DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1b and NPC1

DIOPT Version :9

Sequence 1:NP_608417.2 Gene:Npc1b / 33072 FlyBaseID:FBgn0261675 Length:1254 Species:Drosophila melanogaster
Sequence 2:XP_005258334.1 Gene:NPC1 / 4864 HGNCID:7897 Length:1303 Species:Homo sapiens


Alignment Length:1302 Identity:493/1302 - (37%)
Similarity:711/1302 - (54%) Gaps:133/1302 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 AGAWSQSAEQLGCIWYGQSHM-IGAHWVNKGDTNPARPLNSPTSEAIFAKRCPMLYKEYKGESGE 75
            |..:|||     |:|||:..: .|....|...:.|.:||.....:.: .:.||..:        .
Human    18 AQVFSQS-----CVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLV-QELCPGFF--------F 68

  Fly    76 DELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFL--TAYND----- 133
            ..:|||||..|::|::..|.......||||:|..|:....|.:||:...:.||  ||..|     
Human    69 GNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATEDYVDPV 133

  Fly   134 TNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDV 198
            ||....: ||.:.|.:.....:.:||:|..::...:...|:.|.||. :|..||...|.|:|.:.
Human   134 TNQTKTN-VKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGK-DADACNATNWIEYMFNK 196

  Fly   199 SGDYVPFQINYKWSEDAEEGSNEIYLDLSPLK-----CGESYEDSYA-CACIDCEESCPLTDAPT 257
            .....||.|...:|:....|       :.|:.     |.||.::..| |:|.||...|.....|.
Human   197 DNGQAPFTITPVFSDFPVHG-------MEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQPP 254

  Fly   258 GPDELWKIAGL---YGVTFI--LALIIACALSFFIFW----------------------GAFGKT 295
            .|...|.|.||   |.:.:|  :|.::....:||..|                      .|..|.
Human   255 PPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKG 319

  Fly   296 SA-------PSVCMPTLFGE--------FFYHG-----FRIWGTFCAKHPVIVLALCSWAIAGLS 340
            :|       ||  .|.|.||        ..:.|     |..||:||.::|..|:......|...|
Human   320 TAWLLTSTFPS--SPVLPGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITACS 382

  Fly   341 FGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKA------VNQTYFTHETSN 399
            .|:.::.:||:||:||:...||.|:||:|||||||||:||.|:.::|      :.|.|    .|.
Human   383 SGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPY----PSG 443

  Fly   400 GVLNFGPAFEYNFLKEVFELQDSIMKLGMA-DNE--GLDKICYAPVLMAGETPTVDRCAIQSVYG 461
            ..:.|||..:...|.:|.:||.:|..:..: |||  .|..||.||:     :|....|.|.||..
Human   444 ADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPL-----SPYNTNCTILSVLN 503

  Fly   462 YFQHDMDRFENSYVDSNNYTINYLNQLEDCLRVP--------MMEDCFGTFGGPIEPGIAVGGMP 518
            |||:.....::...|......:|......|:|.|        :.:.|.||||||:.|.:.:||. 
Human   504 YFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGY- 567

  Fly   519 KVAVGEDPDYMLATGLVLTFLGRN-YNDESKLEPNMKWEKLFVDFLRDYKSDRLDIAYMAERSIQ 582
                 :|.:|..||.||:||...| |||..||:....|||.|::|:::||:..|.|::.|||||:
Human   568 -----DDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLTISFTAERSIE 627

  Fly   583 DAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFW 647
            |.:...|:.:|.||||||.:||:|:::||||::|||..|.:|::.|.|.||:|||:||.||||.:
Human   628 DELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVF 692

  Fly   648 GYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAG 712
            .|:.:..|::.||||||||||||||||||:|..|||.:..:.:|..:.:|..:|:|.||:..::.
Human   693 SYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSF 757

  Fly   713 SEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGG 777
            ||...|.:|.:|.||||.||:::|.:|:.:|||||||.||:|:.:|.||....|||:.|||:.. 
Human   758 SETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGA- 821

  Fly   778 KKINDEDGDGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQ 842
                 |||..|...:  ..|...|||.|||.||...::..|:.||..:...|:.|...::.||||
Human   822 -----EDGTSVQASE--SCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQ 879

  Fly   843 EMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQA 907
            .:|||.:|::|.||:.:...|..|.|||:||:.|.:|:....||::|||:.|||:||..|::..|
Human   880 SLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAA 944

  Fly   908 QYPEITSLARPASSWLDDYIDWL-AISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDA 971
            |....|.:....|||:|||.||: ..|.||:.:..|..||:::.....|:.|.....|...||..
Human   945 QLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQG 1009

  Fly   972 ETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMST-VQDSYFMQYSTTSTTSEEFYSQ 1035
            ..|.:::|.||.|.|:.:|.|.|.|:|:.||...:   |..| |..:|||.|.|...||.:|...
Human  1010 GDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILL---GHGTRVGATYFMTYHTVLQTSADFIDA 1071

  Fly  1036 LREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGL 1100
            |::.|.|:..:......|.....:|.|.|||::|||||||..|.:|:||:||.||||||:::.|.
Human  1072 LKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGC 1136

  Fly  1101 DITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFK-RAEGTAQ 1164
            ::.|..|:...:..:|:||.|:||.|.|:|||:||||||:..||.|||.:||.|:|. ..:|:..
Human  1137 ELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRV 1201

  Fly  1165 ERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLS 1229
            |||..:|...||||.||||||||.|||||.|:.|||||:|||||||.:||:||.||||.||||||
Human  1202 ERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLS 1266

  Fly  1230 LL 1231
            .:
Human  1267 YI 1268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1bNP_608417.2 2A060601 24..1220 CDD:273337 479/1277 (38%)
NPC1_N 24..270 CDD:293023 72/262 (27%)
nitrilase <265..>331 CDD:299711 26/112 (23%)
Sterol-sensing 623..775 CDD:289145 76/151 (50%)
NPC1XP_005258334.1 NPC1_N 23..267 CDD:293023 74/266 (28%)
2A060601 25..1268 CDD:273337 489/1288 (38%)
Sterol-sensing 666..819 CDD:289145 76/152 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1933
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1850
OMA 1 1.010 - - QHG55095
OrthoDB 1 1.010 - - D31089at33208
OrthoFinder 1 1.000 - - FOG0001659
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101370
Panther 1 1.100 - - O PTHR45727
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X943
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.740

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