Protein Alignment Npc1b and Npc1l1

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001002025.1
• Gene: Npc1l1 / 432367
• RGDID: 1303135
• Length: 1331
• Species: Rattus norvegicus
• Alignment Length: 1287
• Identity: 440/1287 - (34%)
• Similarity: 679/1287 - (52%)
• Gaps: 139/1287 - (10%)

  Fly    45 PARPLNSPTSE--AIFAKRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTC 107
            |||.:   |.|  |:..:.||.||      :|.:....||...|:.::||.:|....:.:|||.|
  Rat    61 PARHV---TGEHLALLQRICPRLY------NGPNTTFACCSTKQLLSLESSMSITKALLTRCPAC 116

  Fly   108 TRNMALTVCAMTCAKNHTLFLTAYNDTN---------DAGVDYVKYIDYRLTDDTVSKIYNSCIG 163
            :.|.....|..||:.:.:||:   |.|.         .|.|.|..:......:    |.|.||..
  Rat   117 SDNFVSLHCHNTCSPDQSLFI---NVTRVVERGAGEPPAVVAYEAFYQRSFAE----KAYESCSQ 174

  Fly   164 IQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVSGDYVPFQINYKWSEDAE---EGSNEIYLD 225
            ::.......|:...||.|.:..||.:||..|.||......|..|.:...|..:   :|...:...
  Rat   175 VRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGK 239

  Fly   226 LSPLKCGESY-EDSYACACIDCEESCPLTDAPTGPDELWKIAGLYGVTFILALIIACALSFFIFW 289
            ::|  |.||. :||..|:|.||..|||:...|......:.:..:.|   .|||||.....|.:..
  Rat   240 IAP--CNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPG---WLALIIIFTAVFVLLS 299

  Fly   290 G---------------AFGKTSAPSVCMP--------TLFGEFFYHGFRIWGTFCAKHPVIVLAL 331
            .               |.|...||.  :|        |:.|.||.:    |||..|..|:.||||
  Rat   300 AVLVRLRVVSNRNKNKAEGPQEAPK--LPHKHKLSPHTILGRFFQN----WGTRVASWPLTVLAL 358

  Fly   332 CSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHE 396
            ....:..|:.|:.::.:||||||||:..:||.|.||.:.|:|||||:||||:||.|.|::.:.::
  Rat   359 SFIVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSSYKYD 423

  Fly   397 T-SNGVLNFGPAFEYNFLKEVFELQDSIMKLGM-----ADNEGLDKICYAPVLMAGETP---TVD 452
            : ..|..||......:||.|:.|||:.:..|.:     ..|..|..|||||:     .|   ::.
  Rat   424 SLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPL-----NPYNTSLS 483

  Fly   453 RCAIQSVYGYFQHDMDRFENSYVDSNNYTINYLNQLED-------CLRVPM-MED-------CFG 502
            .|.:.|:..|||::    ....:.:.|.|:|....|.|       |...|: .:|       |..
  Rat   484 DCCVNSLLQYFQNN----RTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLALSCMA 544

  Fly   503 TFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNY-NDESKLEPNMKWEKLFVDFLRDY 566
            .:|.|:.|.:||||.      :..||..|..|::||...|| .|:.::.....||:.|:..:..:
  Rat   545 DYGAPVFPFLAVGGY------QGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKEMESF 603

  Fly   567 K---SDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIML 628
            :   ||:..:|:.||||::|.|...:..::....:||:::|:|:::|||....|.....||:..|
  Rat   604 QRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSRVAVESKATL 668

  Fly   629 AIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTH 693
            .:||:::||.:|:.::||:.||.|.::::.|:|:||||||||.|||||.|..||||.....:...
  Rat   669 GLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQRE 733

  Fly   694 EAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAID 758
            ..||..:|.|.||:|..:.||..||.:|.::.||||:|||:.:.:||:||||||:||||||:::|
  Rat   734 AHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAIILDFLLQMTAFVALLSLD 798

  Fly   759 EKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKE-VGLLETLFKNFYSPFLLSKPVKVSVLLIF 822
            .||....|.|:|||..:  :|:        ..||| .|||...|:..|:||||.:.::..|:|:|
  Rat   799 SKRQEASRPDVLCCFST--RKL--------PPPKEKEGLLLRFFRKIYAPFLLHRFIRPVVMLLF 853

  Fly   823 TVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNL 887
            ..:...:|.:..:|..|||||:::||:|:::.||.::...|.:|.|||:|...|.|:|.....|.
  Rat   854 LTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEAGMNA 918

  Fly   888 ICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLA-ISDCCKYNVT---TGGFCSS 948
            .|....|.:.||:.::...:::|:.:.:|..||||:||:||||. .|.||:..:.   ...||.|
  Rat   919 TCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSSSCCRLYIRGPHKDEFCPS 983

  Fly   949 NSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMST 1013
            ...|.:||......|...:||.||.|:||:|:||.|.|:..|.|.|.|:|..:|..:.|    ..
  Rat   984 TDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLSSD----GQ 1044

  Fly  1014 VQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKE---NNVDAEIFAYCVFYIYYEQYLTI 1075
            |..|.||.|......|::|...||..|.::..|.|..::   .:.:.|:|.|.:..::|:||||:
  Rat  1045 VIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISNVFYQQYLTV 1109

  Fly  1076 WGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVV 1140
            ..:.:|:|.:..|..|:|..|:.|||:.|..:.|..:|.||::.:|:|..|.|:.||:||:|||.
  Rat  1110 LPEGIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVT 1174

  Fly  1141 CVGIGVEFVAHIVRSFK-RAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVF 1204
            .||:.||||:||.|||. ..:.|..|||:.:....||:|.:|:.:|.|.||::|||:.:|:.|:|
  Rat  1175 AVGMSVEFVSHITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQAQLIQIF 1239

  Fly  1205 YFRMYLGIVLIGAAHGLILLPVLLSLLGP--------PQKLARSSGAEPTAS 1248
            :||:.|.|.|:|..|||:.|||:||.|||        .:|||..:...|..|
  Rat  1240 FFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLASEAAVAPEPS 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	424/1249 (34%)
Npc1l1	NP_001002025.1	2A060601	32..1267	CDD:273337	432/1261 (34%)