DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npc1b and npc1

DIOPT Version :9

Sequence 1:	NP_608417.2	Gene:	Npc1b / 33072	FlyBaseID:	FBgn0261675	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_005163715.1	Gene:	npc1 / 553330	ZFINID:	ZDB-GENE-030131-3161	Length:	1277	Species:	Danio rerio

Alignment Length:	1306	Identity:	503/1306 - (38%)
Similarity:	731/1306 - (55%)	Gaps:	140/1306 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KVIFATIWLIAGAWSQSAEQLGCIWYGQ---SHMIGAHWVNKGDTNPARPLNSPTSEAIFAKRCP 63
            :::.||:.|  ..|.....   |||||:   |..:....:|...|.||.||.:...| :..:.||
Zfish    11 RLLLATVLL--SHWVHGQH---CIWYGECGNSPNVPEKKLNCNYTGPAVPLPNEGQE-LLQELCP 69

  Fly    64 -MLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLF 127
             ::|.:.:         :|||..|:.|::|.:.......||||.|..|.....|.:||:...:.|
Zfish    70 RLVYADNR---------VCCDTQQLNTLKSNIQIPLQYLSRCPACFFNFMTLFCELTCSPRQSQF 125

  Fly   128 LTAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWY 192
            ::..:...:.....|..:.|.:|......::|:|..:|...:...|:.|.||. :|..|..:.|.
Zfish   126 ISVKDFLKEKNQTSVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGR-DASVCTPQIWI 189

  Fly   193 EFMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPL-----KCGESYED-SYACACIDCEESCP 251
            ::|..:|...|||.|...:::...:|       ::|:     .|.:|.:| |..|:|.||.|.|.
Zfish   190 QYMFSISNGQVPFGIEPIFTDVPVQG-------MTPMNNRTFNCSQSLDDGSEPCSCQDCSEVCG 247

  Fly   252 LTDAPTGPDELWKIAGLYGVTFIL-ALIIACALSFF-IFWGA-----------FG---KTSAP-- 298
            .|..|......|.|.||..::||: ...||..|.|| :..||           :|   .::.|
Zfish   248 PTPVPPPIPPPWIILGLDAMSFIMWCSYIAFLLIFFGVVLGAWCYRRSVVTSEYGPILDSNQPHS 312

  Fly   299 -----------SVCMPTLFGEFFYHGFRI----WGTFCAKHP-------VIVLALCSWAIAGLSF 341
                       :.|..|: ||.|.:..|:    ||:.|.:.|       ::::.:||   ||||
Zfish   313 LNSDGTDLIDEASCCETV-GERFENSLRLVFSRWGSLCVRQPLTIILSSLVLICICS---AGLS- 372

  Fly   342 GIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHE----TSNG-V 401
               ||.|||:|||||:...|:.|.||:|||||||||:||.|:.:    .|.:|.|    |..| :
Zfish   373 ---YMRITTNPVELWSAPSSRARQEKNYFDQHFGPFFRTEQLII----TTPWTEEGGFSTITGDI 430

  Fly   402 LNFGPAFEYNFLKEVFELQDSIMKLGMADNEG----LDKICYAPVLMAGETPTVDRCAIQSVYGY 462
            :.|.|....:.|.:|.:||..|..| :|:.:|    |..||.:|:     :|..|.|.|.||..|
Zfish   431 IPFSPILNLSLLHQVLDLQLEIENL-IAEYKGENVTLKDICVSPL-----SPYNDNCTILSVLNY 489

  Fly   463 FQHDMDRFENSYVDS----NNYTINYL------NQLEDCLRVPMMEDCFGTFGGPIEPGIAVGGM 517
            ||:..:..::.:.|.    |:|..:.|      ..|:|..|  :.:.|.||||||:.|.:.:||.
Zfish   490 FQNSHEVLDHEFQDEFFLYNDYHTHLLYCASSPTSLDDTSR--LHDPCMGTFGGPVFPWLVLGGY 552

  Fly   518 PKVAVGEDPDYMLATGLVLTFLGRNY-NDESKLEPNMKWEKLFVDFLRDYKSDRLDIAYMAERSI 581
                  ||..|..||.||:||...|| ||..||...:.|||.|:.|:::|::..|.:::.:||||
Zfish   553 ------EDSAYNNATALVITFPVTNYLNDTEKLGKALAWEKEFIRFMKNYENPNLTVSFSSERSI 611

  Fly   582 QDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGF 646
            :|.|...|..:|||:||||::||||:::|||.|.|||..|.:|:|.|.|.||:|||:||.||||.
Zfish   612 EDEIDRESNSDVSTIVISYIIMFVYISVALGRINSCRTLLVDSKISLGIAGILIVLSSVACSLGI 676

  Fly   647 WGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTA 711
            :.|:.:..|::.||||||||||||||||||:|.||||.:....:..|:.||..:|.|.||:..::
Zfish   677 FSYIGIPLTLIVIEVIPFLVLAVGVDNIFIIVQTYQRDERMPEEELHQQIGRILGDVAPSMFLSS 741

  Fly   712 GSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSG 776
            .||...|.:|.:|.||||:||:::|.:||.:||||||:.||:|:.:|.||....|:|:|||||.
Zfish   742 FSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKL- 805

  Fly   777 GKKINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLD 841
                    .||.:...| |.|...||..|:||:|...|:..|:.:|..:...|:.|...:|.||:
Zfish   806 --------SDGQEEKSE-GWLFRFFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLE 861

  Fly   842 QEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQ 906
            |.:|||.:|:|:.||..:...|..|.|||:|::.|.:|.....||.:||||.|||:||..|:||.
Zfish   862 QTLSMPDDSYVLNYFGNLSKYLHTGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQIYTA 926

  Fly   907 AQYPEITSLARPASSWLDDYIDWL-AISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENG-LRP 969
            :.....|.::...|||||||.||: ..|.||:|..:||.||:::...:.|:.| |..|.:| .||
Zfish   927 SLMSNYTRISNVPSSWLDDYFDWVKPQSTCCRYYNSTGAFCNASVVDKSCVHC-RPMTSSGKQRP 990

  Fly   970 DAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTID--DVGMSTVQDSYFMQYSTTSTTSEEF 1032
            :...|..::|.||.|.|:.:|.|.|.|:|..||....:  |||.     :|||.|.|....|.:|
Zfish   991 NGTEFMHFLPMFLSDNPNIKCGKGGHAAYGTAVDLKDNNTDVGA-----TYFMSYHTILKNSSDF 1050

  Fly  1033 YSQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLI 1097
            .:.::..|.::..|......::...::|.|.|||::|||||||..|...:||:||.|||:||.::
Zfish  1051 INAMKMARELTDNITQTLSTHDKSYKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVL 1115

  Fly  1098 TGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRAEGT 1162
            .|.::.|..:|.|.:..|||||.|:||.|||:|||:||||||:..||.|||.:||||:|..:..:
Zfish  1116 LGFELWSAVLVCFTIAMILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRS 1180

  Fly  1163 AQ-ERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPV 1226
            :: |||..:|...||||.||||||||.||::|..|.|||||:|||||||.|||:|||||||.|||
Zfish  1181 SRVERAEEALAHMGSSVFSGITLTKFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPV 1245

  Fly  1227 LLSLLG 1232
            |||..|
Zfish  1246 LLSYAG 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	488/1270 (38%)
		NPC1_N	24..270	CDD:293023	69/255 (27%)
		nitrilase	<265..>331	CDD:299711	24/105 (23%)
		Sterol-sensing	623..775	CDD:289145	79/151 (52%)
npc1	XP_005163715.1	NPC1_N	26..247	CDD:293023	62/241 (26%)
		2A060601	28..1251	CDD:273337	498/1282 (39%)
		Sterol-sensing	651..804	CDD:289145	79/152 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	211	1.000	Domainoid score	I2741
eggNOG	1	0.900	-	-		E1_KOG1933
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55095
OrthoDB	1	1.010	-	-		D31089at33208
OrthoFinder	1	1.000	-	-		FOG0001659
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101370
Panther	1	1.100	-	-	O	PTHR45727
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X943
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.790