Protein Alignment Npc1b and NPC1

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: XP_005258334.1
• Gene: NPC1 / 4864
• HGNCID: 7897
• Length: 1303
• Species: Homo sapiens
• Alignment Length: 1302
• Identity: 493/1302 - (37%)
• Similarity: 711/1302 - (54%)
• Gaps: 133/1302 - (10%)

  Fly    12 AGAWSQSAEQLGCIWYGQSHM-IGAHWVNKGDTNPARPLNSPTSEAIFAKRCPMLYKEYKGESGE 75
            |..:|||     |:|||:..: .|....|...:.|.:||.....:.: .:.||..:        .
Human    18 AQVFSQS-----CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLV-QELCPGFF--------F 68

  Fly    76 DELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFL--TAYND----- 133
            ..:|||||..|::|::..|.......||||:|..|:....|.:||:...:.||  ||..|
Human    69 GNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPV 133

  Fly   134 TNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDV 198
            ||....: ||.:.|.:.....:.:||:|..::...:...|:.|.||. :|..||...|.|:|.:.
Human   134 TNQTKTN-VKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGK-DADACNATNWIEYMFNK 196

  Fly   199 SGDYVPFQINYKWSEDAEEGSNEIYLDLSPLK-----CGESYEDSYA-CACIDCEESCPLTDAPT 257
            .....||.|...:|:....|       :.|:.     |.||.::..| |:|.||...|.....|.
Human   197 DNGQAPFTITPVFSDFPVHG-------MEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPP 254

  Fly   258 GPDELWKIAGL---YGVTFI--LALIIACALSFFIFW----------------------GAFGKT 295
            .|...|.|.||   |.:.:|  :|.::....:||..|                      .|..|.
Human   255 PPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKG 319

  Fly   296 SA-------PSVCMPTLFGE--------FFYHG-----FRIWGTFCAKHPVIVLALCSWAIAGLS 340
            :|       ||  .|.|.||        ..:.|     |..||:||.::|..|:......|...|
Human   320 TAWLLTSTFPS--SPVLPGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACS 382

  Fly   341 FGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKA------VNQTYFTHETSN 399
            .|:.::.:||:||:||:...||.|:||:|||||||||:||.|:.::|      :.|.|    .|.
Human   383 SGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPY----PSG 443

  Fly   400 GVLNFGPAFEYNFLKEVFELQDSIMKLGMA-DNE--GLDKICYAPVLMAGETPTVDRCAIQSVYG 461
            ..:.|||..:...|.:|.:||.:|..:..: |||  .|..||.||:     :|....|.|.||..
Human   444 ADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPL-----SPYNTNCTILSVLN 503

  Fly   462 YFQHDMDRFENSYVDSNNYTINYLNQLEDCLRVP--------MMEDCFGTFGGPIEPGIAVGGMP 518
            |||:.....::...|......:|......|:|.|        :.:.|.||||||:.|.:.:||.
Human   504 YFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGY- 567

  Fly   519 KVAVGEDPDYMLATGLVLTFLGRN-YNDESKLEPNMKWEKLFVDFLRDYKSDRLDIAYMAERSIQ 582
                 :|.:|..||.||:||...| |||..||:....|||.|::|:::||:..|.|::.|||||:
Human   568 -----DDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLTISFTAERSIE 627

  Fly   583 DAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFW 647
            |.:...|:.:|.||||||.:||:|:::||||::|||..|.:|::.|.|.||:|||:||.||||.:
Human   628 DELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVF 692

  Fly   648 GYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAG 712
            .|:.:..|::.||||||||||||||||||:|..|||.:..:.:|..:.:|..:|:|.||:..::.
Human   693 SYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSF 757

  Fly   713 SEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGG 777
            ||...|.:|.:|.||||.||:::|.:|:.:|||||||.||:|:.:|.||....|||:.|||:..
Human   758 SETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGA- 821

  Fly   778 KKINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQ 842
                 |||..|...:  ..|...|||.|||.||...::..|:.||..:...|:.|...::.||||
Human   822 -----EDGTSVQASE--SCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQ 879

  Fly   843 EMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQA 907
            .:|||.:|::|.||:.:...|..|.|||:||:.|.:|:....||::|||:.|||:||..|::..|
Human   880 SLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAA 944

  Fly   908 QYPEITSLARPASSWLDDYIDWL-AISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDA 971
            |....|.:....|||:|||.||: ..|.||:.:..|..||:::.....|:.|.....|...||..
Human   945 QLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQG 1009

  Fly   972 ETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMST-VQDSYFMQYSTTSTTSEEFYSQ 1035
            ..|.:::|.||.|.|:.:|.|.|.|:|:.||...:   |..| |..:|||.|.|...||.:|...
Human  1010 GDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILL---GHGTRVGATYFMTYHTVLQTSADFIDA 1071

  Fly  1036 LREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGL 1100
            |::.|.|:..:......|.....:|.|.|||::|||||||..|.:|:||:||.||||||:::.|.
Human  1072 LKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGC 1136

  Fly  1101 DITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFK-RAEGTAQ 1164
            ::.|..|:...:..:|:||.|:||.|.|:|||:||||||:..||.|||.:||.|:|. ..:|:..
Human  1137 ELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRV 1201

  Fly  1165 ERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLS 1229
            |||..:|...||||.||||||||.|||||.|:.|||||:|||||||.:||:||.||||.||||||
Human  1202 ERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1266

  Fly  1230 LL 1231
            .:
Human  1267 YI 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	479/1277 (38%)
NPC1	XP_005258334.1	2A060601	25..1268	CDD:273337	489/1288 (38%)