAYIQQVLVKAAVSPW-----GNSLV---PVD 159

  Fly   409 EYNF-LKEVFELQDSIMKLGMADNEGLDKICYAPVLMAGETPTVDR---------CAIQSVYGYF 463
            .:.. |..||.|.|.|......| ..|:.:|   :.:....|.:.|         |.:.|...|:
Zfish   160 VFRSPLGRVFSLLDEIRNHVYTD-RSLEALC---LQVTDLLPGLRRMQAVLPEHGCLLVSPGNYW 220

  Fly   464 QHDMDRFENSYVDSNNYTINYLNQ-----------LEDCLRVPMMEDCFGTFGGP-IEPGIAVGG 516
            |:..|.|     |::...:..::|           |.|.|           ||.| .:.|:::..
Zfish   221 QNRRDLF-----DADPDLLKTVHQHEPKGLHTSATLRDLL-----------FGVPGKQTGVSLYS 269

  Fly   517 MPKVAVGEDPDYMLATGLVLTFLGRNYNDESKLEPNMKWEKLFVDFLR------------DYKSD 569
            ..:|..     |.:...|                  ..::..||..||            ..:.|
Zfish   270 KKRVVT-----YTVTIAL------------------SSYDARFVGSLRARLKQLHPSANCTLRED 311

  Fly   570 RLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIV 634
            .:...:..|        |:...|:..:|.:|:::|.|:..:...|...|     |:..||:..:|
Zfish   312 HMVHVHFKE--------EIGIAELIPLVTTYIILFAYIYFSTRKIDMVR-----SKWGLALAAVV 363

  Fly   635 IVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIM----VHTYQRLDHSKFKTTHEA 695
            .||:|::.|:|......:|.|:...|:.|:||:.:|::|:.::    |.|...|: .|.:
Zfish   364 TVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLE-VKLR----- 422

  Fly   696 IGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEK 760
            |.:.:.....||::...:|:....||..:.:||::.|.::|.:.::.||.||:..|..:::||.:
Zfish   423 IAQGLSNESWSIMKNMATELCIILIGYFTFVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIR 487

  Fly   761 RYLDGRLDMLCCVKSGGKKINDEDG-----DGVDRPKE-----------VGLLETLFKNFYSP-- 807
            |.....|:         :::..|.|     .|..||:|           :.|....|:|...|
Zfish   488 RMELADLN---------RRLPAEAGMPPPKPGTLRPRETPPPPRPSPHTITLQTPAFRNLRLPKR 543

  Fly   808 -----FLLSKPVKVSVLLIFTVI--------------TCLSLMVTPSIEKGLDQEMSMPKNSHVV 853
                 ||....:...::::.|||              |.|:..|:.....|   |..:|.:..|
Zfish   544 LRVVYFLARTRLAQRIIMVGTVIWIGILVYTDPAGLRTFLAAQVSEQSPLG---EAGLPPHLGV- 604

  Fly   854 KYFRYMVDLLAMGAPVYWVLKPGLNYSE-----------PLQQNLICGGVECNNNSLSVQLYTQA 907
                         |||:    ||.:.:.           ||.:|...|              .:|
Zfish   605 -------------APVF----PGGHPTSTLSVLPAPEPTPLPENQSQG--------------HRA 638

  Fly   908 QYPEITSLARPASSW-LDDYIDWLAISD------CCKYNVT 941
            ..|.:..::.|..:| .:|...|..:|.      ...||:|
Zfish   639 ARPGVAPVSSPQITWGSEDEELWRRLSFRHWPSLFSYYNIT 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	152/756 (20%)
		NPC1_N	24..270	CDD:293023
		nitrilase	<265..>331	CDD:299711	10/40 (25%)
		Sterol-sensing	623..775	CDD:289145	40/155 (26%)
scap	XP_005158307.1	Sterol-sensing	350..490	CDD:289145	40/150 (27%)
		WD40	<796..>836	CDD:295369
		WD40 repeat	977..1022	CDD:293791
		WD40	992..>1250	CDD:225201
		WD40 repeat	1047..1091	CDD:293791
		WD40	1093..>1263	CDD:295369
		WD40 repeat	1098..1132	CDD:293791
		WD40 repeat	1137..1172	CDD:293791
		WD40 repeat	1179..1212	CDD:293791
		WD40 repeat	1219..1253	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910