DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npc1b and Ptr

DIOPT Version :9

Sequence 1:	NP_608417.2	Gene:	Npc1b / 33072	FlyBaseID:	FBgn0261675	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_001246145.1	Gene:	Ptr / 35546	FlyBaseID:	FBgn0262867	Length:	1169	Species:	Drosophila melanogaster

Alignment Length:	1005	Identity:	237/1005 - (23%)
Similarity:	419/1005 - (41%)	Gaps:	225/1005 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 CMPTLFGEFFYHGFRIWGTFCAKH-------PVIVLALCSWAIAGLSFGIRYMTITTDPVELWAG 358
            |:.....:.|||    .|...|||       ||::..||......|.:.|       ||..|::.
  Fly     7 CVDKTLNKSFYH----LGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQI-------DPEYLFSP 60

  Fly   359 EESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHETSNGVL----NFGPAF-------EYNF 412
            ...:.:.|:...:|:|            .||   :||..:.|.:    .||...       |...
  Fly    61 IAGEGKTERAIVEQYF------------KVN---YTHRFNVGRITRPGRFGRVIVITKDGDENMI 110

  Fly   413 LKEVFELQDSIMKLGMADNEGLDKICYAPVLMAGETPTV-DRCAIQSVYGYFQHDMDRFENSYVD 476
            .:|||:      :|...||    .|..|.....|:|.|. |.||             |:||...:
  Fly   111 RREVFQ------ELRQLDN----IIQNATTTYDGDTYTYKDNCA-------------RWENECFE 152

  Fly   477 SNNYTINYLNQLEDCLRVPMMEDCFGTFGGPIE------PGIAVGGMPKVAVGEDPDYML---AT 532
            ::   |..|:.|.|.:....:...|.....|:.      | :..||   ..:.|| :|::   |.
  Fly   153 ND---ILNLDALMDDIEAGQLNLTFPFMFNPVTWDAHLFP-VFFGG---TKLTED-NYVISVPAI 209

  Fly   533 GLVLTFLGRNYNDESKLEPNMKWEKLFVDFLRDYKSD----RLDIAYMAERSIQDAIVELSEGEV 593
            .||..........::|   ..:||:.|:..:.:.::.    .:.::|.|.|::...:    |...
  Fly   210 QLVYFVTADTKRQDAK---GAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHEL----EKNT 267

  Fly   594 STVVISYVVMFVYVAIALGHIRSC-RGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTML 657
            .|||..:...|  :.:.|..|.:| .|....|:..|.:.|.|..:.:.:.:.|...|..:  ..:
  Fly   268 KTVVPYFSSTF--LLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGI--EFI 328

  Fly   658 AIEV-IPFLVLAVGVDNIFIMVHTYQRLDHSKFK-TTHEAIGEAIGQVGPSILQTAGSEMACFAI 720
            .|.: .|||::.:|:|:.|:|:..::|   :|.| ...|.:|..:.:...||..|:.::...|.|
  Fly   329 GINLAAPFLMIGIGIDDTFVMLAGWRR---TKAKMPVAERMGLMMSEAAVSITITSVTDFISFLI 390

  Fly   721 GCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAID---EKRYL----------------DGR 766
            |.||...:|:.|..|:..|:...||..||.|.|.|||.   |::.|                :.|
  Fly   391 GIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKR 455

  Fly   767 LDMLCCVKSGGKKINDEDG--DGVDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFT---VIT 826
            ..:...:.:||...||.|.  |..|.     :|...||:..:..:.:|..|..::|.|.   |..
  Fly   456 NFLYKAIMAGGIDANDPDNPIDNKDH-----MLMAFFKDKMAAVINNKWCKAIIILAFASYLVGA 515

  Fly   827 CLSLMVTPSIEKGLDQEMSMPKNSHVVKY----------FRYMVDLLAMGAPVYWVLKPGLNYSE 881
            |..:   ..|::||::.....::|:.|::          |.|.:.::..|.         ||||:
  Fly   516 CYGI---TQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGP---------LNYSD 568

  Fly   882 PLQQNLICGGVECNNNSLSVQLY-TQAQYPEITSLARPASSWLDDYIDWLAISDCCKYNVTTGGF 945
            ||.|.    .||...::|....| |..:|.|         |||..::.:|
  Fly   569 PLVQE----QVENLTSTLEHTSYVTSRRYTE---------SWLRSFLSFL--------------- 605

  Fly   946 CSSNSKSEDCLPCERGFTENGLRPDAETFNKYI-PYFLFDLPDAECAKAGRASYADAVIYTIDDV 1009
                .::.:.|        |....|.:||...: .::||         .|.....| |.:..|:.
  Fly   606 ----ERNNELL--------NVTVDDEQTFIDAVKEHWLF---------PGNPFSLD-VRFNEDET 648

  Fly  1010 GMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLT 1074
              ..:...:.:|....:.|:.| ...:|::|:|.       |::.::|.||.  .::::::|:..
  Fly   649 --QIIASRFLIQAVNITDTNHE-KEMVRDLRQIC-------KDSPLNASIFH--PYFVFFDQFEL 701

  Fly  1075 IWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLV 1139
            :...::.::.:..:.:.:::.:... :|..:..|.|.||.|.:.:.|.|..|.:||::||::||:
  Fly   702 VRPVSLQAMVIGAIIMMIISFVFIP-NILCSLWVAFSVISIELGVAGYMALWDVNLDSISMINLI 765

  Fly  1140 VCVGIGVEFVAHIVRSFKRA-EGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQV 1203
            :|:|..|:|.|||..::..: :.:.:.|.|.:|:..|..::.|.:.| ..|||.|..:.|.||.|
  Fly   766 MCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSST-ILGIVALLLAQSYIFLV 829

  Fly  1204 FYFRMYLGIVLIGAAHGLILLPVLLSLLGP 1233
            | |:|...::..||.|||.||||||||.||
  Fly   830 F-FKMVFLVIFFGAMHGLFLLPVLLSLFGP 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	224/990 (23%)
		NPC1_N	24..270	CDD:293023
		nitrilase	<265..>331	CDD:299711	10/36 (28%)
		Sterol-sensing	623..775	CDD:289145	43/172 (25%)
Ptr	NP_001246145.1	Patched	53..845	CDD:280598	210/933 (23%)
Ptr	NP_001246145.1	Sterol-sensing	295..442	CDD:289145	42/151 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910